Effects of fusarochromanone on mitochondrial function in squamous cell carcinoma and salivary gland carcinoma

Abstract Objective Human papillomavirus (HPV) gained momentum as a potential etiological factor for many types of cancers. Therefore, the aim of this study was to assess the prevalence of HPV-16 infection among Sudanese patients diagnosed with Squamous Cell Carcinoma (SCC) and Salivary Gland Carcinoma. A descriptive, hospital-based study was conducted. 150 formalin-fixed paraffin-embedded blocks were collected. Results The study population included a total of 150 patients aged between 18 to 87 years with a mean age of 48.8 ± 11.9 years. Based on gender, females constituted 46.7% while males constituted 53.3%. The 150 patients were classified into 40 (26.0%) esophageal, 30 (20.0%) nasopharyngeal, 18 (12.0%) conjunctival, 18 (12.0%) tongue 12 (8.0%) laryngeal, 8 (5.3%) lip, 6 (4.0%) oropharyngeal, 6 (4.0%) mucoepidermoid, and 6 (4.0%) adenoid cystic, and 6 (4.0%) myoepithelial carcinomas. Odds ratio for male and female diagnosed with carcinoma was 1.025 [0.439–2.394, 95% CI]. Molecular detection of HPV-16 revealed a prevalence of 26 (17.3%) patients were positive for HPV-16. According to cancer diagnosis, esophageal SCC patients showed a high proportion of HPV-16; 14/40 (35.0%). A statistically significant difference was seen for the distribution of HPV-16 positive patients based on cancer diagnosis, P value 0.001.

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Extramammary Paget’s Disease of the Floor of Mouth Associated With Minor Salivary Gland Carcinoma and Concurrent Invasive Squamous Cell Carcinoma

Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology ◽

10.1016/j.tripleo.2006.12.063 ◽

2007 ◽

Vol 103 (4) ◽

pp. e26 ◽

Cited By ~ 1

Author(s):

M.J. Bullock ◽

C.G. Robertson

Keyword(s):

Squamous Cell Carcinoma ◽

Salivary Gland ◽

Cell Carcinoma ◽

Squamous Cell ◽

Minor Salivary Gland ◽

Paget’S Disease ◽

Invasive Squamous Cell Carcinoma ◽

Salivary Gland Carcinoma ◽

Floor Of Mouth ◽

Gland Carcinoma

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Minor salivary gland carcinomas of oral cavity and oropharynx

The Journal of Laryngology & Otology ◽

10.1017/s002221510900509x ◽

2009 ◽

Vol 123 (S31) ◽

pp. 52-57 ◽

Cited By ~ 6

Author(s):

H Chijiwa ◽

K Sakamoto ◽

H Umeno ◽

T Nakashima ◽

G Suzuki ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Salivary Gland ◽

Oral Cavity ◽

Cell Carcinoma ◽

Minor Salivary Gland ◽

Survival Rates ◽

Salivary Gland Carcinoma ◽

Patients With Cancer ◽

Significant Difference ◽

Gland Carcinoma

AbstractThis paper reviews 22 cases of minor salivary gland carcinoma of the oral cavity or oropharynx which were treated at Kurume University Hospital between 1976 and 2005. Minor salivary gland carcinoma was observed in eight of 362 patients with cancer of the oral cavity (2 per cent), and in 14 of 275 patients with cancer of the oropharynx (5 per cent). The five-year and 10-year survival rates of patients with oropharyngeal minor salivary gland carcinoma were 90 per cent. No statistically significant difference was observed between survival rates for oropharyngeal minor salivary gland carcinoma and for oropharyngeal squamous cell carcinoma (p = 0.06). The five- and 10-year survival rates of patients with oral cavity minor salivary gland carcinoma were 75 and 37 per cent, respectively. No statistically significant difference was observed between survival rates for oral cavity minor salivary gland carcinoma and oral cavity squamous cell carcinoma.Patients' survival results correlated well with the clinical stage of their lesions. A significant difference in survival was observed, comparing stage IV with stages I, II and III (p = 0.04). In contrast, no significant relationship was found between either survival and tumour type or survival and treatment. Adjuvant therapy is recommended for patients with grade III adenoid cystic carcinoma with perineural infiltration or intravascular infiltration.

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Non-Keratinizing Squamous Cell Carcinoma from the Nasal Cavity Mimicking Palatal Salivary Gland Tumor: Case Report

The Korean Journal of Oral and Maxillofacial Pathology ◽

10.17779/kaomp.2021.45.4.005 ◽

2021 ◽

Vol 45 (4) ◽

pp. 139-144

Author(s):

Hwangyu Lee ◽

◽

Dawool Han ◽

Hyounmin Kim ◽

Dongwook Kim

Keyword(s):

Squamous Cell Carcinoma ◽

Salivary Gland ◽

Case Report ◽

Nasal Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Salivary Gland Tumor ◽

Gland Tumor ◽

Keratinizing Squamous Cell Carcinoma

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Primary squamous cell carcinoma of major salivary gland: “Sapienza Head and Neck Unit” clinical recommendations

