scholarly journals Metabolic and Epigenetic Action Mechanisms of Antidiabetic Medicinal Plants

2019 ◽  
Vol 2019 ◽  
pp. 1-18 ◽  
Author(s):  
Siba Shanak ◽  
Bashar Saad ◽  
Hilal Zaid
Keyword(s):  
Medicinal Plants ◽  
Glucose Absorption ◽  
Review Article ◽  
Cellular Systems ◽  
Action Mechanisms ◽  
Mechanistic Insight ◽  
Gene Environment ◽  
Reduced Physical Activity ◽  
Blood Glucose Homeostasis ◽  
Treatment Of Diabetes

Diabetes is a predominant metabolic disease nowadays due to the off-beam lifestyle of diet and reduced physical activity. Complications of the illness include the gene-environment interactions and the downstream genetic and epigenetic consequences, e.g., cardiovascular diseases, tumor progression, retinopathy, nephropathy, neuropathy, polydipsia, polyphagia, polyuria, and weight loss. This review sheds the light on the mechanistic insights of antidiabetic medicinal plants in targeting key organs and tissues involved in regulating blood glucose homeostasis including the pancreas, liver, muscles, adipose tissues, and glucose absorption in the intestine. Diabetes is also involved in modulating major epigenetic pathways such as DNA methylation and histone modification. In this respect, we will discuss the phytochemicals as current and future epigenetic drugs in the treatment of diabetes. In addition, several proteins are common targets for the treatment of diabetes. Some phytochemicals are expected to directly interact with these targets. We lastly uncover modeling studies that predict such plausible interactions. In conclusion, this review article presents the mechanistic insight of phytochemicals in the treatment of diabetes by combining both the cellular systems biology and molecular modeling.

scholarly journals A REVIEW ON ROLE OF ANTIOXIDANTS IN DIABETES

2018 ◽  
Vol 11 (2) ◽  
pp. 48 ◽  
Author(s):  
Deepa Rajendiran ◽  
Subbulakshmi Packirisamy ◽  
Krishnamoorthy Gunasekaran
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Metabolic Disease ◽  
Medicinal Plants ◽  
Major Part ◽  
Review Article ◽  
Hypoglycemic Activity ◽  
Antioxidants Activity ◽  
Treatment Of Diabetes

 Diabetes mellitus is a chronic metabolic disease. Oxidative stress plays a major part in the pathogenesis of diabetes. Supplementation with antioxidants and the medicinal plants which possess antioxidants activity have been reported their hypoglycemic activity. The antioxidants are used to treat and reduce the complication of diabetes mellitus. The diet supplementations of antioxidants vitamins are beneficial in the treatment of diabetes. This review article was summarizing the role of antioxidants in diabetes mellitus.

Berberine in the treatment of diabetes mellitus: a review

2020 ◽  
Vol 20 ◽  
Author(s):  
Aleksandra Baska ◽  
Kamil Leis ◽  
Przemysław Gałązka
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Intestinal Flora ◽  
Glucose Absorption ◽  
Hepatocyte Nuclear Factor ◽  
Peripheral Tissues ◽  
Macrophages Polarization ◽  
Treatment Of Diabetes ◽  
Hepatocyte Nuclear Factor 4

: Berberine is an alkaloid found in plants. It has e.g. neuroprotective, anti-inflammatory and hypolipidemic activity. The research proves that it also strongly impacts the carbohydrate metabolism. The compound also protects pancreatic βcells and increases sensitivity to insulin in peripheral tissues via the induction of GLUT-1, GLUT-4 and insulin type 1 (Ins1) receptors activity. It also stimulates glycolysis and leads to a decrease in insulin resistance by macrophages polarization, lipolytic processes induction and energy expenditure enhancement (by reducing body mass and limiting insulin resistance caused by obesity). In liver berberine inhibits FOX01, SREBP1 and ChREBP pathways, and HNF-4α (hepatocyte nuclear factor 4 alpha) mRNA that hinder gluconeogenesis processes. In intestines it blocks α-glucosidase contributing to glucose absorption decrease. Its interference in intestinal flora reduces levels of monosaccharides and suppresses diabetes mellitus complications development.

The role of currently used medicinal plants in aquaculture and their action mechanisms: A review

2021 ◽  
Author(s):  
Dawit Adisu Tadese ◽  
Changyou Song ◽  
Cunxin Sun ◽  
Bo Liu ◽  
Bo Liu ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Action Mechanisms

scholarly journals Glycogen Phosphorylase-a is a Common Target for Anti-Diabetic Effect of Iridoid and Secoiridoid Glycosides

2013 ◽  
Vol 16 (4) ◽  
pp. 530 ◽  
Author(s):  
Hitesh B Vaidya ◽  
Abeer A Ahmed ◽  
Ramesh K Goyal ◽  
Sukhinder K Cheema
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Glycogen Phosphorylase ◽  
Docking Studies ◽  
Chemical Components ◽  
Active Components ◽  
Active Chemical ◽  
Treatment Of Diabetes ◽  
Secoiridoid Glycosides ◽  
Common Target

