Screening study of enzymatic inhibition of medicinal plants for the treatment of diabetes using a glucometer biosensor approach and optical method

2021 ◽  
Vol 28 ◽  
pp. 100441
Author(s):  
Raouia Attaallah ◽  
Dounia Elfadil ◽  
Aziz Amine
Keyword(s):  
Medicinal Plants ◽  
Optical Method ◽  
Enzymatic Inhibition ◽  
Screening Study ◽  
Treatment Of Diabetes

Ethnobotanical Survey of Medicinal Plants Used for the Treatment of Diabetes in Manisa (Turkey)

2013 ◽  
Vol 4 (1) ◽  
pp. 288-288 ◽  
Author(s):  
Cenk Durmuşkahya ◽  
Münir Öztürk
Keyword(s):  
Medicinal Plants ◽  
Ethnobotanical Survey ◽  
Treatment Of Diabetes

scholarly journals Glycogen Phosphorylase-a is a Common Target for Anti-Diabetic Effect of Iridoid and Secoiridoid Glycosides

2013 ◽  
Vol 16 (4) ◽  
pp. 530 ◽  
Author(s):  
Hitesh B Vaidya ◽  
Abeer A Ahmed ◽  
Ramesh K Goyal ◽  
Sukhinder K Cheema
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Glycogen Phosphorylase ◽  
Docking Studies ◽  
Chemical Components ◽  
Active Components ◽  
Active Chemical ◽  
Treatment Of Diabetes ◽  
Secoiridoid Glycosides ◽  
Common Target

Purpose. Diabetes mellitus is characterized by hyperglycemia resulting from defects in insulin secretion, action or both. The use of medicinal plants for the treatment of diabetes mellitus dates back from the Ebers papyrus of about 1550 B.C. One of the major problems with herbal drugs is that the active ingredients are not well defined. It is important to know the active components and their molecular interactions which will help to analyze their therapeutic efficacy and also to standardize the product. There are a number of medicinal plants known for their anti-diabetic effect that possess similarities in their active chemical components, e.g. iridoid and secoiridoid glycosides. Methods. In this study, we have compared the structure of various iridoid and secoiridoid glycosides to design a novel pharmacophore. We further developed a structure-activity relationship for the inhibition of glycogen phosphorylase-a. Conclusion. By using docking studies, we are proposing, for the first time, that inhibition of glycogen phosphorylase-a activity is a common target for iridoids and secoiridoids to elicit anti-diabetic effects. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

scholarly journals Medicinal importance of Kaempferia galanga L. (Zingiberaceae): A comprehensive review

2021 ◽  
Vol 10 (3) ◽  
pp. 281-288
Author(s):  
Aswin Rafif Khairullah ◽  
Tridiganita Intan Solikhah ◽  
Arif Nur Muhammad Ansori ◽  
Ristag Hamida Hanisia ◽  
Gavrila Amadea Puspitarani ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Traditional Medicine ◽  
Southeast Asian ◽  
Asian Countries ◽  
Comprehensive Review ◽  
Methanol Extracts ◽  
Kaempferia Galanga ◽  
Joint Fractures ◽  
Treatment Of Diabetes ◽  
Southeast Asian Countries

Kaempferia galanga included in the Zingiberaceae family is one of the potential medicinal plants with aromatic rhizome. In traditional medicine in Asian countries, this plant is widely used by local practitioners. This plant is widely cultivated in most Southeast Asian countries such as Cambodia, Vietnam, Malaysia, Thailand, and Indonesia. Ethyl-para-methoxycinnamate and ethyl-cinnamate are found as the main compounds in hexane, dichloromethane, and methanol extracts of K. galanga. This plant is traditionally used as an expectorant, stimulant, diuretic, carminative, and antipyretic remedy. In addition, K. galanga is used for treatment of diabetes, hypertension, cough, asthma, joint fractures, rheumatism, urticaria, vertigo, and intestinal injuries. Therefore, this study aimed to give a sneak peek view on galangal’s ethnobotany, toxicology, pharmacology, and phytochemistry.

scholarly journals TRADITIONAL MEDICINAL PLANTS USED IN THE TREATMENT OF DIABETES MELLITUS: A REVIEW

2019 ◽  
Vol 10 (11) ◽  
pp. 1-4
Author(s):  
Selemun Hagos ◽  
Abraha Teklay ◽  
Gebrehiwot Gebretsadik
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Traditional Medicinal Plants ◽  
Treatment Of Diabetes

scholarly journals A review of Algerian medicinal plants used in the treatment of diabetes

2019 ◽  
Vol 238 ◽  
pp. 111841 ◽  
Author(s):  
Nawel Hamza ◽  
Bénédicte Berke ◽  
Anwar Umar ◽  
Catherine Cheze ◽  
Henri Gin ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Treatment Of Diabetes

scholarly journals Metabolic and Epigenetic Action Mechanisms of Antidiabetic Medicinal Plants

2019 ◽  
Vol 2019 ◽  
pp. 1-18 ◽  
Author(s):  
Siba Shanak ◽  
Bashar Saad ◽  
Hilal Zaid
Keyword(s):  
Medicinal Plants ◽  
Glucose Absorption ◽  
Review Article ◽  
Cellular Systems ◽  
Action Mechanisms ◽  
Mechanistic Insight ◽  
Gene Environment ◽  
Reduced Physical Activity ◽  
Blood Glucose Homeostasis ◽  
Treatment Of Diabetes

Diabetes is a predominant metabolic disease nowadays due to the off-beam lifestyle of diet and reduced physical activity. Complications of the illness include the gene-environment interactions and the downstream genetic and epigenetic consequences, e.g., cardiovascular diseases, tumor progression, retinopathy, nephropathy, neuropathy, polydipsia, polyphagia, polyuria, and weight loss. This review sheds the light on the mechanistic insights of antidiabetic medicinal plants in targeting key organs and tissues involved in regulating blood glucose homeostasis including the pancreas, liver, muscles, adipose tissues, and glucose absorption in the intestine. Diabetes is also involved in modulating major epigenetic pathways such as DNA methylation and histone modification. In this respect, we will discuss the phytochemicals as current and future epigenetic drugs in the treatment of diabetes. In addition, several proteins are common targets for the treatment of diabetes. Some phytochemicals are expected to directly interact with these targets. We lastly uncover modeling studies that predict such plausible interactions. In conclusion, this review article presents the mechanistic insight of phytochemicals in the treatment of diabetes by combining both the cellular systems biology and molecular modeling.

scholarly journals A REVIEW ON PROMISING ANTI-DIABETIC MEDICINAL PLANTS FOR TREATMENT OF DIABETES MELLITUS

2019 ◽  
Vol 10 (3) ◽  
pp. 20-24
Author(s):  
V S Mule ◽  
N S Naikwade
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Treatment Of Diabetes

scholarly journals Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

Planta Medica ◽  
2011 ◽  
Vol 77 (11) ◽  
pp. 1210-1220 ◽  
Author(s):  
Fatma Afifi-Yazar ◽  
Violet Kasabri ◽  
Rana Abu-Dahab
Keyword(s):  
Medicinal Plants ◽  
Traditional Uses ◽  
Treatment Of Diabetes

Medicinal plants and the treatment of diabetes in Senegal: survey with patients

2008 ◽  
Vol 22 (2) ◽  
pp. 211-216 ◽  
Author(s):  
Amadou Moctar Dièye ◽  
Anna Sarr ◽  
Saïd Norou Diop ◽  
Mamadou Ndiaye ◽  
Guata Yoro Sy ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Treatment Of Diabetes
Sign in / Sign up

Export Citation Format

Share Document