Immune responses in the Japanese pufferfish (Takifugu rubripes) head kidney cells stimulated with particulate silica

2016 ◽  
Vol 49 ◽  
pp. 84-90 ◽  
Author(s):  
Takashi Morimoto ◽  
Gouranga Biswas ◽  
Tomoya Kono ◽  
Masahiro Sakai ◽  
Jun-ichi Hikima
Keyword(s):  
Immune Responses ◽  
Head Kidney ◽  
Takifugu Rubripes ◽  
Kidney Cells ◽  
Head Kidney Cells ◽  
Particulate Silica

Inflammatory responses in the Japanese pufferfish (Takifugu rubripes) head kidney cells stimulated with an inflammasome-inducing agent, nigericin

2014 ◽  
Vol 46 (2) ◽  
pp. 222-230 ◽  
Author(s):  
Soner Bilen ◽  
Gouranga Biswas ◽  
Shohei Otsuyama ◽  
Tomoya Kono ◽  
Masahiro Sakai ◽  
...  
Keyword(s):  
Inflammatory Responses ◽  
Head Kidney ◽  
Takifugu Rubripes ◽  
Kidney Cells ◽  
Head Kidney Cells

scholarly journals Extracellular ATP is a potent signaling molecule in the activation of the Japanese flounder (Paralichthys olivaceus) innate immune responses

2020 ◽  
Vol 26 (5) ◽  
pp. 413-423 ◽  
Author(s):  
Shuo Li ◽  
Xiaoli Chen ◽  
Jiafang Li ◽  
Xuejing Li ◽  
Tianxu Zhang ◽  
...  
Keyword(s):  
Immune Responses ◽  
Immune Cells ◽  
Inflammatory Cytokine ◽  
Paralichthys Olivaceus ◽  
Head Kidney ◽  
Japanese Flounder ◽  
Innate Immune ◽  
Kidney Cells ◽  
Innate Immune Responses ◽  
Head Kidney Cells

Innate immunity is the first line of defense against pathogen infections. Extracellular ATP (eATP) is one of the most studied danger-associated molecular pattern molecules that can activate host innate immune responses through binding with and activating purinergic receptors on the plasma membrane. The detailed actions of eATP on fish innate immunity, however, remain poorly understood. In this study, we investigated bacterial pathogen-induced ATP release in head kidney cells of the Japanese flounder Paralichthys olivaceus. We also examined the actions of eATP on pro-inflammatory cytokine and immune-related gene expression, the activity of induced NO synthase (iNOS), and the production of reactive oxygen species (ROS) and NO in Japanese flounder immune cells. We demonstrate that ATP is dynamically released from Japanese flounder head kidney cells into the extracellular milieu during immune challenge by formalin-inactivated Edwardsiella tarda and Vibrio anguillarum. In addition, we show that eATP administration results in profound up-regulation of pro-inflammatory cytokine gene expression, iNOS activity, and inflammatory mediator production, including ROS and NO, in Japanese flounder immune cells. Altogether, our findings demonstrate that eATP is a potent signaling molecule for the activation of innate immune responses in fish.

Immunomodulation of Lactobacillus pentosus PL11 against Edwardsiella tarda infection in the head kidney cells of the Japanese eel (Anguilla japonica)

2016 ◽  
Vol 54 ◽  
pp. 466-472 ◽  
Author(s):  
Biruk Tesfaye Birhanu ◽  
Joong-Su Lee ◽  
Seung-Jin Lee ◽  
Su-Hee Choi ◽  
Md. Akil Hossain ◽  
...  
Keyword(s):  
Head Kidney ◽  
Anguilla Japonica ◽  
Japanese Eel ◽  
Edwardsiella Tarda ◽  
Kidney Cells ◽  
Lactobacillus Pentosus ◽  
Head Kidney Cells

scholarly journals Draft Genome Sequence of Epilithonimonas sp. FP211-J200, Isolated from an Outbreak Episode on a Rainbow Trout (Oncorhynchus mykiss) Farm

2017 ◽  
Vol 5 (37) ◽  
Author(s):  
Manuel Ayala ◽  
Cristopher Segovia ◽  
Rodrigo Rojas ◽  
Claudio Miranda ◽  
Javier Santander
Keyword(s):  
Rainbow Trout ◽  
Oncorhynchus Mykiss ◽  
Genome Sequence ◽  
Draft Genome ◽  
Head Kidney ◽  
Fish Host ◽  
Draft Genome Sequence ◽  
Kidney Cells ◽  
Rainbow Trout Oncorhynchus Mykiss ◽  
Head Kidney Cells

ABSTRACT Here, we report the draft genome sequence of Epilithonimonas sp. FP211-J200, isolated from rainbow trout head kidney cells. The size of the genome is 4,110,772 bp, with a G+C content of 37.1%. The Epilithonimonas sp. FP211-J200 genome has genes related to tetracycline and β-lactam resistance. This is the first reported Epilithonimonas species genome isolated from a fish host.

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