Rare Tumors ◽

10.1177/2036361320973526 ◽

2020 ◽

Vol 12 ◽

pp. 203636132097352

Author(s):

Silvia Mezi ◽

Giulia Pomati ◽

Andrea Botticelli ◽

Francesca De Felice ◽

Daniela Musio ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Salivary Gland ◽

Cell Carcinoma ◽

Squamous Cell ◽

Salivary Gland Tumor ◽

Genetic Alterations ◽

Integrated Treatment ◽

Molecular Profile ◽

Major Salivary Gland ◽

Primary Squamous Cell Carcinoma

Primary squamous cell carcinoma of salivary gland (SCG) is an extremely rare type of malignant salivary gland tumor, which in turn results in scarcity of data available regarding both its treatment and associated genetic alterations. A retrospective analysis of 12 patients with primary SCG was conducted, along with analysis of the association between treatment, clinical/pathological characteristics, and outcomes. Most patients (8) were staged IVa, with the majority of them (10) having G3 fast growing cancer. Local and systemic recurrence were reported in only three out of nine parotid cases (0 out of 2 submandibular SCGs). In two out of eight patients local relapse occurred after integrated treatment, while recurrence occurred in two out of three patients undergoing exclusive surgery. Five patients eventually died. Treatment of resectable disease must be aggressive and multimodal, with achievement of loco-regional control in order to reduce rate of recurrence and improve outcomes. Metastatic disease would require a therapeutic strategy tailored to the molecular profile in order to improve the currently disappointing results.

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Abstract 1499: Role of mutations and expression change of mitochondrial function related nuclear genes in oral gingivobuccal squamous cell carcinoma

10.1158/1538-7445.am2017-1499 ◽

2017 ◽

Cited By ~ 1

Author(s):

Esita Chattopadhyay ◽

Richa Singh ◽

Roshni Roy ◽

Bidyut Roy

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Mitochondrial Function ◽

Nuclear Genes ◽

Expression Change

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Squamous cell carcinoma of salivary gland origin

Head & Neck Surgery ◽

10.1002/hed.2890090407 ◽

1987 ◽

Vol 9 (4) ◽

pp. 235-240 ◽

Cited By ~ 37

Author(s):

Larry J. Shemen ◽

Andrew G. Huvos ◽

Ronald H. Spiro

Keyword(s):

Squamous Cell Carcinoma ◽

Salivary Gland ◽

Cell Carcinoma ◽

Squamous Cell

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R413 – KITENIN Enhances Invasion and Metastasis in FOM Cancer Model

Otolaryngology ◽

10.1016/j.otohns.2008.05.567 ◽

2008 ◽

Vol 139 (2_suppl) ◽

pp. P181-P182

Author(s):

Joon Kyoo Lee

Keyword(s):

Squamous Cell Carcinoma ◽

Salivary Gland ◽

Cell Carcinoma ◽

Lung Metastasis ◽

Squamous Cell ◽

Tumor Invasion ◽

Lung Metastases ◽

Cancer Model ◽

Floor Of Mouth ◽

Diffuse Lung

Problem KAI1 is a metastatic suppressor gene. The expression of KAI1 in cancer cells results in reduced cell motility and invasiveness. A cDNA clone of VANGL1, a member of the tetraspanin protein family that specifically interacts with the COOH-terminal cytoplasm domain of KAI1, was isolated and renamed KITENIN (KAI1 COOH-terminal interacting tetraspanin). KITENIN is reported to promote metastasis in a mouse colon cancer model. The purpose of this study was to investigate tumor invasiveness and early lung metastasis by KITENIN in murine floor of mouth cancer model. Methods The cDNA of KITENIN and the vector only were transfected into the SCC VII (mouse squamous cell carcinoma cell line) cells. The transfections were performed using the FuGENE 6 transfection reagent. The suspension of 5 × 105/? viable KITENIN- or vector-transfected SCC VII cells were injected into the floor of mouth of C3H/HeJ syngeneic mice deep to the mylohyoid muscle via an intra-oral approach. From the 1st week to 6th week after injection, tumor, lung, liver, and brain tissues were obtained from six mice each group every week and were evaluated under the light microscope. Results On each group, the tumor invaded to superficial musculature of floor of mouth, deep musculature of floor of mouth, salivary gland, perineural tissue, bone, and skin sequentially. Lung metastases started from peripheral and localized region and moved to central and diffuse lung tissues. Earlier and more aggressive tumor invasion to deep floor of mouth musculature, salivary gland, perineural tissue, bone, and skin was observed in KITENIN-transfected group than in vector group. Earlier and more diffuse lung metastasis was observed in KITENIN group. Conclusion KITENIN enhanced tumor invasion and lung metastasis in murine floor of mouth squamous carcinoma model. Significance An antisense KITENIN strategy could be used to inhibit distant metastasis and progression in head and neck squamous cell carcinoma. Support This study was supported by a grant CUHRICM-CRI07038-1.

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