scholarly journals Determination of in vitro antioxidant activity and in vivo antineoplastic effects against Ehrlich ascites carcinoma of methanolic extract of Sphagneticola calendulacea (L.) Pruski

Heliyon ◽  
2021 ◽  
pp. e07228
Author(s):  
Md. Wasim Bari ◽  
Ariful Islam ◽  
Md. Monirul Islam ◽  
Mst Julia Sultana ◽  
Rashida Afroz ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Methanolic Extract ◽  
Ehrlich Ascites Carcinoma ◽  
Ehrlich Ascites ◽  
Sphagneticola Calendulacea ◽  
In Vitro Antioxidant Activity

scholarly journals In vitro and in vivo evaluation of antitumor activity of methanolic extract of Argyreia nervosa leaves on Ehrlich ascites carcinoma

2015 ◽  
Vol 10 (2) ◽  
pp. 399
Author(s):  
Bhawna Sharma ◽  
Isha Dhamija ◽  
Sandeep Kumar ◽  
Hema Chaudhary
Keyword(s):  
Antitumor Activity ◽  
Solid Tumor ◽  
Methanolic Extract ◽  
Ehrlich Ascites Carcinoma ◽  
Ehrlich Ascites ◽  
Wide Range ◽  
Antioxidant Parameters ◽  
Argyreia Nervosa

<p>The herb of importance like <em>Argyreia nervosa</em> has shown wide range of pharmacological activities. Its methanolic extract of <em>A. nervosa</em> has been explored against Ehrlich ascites carcinoma (EAC) induced liquid and solid tumor in mice. Liquid and solid tumors were induced by intraperitoneal and subcutaneous transplantation of EAC cells in Balb/C mice. Significant and dose dependant results are observed when the mice are sacrificed on 15<sup>th</sup> day for estimation of tumor proliferation, hematological, biochemical and hepatic antioxidant parameters. Mean survival time (days) was increased to 36.5 from 20.5 extract treated mice. The extract also showed a decrease (p&lt;0.001) in body weight and percentage reduction in tumor volume respectively when it was evaluated in solid tumor induced mice for a period of 30 days.  From the result it was concluded that the extract has as a potent antitumor activity and that is comparable to 5-fluorouracil.</p><p> </p>

Chemiluminescence determination of the in vivo and in vitro antioxidant activity of RoseOx® and carnosic acid

1999 ◽  
Vol 48 (1) ◽  
pp. 63-67 ◽  
Author(s):  
Alexander I. Kuzmenko ◽  
Rozalia P. Morozova ◽  
Inna A. Nikolenko ◽  
Georgiy V. Donchenko ◽  
Steven L. Richheimer ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Carnosic Acid ◽  
In Vitro Antioxidant Activity

scholarly journals Comparative Characteristics of Determination of Antioxidant Activity of Sea Buckthorn Fruits by Various Methods

2019 ◽  
Vol 8 (4) ◽  
pp. 48-52
Author(s):  
O. V. Trineeva
Keyword(s):  
Antioxidant Activity ◽  
Medicinal Plant ◽  
Plant Material ◽  
Natural Antioxidants ◽  
Sea Buckthorn ◽  
In Vitro Tests ◽  
Medicinal Plant Material

Introduction. Recently, much attention has been paid to the primary assessment of the pharmacological effect of various drugs using in vivo and in vitro tests. It is known that such a medicinal plant as sea buckthorn, in its phytochemical composition is rich in natural antioxidants: carotenoids, tocopherols, flavonoids, ascorbic acid, etc. In some publications there is information about the antioxidant activity of sea buckthorn and fatty oil based on them. However, information on the comparative characteristics of the use of various methods for determining the antioxidant activity of this type of medicinal plant material and the results obtained are not found in the scientific literature.Aim. The aim of this work was a comparative determination of the antioxidant activity of medicinal plant material of buckthorn fruits of various species of buckthorn.Materials and methods. The total antioxidant activity of water and water-alcohol extracts from the fruits of sea buckthorn fruits was determined using various techniques recommended in the literature. The antioxidant activity of the extracts was determined by permanganometric titration, in vitro inhibition of adrenaline autooxidation, and also in a biological model, Parametium caudatum cell culture.Results and discussion. The effect of the extractant polarity on the value of antioxidant activity was studied. It was found that the highest content of antioxidants in the extraction is observed when using 96 % ethanol as an extractant.Conclusion. Using three methods, the prospects of using sea buckthorn fruits and preparations based on them as a source of antioxidants are shown. 

