The inclusion complex of 4-hydroxynonenal with a polymeric derivative of β-cyclodextrin enhances the antitumoral efficacy of the aldehyde in several tumor cell lines and in a three-dimensional human melanoma model

2013 ◽  
Vol 65 ◽  
pp. 765-777 ◽  
Author(s):  
Stefania Pizzimenti ◽  
Eric Ciamporcero ◽  
Piergiorgio Pettazzoni ◽  
Simona Osella-Abate ◽  
Mauro Novelli ◽  
...  
Keyword(s):  
Inclusion Complex ◽  
Tumor Cell ◽  
Cell Lines ◽  
Three Dimensional ◽  
Human Melanoma ◽  
Tumor Cell Lines ◽  
Polymeric Derivative ◽  
Melanoma Model

Locomotory phenotypes of human tumor cell lines and T lymphocytes in a three-dimensional collagen lattice

1997 ◽  
Vol 118 (2) ◽  
pp. 173-180 ◽  
Author(s):  
Bernd Niggemann ◽  
Kerstin Maaser ◽  
Hongqi Lü ◽  
Ronald Kroczek ◽  
Kurt S. Zänker ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Tumor Cell ◽  
Cell Lines ◽  
Three Dimensional ◽  
Human Tumor ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines ◽  
Collagen Lattice

scholarly journals Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: Implications for stress-related enhancement of tumor progression

2009 ◽  
Vol 23 (2) ◽  
pp. 267-275 ◽  
Author(s):  
Eric V. Yang ◽  
Seung-jae Kim ◽  
Elise L. Donovan ◽  
Min Chen ◽  
Amy C. Gross ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Tumor Progression ◽  
Cell Lines ◽  
Human Melanoma ◽  
Tumor Cell Lines ◽  
Melanoma Tumor

scholarly journals Potent Cytotoxic Analogs of Amphidinolides from the Atlantic Octocoral Stragulum bicolor

Marine Drugs ◽  
2019 ◽  
Vol 17 (1) ◽  
pp. 58 ◽  
Author(s):  
Genoveffa Nuzzo ◽  
Bruno Gomes ◽  
Carmela Gallo ◽  
Pietro Amodeo ◽  
Clementina Sansone ◽  
...  
Keyword(s):  
Biological Activity ◽  
Tumor Cell ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Computational Methods ◽  
Melanoma Cell ◽  
Human Melanoma ◽  
Carbon Skeleton ◽  
Human Melanoma Cell ◽  
Tumor Cell Lines

Amphidinolides are cytotoxic macrolides produced by symbiotic unicellular microalgae of the genus Amphidinium. Here we describe the identification of four related molecules belonging to this macrolide family isolated from the invertebrate Stragulum bicolor. The new molecules, named amphidinolide PX1-PX3 and stragulin A (1–4), show an unprecedented carbon skeleton whose complete stereochemistry has been determined by spectroscopic and computational methods. Differences in the structures of these molecules modulate their biological activity in a panel of tumor cell lines, but the opened derivative stragulin (4) shows a very potent and specific cytotoxic activity (IC50 0.18 µM) against the aggressive human melanoma cell A2058.

Interaction of Human Tumor Cells with Human Platelets and the Coagulation System

1983 ◽  
Vol 50 (03) ◽  
pp. 726-730 ◽  
Author(s):  
Hamid Al-Mondhiry ◽  
Virginia McGarvey ◽  
Kim Leitzel
Keyword(s):  
Tumor Cell ◽  
Tumor Cells ◽  
Cell Lines ◽  
Human Tumor ◽  
Human Platelets ◽  
Factor Vii ◽  
Coagulation System ◽  
Breast Adenocarcinoma ◽  
Activate Factor ◽  
Tumor Cell Lines

SummaryThis paper reports studies on the interaction between human platelets, the plasma coagulation system, and two human tumor cell lines grown in tissue culture: Melanoma and breast adenocarcinoma. The interaction was monitored through the use of 125I- labelled fibrinogen, which measures both thrombin activity generated by cell-plasma interaction and fibrin/fibrinogen binding to platelets and tumor cells. Each tumor cell line activates both the platelets and the coagulation system simultaneously resulting in the generation of thrombin or thrombin-like activity. The melanoma cells activate the coagulation system through “the extrinsic pathway” with a tissue factor-like effect on factor VII, but the breast tumor seems to activate factor X directly. Both tumor cell lines activate platelets to “make available” a platelet- derived procoagulant material necessary for the conversion of prothrombin to thrombin. The tumor-derived procoagulant activity and the platelet aggregating potential of cells do not seem to be inter-related, and they are not specific to malignant cells.

Sign in / Sign up

Export Citation Format

Share Document