Abstract. The insulin-like growth factor 1 receptor (IGF1R) plays a vital role in
immunomodulation and muscle and bone growth. The copy number variation (CNV) is
believed to the reason for many complex phenotypic variations. In
this paper, we statistically analyzed the copy number and the expression
profiling in different tissue types of the IGF1R gene using the
422 samples from four Chinese beef cattle breeds, and the mRNA of
IGF1R was widely expressed in nine tissue types of adult cattle (heart,
liver, kidney, muscle, fat, stomach, spleen, lung and testis). Results of CNV and growth traits indicated that the IGF1R CNV
was significantly associated with body weight and body height of Jinnan (JN)
cattle and was significantly associated with body height and hucklebone width
of Qinchuan (QC) cattle, making IGF1R CNV a promising molecular
marker to improve meat production in beef cattle breeding. Bioinformatics
predictions show that the CNV region is highly similar to the human genome,
and there are a large number of transcription factors, DNase I hypersensitive
sites, and high levels of histone acetylation, suggesting that this region may
play a role in transcriptional regulation, providing directions for further
study of the role of bovine CNV and economic traits.
Copy number variation (CNV) in the <i>IGF1R</i> gene across four cattle breeds and its association with economic traits
