Temperature-sensitive poly(N-isopropylacrylamide) (PNIPAAm) stabilized size controllable synthesis of silver nanoparticles and its improved antimicrobial activity for wound healing and nursing care after femoral fracture during surgery

2021 ◽  
Vol 11 (1) ◽  
pp. 73-84
Author(s):  
Xiaoyun Wang ◽  
Jing Zhang
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Femoral Fracture ◽  
Bacterial Resistance ◽  
Polymer Nanocomposite ◽  
Temperature Sensitive ◽  
Solution Stability ◽  
Uniform Dispersion ◽  
Significant Temperature ◽  
Thermosensitive Copolymer

In this research, a thermo-sensitive copolymer PNIPAAm-co-MHq was used to successfully synthesize different nano sizes silver nanoparticles in the ranges between 1.5 to 4 nm with uniform dispersion. The polymeric assisted synthesized Ag nanoparticles (AgNPs@PM) exhibited reasonable solution stability and thermalresponsive behaviour. In specific, AgNPs@PM3 (1.59 nm) displayed improved bacterial resistance against clinically approved anti-biotic resistant bacterial pathigens with very low MIC value (4.05 μg/mL). Subsequently, the thermal responsive polymeric molecular structure on AgNPs synthesis has been established that significant temperature dependened anti-bacterial efficiency. It was also observed that the nonparticipants size, temperature responses and proportion of thermosensitive copolymer also influenced the antibacterial efficacy of AgNPs@PM. Resulting thermal sensitive polymer nanocomposite can be extremely beneficial for wound healing treatment after femoral fracture surgery.

scholarly journals Advances in Nanotechnology towards Development of Silver Nanoparticle-Based Wound-Healing Agents

2021 ◽  
Vol 22 (20) ◽  
pp. 11272
Author(s):  
Zimkhitha B. Nqakala ◽  
Nicole R. S. Sibuyi ◽  
Adewale O. Fadaka ◽  
Mervin Meyer ◽  
Martin O. Onani ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Silver Nanoparticle ◽  
Broad Spectrum ◽  
Bacterial Resistance ◽  
Wound Care ◽  
Wound Treatment ◽  
Healing Wound ◽  
As Toxicity

Since antiquity, silver-based therapies have been used in wound healing, wound care and management of infections to provide adequate healing. These therapies are associated with certain limitations, such as toxicity, skin discolouration and bacterial resistance, which have limited their use. As a result, new and innovative wound therapies, or strategies to improve the existing therapies, are sought after. Silver nanoparticles (AgNPs) have shown the potential to circumvent the limitations associated with conventional silver-based therapies as described above. AgNPs are effective against a broad spectrum of microorganisms and are less toxic, effective at lower concentrations and produce no skin discolouration. Furthermore, AgNPs can be decorated or coupled with other healing-promoting materials to provide optimum healing. This review details the history and impact of silver-based therapies leading up to AgNPs and AgNP-based nanoformulations in wound healing. It also highlights the properties of AgNPs that aid in wound healing and that make them superior to conventional silver-based wound treatment therapies.

Mussel-inspired immobilization of zwitterionic silver nanoparticles toward antibacterial cotton gauze for promoting wound healing

2021 ◽  
Vol 409 ◽  
pp. 128291
Author(s):  
Jun Xiang ◽  
Ruixin Zhu ◽  
Shiying Lang ◽  
Hui Yan ◽  
Gongyan Liu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Cotton Gauze

BIOSYNTHESIZED SILVER NANOPARTICLES USING CATHARANTHUS ROSEUS AND THEIR ANTIBACTERIAL EFFICACY IN SYNERGY WITH ANTIBIOTICS; A FUTURE ADVANCEMENT IN NANOMEDICINE

2021 ◽  
pp. 116-124
Author(s):  
MONIKA GUPTA
Keyword(s):  
Electron Microscopy ◽  
Silver Nanoparticles ◽  
Catharanthus Roseus ◽  
Leaf Extract ◽  
Research Work ◽  
Resistant Bacteria ◽  
Surface Plasmon Resonance Peak ◽  
Plasmon Resonance Peak ◽  
X Ray ◽  
Uniform Dispersion

Objective: This research work develops an approach to synthesize silver nanoparticles (AgNPs) by reduction of leaf extract of Catharanthus roseus plant. This study produces synthesized nanoparticles that have process-controlled attributes which make their antibiotic action highly efficient. These attributes include smaller size, proper morphology, uniform dispersion, metal ion content, and formation of functional groups. By optimizing the reduction process parameters, AgNPs gain the desired properties.  Methods: The biosynthesis of AgNPs process was performed using reaction of 10% (w/v) C. roseus leaf extract with AgNO3. The optimum conditions and concentration used for synthesis of nanoparticles were: 1 mM AgNO3, pH 5, and temperature 80°C with an incubation time of 72 h. All the above parameters were analyzed by ultraviolet-visible spectrophotometer with the surface plasmon resonance peak obtained at 440 nm. Results: Various characterization techniques were performed, namely, scanning electron microscopy, energy-dispersive X-ray, transmission electron microscopy, photoluminescence study, X-ray diffraction spectroscopy, Fourier transform infrared, dynamic light scattering, and atomic force microscopy. The results obtained from characterization confirmed the spherical morphology of the nanoparticles with size between 50 and 87 nm. In the current investigation, the antimicrobial activity of biosynthesized AgNPs was also determined using minimum inhibitory concentration and zone of inhibition methods against six different bacteria at different doses of AgNPs (100, 150, and 200 μg/ml) alone and also in combination with antibiotic-streptomycin. Conclusion: The results revealed that high concentration of AgNPs inhibits the bacterial growth. Furthermore, AgNPs revealed much stronger antibacterial action in synergy with streptomycin against antibiotic-resistant bacteria.

scholarly journals Glucuronoxylan-mediated silver nanoparticles: green synthesis, antimicrobial and wound healing applications

RSC Advances ◽  
2017 ◽  
Vol 7 (68) ◽  
pp. 42900-42908 ◽  
Author(s):  
Gulzar Muhammad ◽  
Muhammad Ajaz Hussain ◽  
Muhammad Amin ◽  
Syed Zajif Hussain ◽  
Irshad Hussain ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Green Synthesis ◽  
Biological Applications ◽  
Ag Nps

Hydrogel forming polysaccharides are attracting attention for the design of diverse nature silver nanoparticles (Ag NPs) with potential biological applications.

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