A polymorphism linked to elevated levels of interferon-γ is associated with an increased risk of cytomegalovirus disease among Caucasian lung transplant recipients at a single center

2011 ◽  
Vol 30 (5) ◽  
pp. 523-529 ◽  
Author(s):  
Dimitra Mitsani ◽  
M. Hong Nguyen ◽  
Diana M. Girnita ◽  
Kathleen Spichty ◽  
Eun J. Kwak ◽  
...  
Keyword(s):  
Lung Transplant ◽  
Interferon Γ ◽  
Transplant Recipients ◽  
Single Center ◽  
Cytomegalovirus Disease ◽  
Increased Risk ◽  
Lung Transplant Recipients

Pre-transplant cytomegalovirus-specific cellular immunity and risk of viral reactivation following lung transplantation: a prospective cohort study

2020 ◽  
Author(s):  
Mohammed Altaf ◽  
Katie Lineburg ◽  
Pauline Crooks ◽  
Sweera Rehan ◽  
Katherine K Matthews ◽  
...  
Keyword(s):  
Lung Transplant ◽  
Viral Reactivation ◽  
Transplant Recipients ◽  
Post Transplant ◽  
Transplant Patients ◽  
Cell Immunity ◽  
Increased Risk ◽  
Significant Burden ◽  
Lung Transplant Recipients ◽  
Cmv Reactivation

Abstract Cytomegalovirus (CMV) remains a significant burden in lung transplant recipients. Deficiencies in T-cell immunity post-transplant increase the risk of CMV-associated complications. However, it is not clear if underlying poor pre-transplant immunity increases risk. To assess this, we recruited 39 prospective lung transplant patients and performed QuantiFERON-CMV on their peripheral blood. More than a third of prospective CMV-seropositive transplant recipients were CMV non-immune-reactive (CMV-NIR) pre-transplant. CMV-NIR status was associated with a significantly higher incidence of CMV reactivation post-transplant, demonstrating that dysfunctional CMV immunity in prospective lung transplant recipients is associated with an increased risk of viral reactivation post-transplant.

INCIDENCE OF UNDETECTED LUNG NEOPLASMS IN EXPLANTS OF LUNG TRANSPLANT RECIPIENTS: EXPERIENCE OF A SINGLE CENTER

CHEST Journal ◽  
2005 ◽  
Vol 128 (4) ◽  
pp. 342S
Author(s):  
Deborah J. Levine ◽  
Luis Angel ◽  
Andres Pelaez ◽  
Scott Johnson ◽  
John Calhoon ◽  
...  
Keyword(s):  
Lung Neoplasms ◽  
Lung Transplant ◽  
Transplant Recipients ◽  
Single Center ◽  
Lung Transplant Recipients
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