From among a great number of digestive system diseases in domestic animals there is pancreatitis which is caused by an early zymogenesis in the acinar cells. The problem of studying the structural organization of a pancreata in sick cats is topical because of a progressive spreading of pancreatitis in domestic animals. Thus, the purpose of the research was to study out the morphological changes of cats pancreata under acute pancreatitis. Working with vertebrate animals we were guided by “European Convention for the Protection of Vertebtate Animals used for Experimental and other Scientific Purposes” (Strasbourg, 1986). The results of the histological examination of cats pancreata under acute pancreatitis show some pathological changes both in endocrine and exocrine pancreas. Such changes were manifested in necrosis of exocrine pancreatitis as well as in spreading and swelling of acinar space, that testified to the infancy of an inflammatory process. Some dystrophic changes, followed by karyolysis, were found in the focus of tissue nicrosis. Pancreatocyte cytoplasm was cloudy, its basal and apical zones were obscure, clearly defined interstitial tissue swelling was found between the particles and unequal swelling was found inside the particles. Intercellular space was exaggerated. Morphometrically in a group of sick animals was detected an increase in specific weihgt of stromal component (р<0,05),which equalled 22,44±0,24 %, in a control group it equalled 17,78±0,15 %. Some hemorrhage and distrophicvally changed hormone- active cells as well as nonregular distribution of cells were detected under a histological examination of Langerhans islets. In most islets the cells had swelled vacuolar cytoplasm. While analyzing the morphometric indices it was stated that the cats exocrine pancreas under acute pancreatitis was 1.12 as large and occupied 48258,05±135,07 mkm2, (97,88±0,05 %). The cats endocrine pancreas under this pathology occupied 6858,85±315,05 mkm2, (2,12±0,05 %). In cats of a control group this index equalled 6784,71±285,04 mkm2 (1,95±0,06 %). The diameter of sick cats acinus as well as of Langerhans islets equalled respectively 31,85±0,05 and 71,81±2,45 mkm, which reliably (р<0,001) was 1.13 and 1.15 as large. In clinically healhty cats these indices are 28,12±0,11; 70,20±2,48 mkm.
Obesity causes PGC-1α deficiency in exocrine pancreas leading to IL-6 upregulation via NF-κB in acute pancreatitis
