A fish oil diet induces mitochondrial uncoupling and mitochondrial unfolded protein response in epididymal white adipose tissue of mice

2017 ◽  
Vol 108 ◽  
pp. 704-714 ◽  
Author(s):  
Shylesh Bhaskaran ◽  
Archana Unnikrishnan ◽  
Rojina Ranjit ◽  
Rizwan Qaisar ◽  
Gavin Pharaoh ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Fish Oil ◽  
Unfolded Protein Response ◽  
White Adipose Tissue ◽  
Mitochondrial Uncoupling ◽  
Unfolded Protein ◽  
Epididymal White Adipose Tissue ◽  
Protein Response ◽  
Fish Oil Diet ◽  
Mitochondrial Unfolded Protein Response

scholarly journals Mitochondrial Unfolded Protein Responses in White Adipose Tissue: Lipoatrophy, Whole-Body Metabolism and Lifespan

2021 ◽  
Vol 22 (6) ◽  
pp. 2854
Author(s):  
Masaki Kobayashi ◽  
Yuichiro Nezu ◽  
Ryoma Tagawa ◽  
Yoshikazu Higami
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Whole Body ◽  
Unfolded Protein ◽  
Diet Induced Obesity ◽  
Expression Of Genes ◽  
Whole Body Metabolism ◽  
Living Organisms ◽  
Protein Response ◽  
Mitochondrial Unfolded Protein Response

The mitochondrial unfolded protein response (UPRmt) is a stress response mediated by the expression of genes such as chaperones, proteases, and mitokines to maintain mitochondrial proteostasis. Certain genetically modified mice, which defect mitochondrial proteins specifically in adipocytes, developed atrophy of the white adipose tissue, resisted diet-induced obesity, and had altered whole-body metabolism. UPRmt, which has beneficial functions for living organisms, is termed “mitohormesis”, but its specific characteristics and detailed regulatory mechanism have not been elucidated to date. In this review, we discuss the function of UPRmt in adipose atrophy (lipoatrophy), whole-body metabolism, and lifespan based on the concept of mitohormesis.

scholarly journals At the heart of mitochondrial quality control: many roads to the top

2021 ◽  
Author(s):  
Roberta A. Gottlieb ◽  
Honit Piplani ◽  
Jon Sin ◽  
Savannah Sawaged ◽  
Syed M. Hamid ◽  
...  
Keyword(s):  
Quality Control ◽  
Unfolded Protein Response ◽  
Mitochondrial Biogenesis ◽  
Mitochondrial Dynamics ◽  
Mitochondrial Quality Control ◽  
Unfolded Protein ◽  
Selective Elimination ◽  
Protein Response ◽  
Mitochondrial Unfolded Protein Response

AbstractMitochondrial quality control depends upon selective elimination of damaged mitochondria, replacement by mitochondrial biogenesis, redistribution of mitochondrial components across the network by fusion, and segregation of damaged mitochondria by fission prior to mitophagy. In this review, we focus on mitochondrial dynamics (fusion/fission), mitophagy, and other mechanisms supporting mitochondrial quality control including maintenance of mtDNA and the mitochondrial unfolded protein response, particularly in the context of the heart.

scholarly journals The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling

Cell ◽  
2018 ◽  
Vol 174 (4) ◽  
pp. 870-883.e17 ◽  
Author(s):  
Qian Zhang ◽  
Xueying Wu ◽  
Peng Chen ◽  
Limeng Liu ◽  
Nan Xin ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Unfolded Protein Response ◽  
Unfolded Protein ◽  
Protein Response ◽  
Mitochondrial Unfolded Protein Response
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