Purpose. Diabetes mellitus is characterized by hyperglycemia resulting from defects in insulin secretion, action or both. The use of medicinal plants for the treatment of diabetes mellitus dates back from the Ebers papyrus of about 1550 B.C. One of the major problems with herbal drugs is that the active ingredients are not well defined. It is important to know the active components and their molecular interactions which will help to analyze their therapeutic efficacy and also to standardize the product. There are a number of medicinal plants known for their anti-diabetic effect that possess similarities in their active chemical components, e.g. iridoid and secoiridoid glycosides. Methods. In this study, we have compared the structure of various iridoid and secoiridoid glycosides to design a novel pharmacophore. We further developed a structure-activity relationship for the inhibition of glycogen phosphorylase-a. Conclusion. By using docking studies, we are proposing, for the first time, that inhibition of glycogen phosphorylase-a activity is a common target for iridoids and secoiridoids to elicit anti-diabetic effects. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

scholarly journals Medicinal importance of Kaempferia galanga L. (Zingiberaceae): A comprehensive review

2021 ◽  
Vol 10 (3) ◽  
pp. 281-288
Author(s):  
Aswin Rafif Khairullah ◽  
Tridiganita Intan Solikhah ◽  
Arif Nur Muhammad Ansori ◽  
Ristag Hamida Hanisia ◽  
Gavrila Amadea Puspitarani ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Traditional Medicine ◽  
Southeast Asian ◽  
Asian Countries ◽  
Comprehensive Review ◽  
Methanol Extracts ◽  
Kaempferia Galanga ◽  
Joint Fractures ◽  
Treatment Of Diabetes ◽  
Southeast Asian Countries

Kaempferia galanga included in the Zingiberaceae family is one of the potential medicinal plants with aromatic rhizome. In traditional medicine in Asian countries, this plant is widely used by local practitioners. This plant is widely cultivated in most Southeast Asian countries such as Cambodia, Vietnam, Malaysia, Thailand, and Indonesia. Ethyl-para-methoxycinnamate and ethyl-cinnamate are found as the main compounds in hexane, dichloromethane, and methanol extracts of K. galanga. This plant is traditionally used as an expectorant, stimulant, diuretic, carminative, and antipyretic remedy. In addition, K. galanga is used for treatment of diabetes, hypertension, cough, asthma, joint fractures, rheumatism, urticaria, vertigo, and intestinal injuries. Therefore, this study aimed to give a sneak peek view on galangal’s ethnobotany, toxicology, pharmacology, and phytochemistry.

scholarly journals Calotropis procera (Arka): A Tribal Herb of Utmost Significance

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
Isha Kumari ◽  
Gitika Chaudhary
Keyword(s):  
Medicinal Plants ◽  
Review Article ◽  
Calotropis Procera ◽  
Pharmacological Properties ◽  
The Family ◽  
Anti Oxidant ◽  
Phytochemical Constituents ◽  
The Rich ◽  
The Tropics ◽  
Important Medicinal Plant

Nature has gifted humans a vast variety of medicinal plants, which are the rich source of bioactive compounds. Calotropis procera is an important medicinal plant that belongs to the family asclepiadaceae. It is commonly known as madar and milkweed plant in english and arka in hindi. It is mostly found in the tropics of asia and africa. Calotropis procera is a highly valued plant in the folk medication system. Each part of the plant is richly endowed with diverse nature of phytochemical constituents like alkaloids, proteins, vitamins, carbohydrates, saponins, terpenes, and flavonoids, etc. These phytochemicals are significantly associated with various therapeutic and pharmacological properties such as anti-microbial, anti-oxidant, anti-inflammatory, anti-ulcer, antifertility, anti-diarrheal, and spasmolytic. In this review article, the therapeutic and pharmacological value of this important plant has been summarized along with its utilization in the folklore and ayurvedic medicinal system.

scholarly journals Antidiabetic Mechanisms of Rosa canina Fruits

2016 ◽  
Vol 22 (1) ◽  
pp. 127-133 ◽  
Author(s):  
Ali Fattahi ◽  
Fatemeh Niyazi ◽  
Behzad Shahbazi ◽  
Mohammad Hosein Farzaei ◽  
Gholamreza Bahrami
Keyword(s):  
Diabetes Mellitus ◽  
Cell Line ◽  
Mechanism Of Action ◽  
Glucose Absorption ◽  
Rosa Canina ◽  
Glucose Diffusion ◽  
Treatment Of Diabetes ◽  
Hepatocellular Carcinoma Cell Line ◽  
Natural Agent

Rosa canina fruits have been used traditionally for the treatment of diabetes mellitus and its complications. The aim of current study was to evaluate the in vitro mechanism of action of R canina in managing diabetes mellitus. Cell proliferation and cytotoxicity assay were performed on pancreatic β-cells, βTC6. The protective activity of the extract on streptozotocin-induced death in βTC6 cells was studied. The effect of R canina on the metabolism of glucose in HepG2, a hepatocellular carcinoma cell line, was evaluated. The effect of the extract on glucose diffusion across the dialysis membrane, which is a comfortable model for assessing cellular glucose absorption, was evaluated. The results obtained from current study confirmed that R canina extract can act as a growth factor for pancreatic β-cell line providing a novel mechanism for the observed antidiabetic effect of this natural agent. Further preclinical studies are necessary to evaluate the perfect mechanism of action of R canina in diabetes mellitus.

Sign in / Sign up

Export Citation Format

Share Document