scholarly journals Neurocognitive domains and neuropathological changes in experimental infection with Trypanosoma brucei brucei in Wistar rats

Heliyon ◽  
2021 ◽  
pp. e08260
Author(s):  
Olamide E. Adebiyi ◽  
Temitayo Omobowale ◽  
Mathew Abatan
Keyword(s):  
Trypanosoma Brucei ◽  
Experimental Infection ◽  
Wistar Rats ◽  
Trypanosoma Brucei Brucei

Effects of n-hexane and ethylacetate fractions of Terminalia catappa leaf extract in experimental Trypanosoma brucei brucei infection in Wistar rats

2021 ◽  
Author(s):  
Folashade Sarah Ojeleye ◽  
Helen Ileigo Inabo ◽  
Clement Myah Zaman Whong ◽  
Bolanle Olufunke Priscilla Musa ◽  
Ochuko Orakpoghenor
Keyword(s):  
Trypanosoma Brucei ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Trypanosoma Brucei Brucei ◽  
Terminalia Catappa

scholarly journals Effect of Leaf Extract of Senna alata on Biochemical Indices of Wistar Rats Infected with Trypanosoma brucei brucei

2020 ◽  
pp. 10-19
Author(s):  
M. A. Kugama ◽  
T. Tese ◽  
H. Sabo ◽  
T. Andrew ◽  
Y. A. Onaolapo ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Wistar Rats ◽  
Methanol Extract ◽  
Potassium Concentration ◽  
Sodium Concentration ◽  
Chloroform Extract ◽  
Trypanosoma Brucei Brucei ◽  
Infection Treatment ◽  
Biochemical Indices ◽  
Senna Alata

This study was aimed at determining the effect of leaves of Senna alata extract on biochemical indices of Wistar rats infected with Trypanosoma brucei brucei. Phytochemical screening revealed the absence of steroids in all extracts, absence of saponins in chloroform extracts and the presence of free anthraquinones only in chloroform extract. Post-infection treatment of animals stirred the emergence of parasitaemia by Day 3. Only animals receiving 200 mg/kg b.wt. of chloroform extract survived by day 16. A significant (P<0.05) decrease in ALT for groups receiving methanol (400 mg/kg b.wt.), chloroform and aqueous extracts and significant (P<0.05) increase in unconjugated bilirubin in the group receiving methanol extract (200 mg/kg b.wt.) compared to infected not treated rats. Significant (P<0.05) decrease in potassium concentration in groups receiving methanol and chloroform, and a significant (P<0.05) increase in sodium concentration in the group receiving 400 mg/kg b.wt. of aqueous extract compared to the infected not treated rats. These results thereby demonstrate the ameliorative potential of Senna alata leaves against T. brucei brucei.

Flavonoid mixture ameliorates increase in erythrocyte osmotic fragility and malondialdehyde concentration induced by Trypanosoma brucei brucei-infection in Wistar rats

2014 ◽  
Vol 96 (1) ◽  
pp. 139-142 ◽  
Author(s):  
Patricia I. Kobo ◽  
Joseph O. Ayo ◽  
Tagang Aluwong ◽  
Abdulkadir U. Zezi ◽  
Victor Maikai ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Wistar Rats ◽  
Osmotic Fragility ◽  
Trypanosoma Brucei Brucei ◽  
Erythrocyte Osmotic Fragility

Major acute phase response of haptoglobin and serum amyloid-P following experimental infection of mice with Trypanosoma brucei brucei

1997 ◽  
Vol 46 (4) ◽  
pp. 247-254 ◽  
Author(s):  
Raphael M. Ngure ◽  
P. David Eckersall ◽  
Francis W. Jennings ◽  
Joanne M. Burke ◽  
Michael J. Stear ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Acute Phase ◽  
Experimental Infection ◽  
Acute Phase Response ◽  
Phase Response ◽  
Serum Amyloid ◽  
Trypanosoma Brucei Brucei ◽  
Serum Amyloid P ◽  
Amyloid P

scholarly journals Haematological changes in Wistar rats experimentally infected with Trypanosoma congolense and Trypanosoma brucei brucei obtained from North-west Nigeria

2021 ◽  
Vol 19 (2) ◽  
pp. 73-80
Author(s):  
A.O. Fajinmi ◽  
O.O. Faleke ◽  
A.A. Magaji ◽  
U.M. Chafe ◽  
M.A. Kassim ◽  
...  
Keyword(s):  
Blood Cell ◽  
Trypanosoma Brucei ◽  
Wistar Rats ◽  
Trypanosoma Congolense ◽  
Control Group ◽  
Blood Cell Count ◽  
Trypanosoma Brucei Brucei ◽  
Group A ◽  
Haematological Changes ◽  
Group D

This study determined haematological changes in Wistar rats experimentally infected with local strains of Trypanosoma congolense and Trypanosoma brucei brucei. Forty-five Wistar rats between 10 – 12 weeks old weighing between 210 – 240 g were used. The Wistar rats were randomly divided into four groups (A, B, C and D), with the infected groups (B, C and D) having 10 rats each, while the uninfected control group (A) had 15 rats. Group A rats were not infected and served as the control, group B were infected with Trypanosoma congolense, group C were infected with Trypanosoma brucei brucei and group D were co-infected with Trypanosoma congolense and Trypanosoma brucei brucei. Infection was achieved using 0.1mL of blood containing approximately 1 × 103 trypanosomes intraperitoneally into each Wistar rat in the infected groups. Clinical signs were observed. The changes in the blood cells were assayed in the groups post-infection. Duncan’s Least Square Deviation showed significantly (p<0.05) higher parasitaemia in infected groups. However, group D showed a higher significant (p<0.05) difference in parasitaemia when compared to groups B and C. The pattern of mean parasitaemia for the infected groups, revealed a positive correlation with days of post-infection (p<0.05) before the decline. The packed cell volume, total red blood cell count and haemoglobin concentration were significantly (p<0.05) lower in infected groups B, C and D. The total white blood cell count, platelet counts and differential leucocyte count were significantly (p<0.05) lower in infected groups when compared to the uninfected group. These findings suggest that co-infection with Trypanosoma congolense and Trypanosoma brucei brucei obtained from Wurno and Ngaski in Sokoto and Kebbi States respectively produced a more damaging effect on haematological parameters.

scholarly journals In vitro assay and in vivo effect of artemisinin in Trypanosoma brucei brucei-infected Wistar rats

2021 ◽  
Vol 1 (3) ◽  
pp. 100061
Author(s):  
Kelvin Olutimilehin Jolayemi ◽  
Mohammed Mamman ◽  
Dahiru Sani ◽  
Magdalene Ogbonneya Okoronkwo ◽  
Abubakar Usman ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Wistar Rats ◽  
In Vitro Assay ◽  
Trypanosoma Brucei Brucei ◽  
Vitro Assay
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