In this research, a thermo-sensitive copolymer PNIPAAm-co-MHq was used to successfully synthesize different nano sizes silver nanoparticles in the ranges between 1.5 to 4 nm with uniform dispersion. The polymeric assisted synthesized Ag nanoparticles (AgNPs@PM) exhibited reasonable
solution stability and thermalresponsive behaviour. In specific, AgNPs@PM3 (1.59 nm) displayed improved bacterial resistance against clinically approved anti-biotic resistant bacterial pathigens with very low MIC value (4.05 μg/mL). Subsequently, the thermal responsive
polymeric molecular structure on AgNPs synthesis has been established that significant temperature dependened anti-bacterial efficiency. It was also observed that the nonparticipants size, temperature responses and proportion of thermosensitive copolymer also influenced the antibacterial efficacy
of AgNPs@PM. Resulting thermal sensitive polymer nanocomposite can be extremely beneficial for wound healing treatment after femoral fracture surgery.
Silver nanoparticles enhance wound healing in zebrafish (Danio rerio)