Chaptalia nutans Polak: Root Extract Has High In Vitro Antioxidant Activity and Low Cytotoxicity In Vivo

2020 ◽  
Author(s):  
Letiele Bruck de Souza ◽  
Amanda Leitão Gindri ◽  
Thainara de Andrade Fortes ◽  
Jefferson Enderle ◽  
Rafael Roehrs ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Root Extract ◽  
Low Cytotoxicity ◽  
In Vitro Antioxidant Activity

In vitro antioxidant activity and in vivo photoprotective effect of a red orange extract

1998 ◽  
Vol 20 (6) ◽  
pp. 331-342 ◽  
Author(s):  
A. Saija ◽  
A. Tomaino ◽  
R. Lo Cascio ◽  
P. Rapisarda ◽  
J.C. Dederen
Keyword(s):  
Antioxidant Activity ◽  
In Vitro Antioxidant Activity

THE ENZYMIC FORMATION OF 6-(METHYLMERCAPTO)PURINE RIBONUCLEOSIDE 5′-PHOSPHATE

1966 ◽  
Vol 44 (2) ◽  
pp. 229-245 ◽  
Author(s):  
Ian C. Caldwell ◽  
J. Frank Henderson ◽  
A. R. P. Paterson
Keyword(s):  
Tumor Cells ◽  
Blood Cells ◽  
Intraperitoneal Injection ◽  
Ehrlich Ascites Carcinoma ◽  
Carcinoma Cells ◽  
Ehrlich Ascites ◽  
Mouse Tissues ◽  
Enzymatic Methods

6-(Methylmercapto)purine ribonucleoside (Me6MPR) is efficiently phosphorylated in mouse tissues and in Ehrlich ascites carcinoma cells in vivo; tumor cells in vitro and cell-free extracts of the tumor also phosphorylate this analogue ribonucleoside. The product of this reaction has been identified by chemical and enzymatic methods and by its chromatographic behaviour as Me6MPR 5′-phosphate. The evidence presented in this report indicates that no other major metabolites of Me6MPR are formed.The phosphorylation of Me6MPR by cell-free tumor extracts requires ATP and Mn2+ (or Mg2+), and evidence is presented that the reaction is probably mediated by adenosine kinase.Me-14C-6MPR is rapidly taken up by most mouse tissues following its intraperitoneal injection. Forty minutes after injection of the labeled drug, the highest levels of radioactivity were found in intestine, liver, blood cells, lung, and spleen, in descending order; virtually no radioactivity was found in brain tissue or in blood plasma.

scholarly journals Betulin-3,28-diphosphate as a Component of Combination Cytostatic Drugs for the Treatment of Ehrlich Ascites Carcinoma In Vitro and In Vivo Experiments

2018 ◽  
Vol 86 (2) ◽  
pp. 17 ◽  
Author(s):  
Olga Vorobyova ◽  
Olga Deryabina ◽  
Darina Malygina ◽  
Nadezhda Plotnikova ◽  
Anna Solovyeva ◽  
...  
Keyword(s):  
Ehrlich Ascites Carcinoma ◽  
Cytostatic Drugs ◽  
In Vivo Experiments ◽  
Ehrlich Ascites

scholarly journals Simultaneous Determination of the Traditional Herbal Formula Ukgansan and the In Vitro Antioxidant Activity of Ferulic Acid as an Active Compound

Molecules ◽  
2018 ◽  
Vol 23 (7) ◽  
pp. 1659 ◽  
Author(s):  
Yu Kim ◽  
Soo-Jin Jeong ◽  
Chang-Seob Seo ◽  
Hye-Sun Lim ◽  
Eunjin Sohn ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Ferulic Acid ◽  
Simultaneous Determination ◽  
Active Compound ◽  
Herbal Formula ◽  
In Vitro Antioxidant Activity

In vitro antioxidant activity and in vivo antidepressant-like effect of α-(phenylselanyl) acetophenone in mice

2012 ◽  
Vol 102 (1) ◽  
pp. 21-29 ◽  
Author(s):  
Mariana Freire Barbieri Gerzson ◽  
Francine N. Victoria ◽  
Cátia S. Radatz ◽  
Marcelo G. de Gomes ◽  
Silvana P. Boeira ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
In Vitro Antioxidant Activity
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