Association of XRCC1 Arg399Gln polymorphism with bladder cancer susceptibility: A meta-analysis

Abstract Prostate cancer is one of the most common noncutaneous malignancies in Western countries. Because there has been a debate regarding the relationship between the XRCC1-Arg399Gln and Arg280His polymorphisms and prostate cancer risk, we therefore performed this meta-analysis. The electronic databases PubMed, EMBASE and Medline were searched prior to October 1, 2014. An odds ratio and 95% confidence interval were used to calculate association. Heterogeneity was tested by both a chi-square test and I2statistic. Funnel plots and Egger’s test were used to assess publication bias. All statistical analyses were performed using STATA 12.0 software. A significant association between the XRCC1-Arg399Gln polymorphism and prostate cancer risk was found under a homozygote model and a recessive model. A significant association between XRCC1-Arg280His and prostate cancer risk was found under a heterozygote model and a dominant model. Overall, the results of this meta-analysis show that the XRCC1-Arg399Gln polymorphism may be associated with an increased risk for prostate cancer under the homozygote model and the recessive model. And XRCC1-Arg280His polymorphism is likely to be related with prostate cancer risk under the heterozygote model and the dominant model. Additional larger well-designed studies are needed to validate our results.

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Functional RsaI/PstI Polymorphism in Cytochrome P450 2E1 Contributes to Bladder Cancer Susceptibility: Evidence from a Meta-analysis

Asian Pacific Journal of Cancer Prevention ◽

10.7314/apjcp.2014.15.12.4977 ◽

2014 ◽

Vol 15 (12) ◽

pp. 4977-4982 ◽

Cited By ~ 5

Author(s):

Xiao-Dong Deng ◽

Qin Gao ◽

Bo Zhang ◽

Li-Xia Zhang ◽

Wei Zhang ◽

...

Keyword(s):

Bladder Cancer ◽

Cytochrome P450 ◽

Cancer Susceptibility ◽

Meta Analysis ◽

Cytochrome P450 2E1

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XRCC1 codon 399 polymorphism (RS25487) in the Ukrainian population

Faktori eksperimental'noi evolucii organizmiv ◽

10.7124/feeo.v21.861 ◽

1970 ◽

Vol 21 ◽

pp. 325-329

Author(s):

Ya. M. Mishchuk ◽

Ye. V. Kharkivska ◽

S. V. Serha ◽

S. Ye. Shkliar ◽

V. B. Katrii ◽

...

Keyword(s):

Bladder Cancer ◽

Cancer Risk ◽

Cancer Susceptibility ◽

Control Group ◽

Genotype Distribution ◽

Xrcc1 Gene ◽

Arg399gln Polymorphism ◽

Keywords Bladder Cancer ◽

Hardy Weinberg Equilibrium ◽

Polymorphic Variants

Aim. To estimate the frequency of XRCC1 codon 399 polymorphic variants in bladder cancer patients and in a control group and define association of this polymorphism with a bladder cancer in Ukrainian patients. Methods. We determined the allele frequencies for 111 patients and 92 controls. Genotyping was performed by PCR-RELP method. Results. The distribution of genotypes in control group was: Arg/Arg – 48 % (n=44), Arg/Gln – 41.3 % (n=38), Gln/Gln – 10.7 % (n=10), whereas in group of patients with a bladder cancer the following distribution was observed: Arg/Arg – 56.8 % (n=63), Arg/Gln – 27.9 % (n=31), Gln/Gln – 15.3 % (n=17). Genotype distribution in control group was within Hardy-Weinberg equilibrium (χ2=59.7, p<0.0001), whereas in patient group it was not (χ2=0.172, p=0.678). No significant association was observed between the XRCC1 Arg399Gln polymorphism and bladder cancer risk. Conclusions. It is indicated that XRCC1 codon 399 polymorphism may not contribute to bladder cancer susceptibility in the Ukrainian population. Keywords: bladder cancer, polymorphism, XRCC1 gene, the cancer risk.

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