scholarly journals One stage laparoscopic parenchymal sparing liver resection for bilobar colorectal liver metatases: Safety, recurrence patterns and oncologic outcomes

HPB ◽  
2020 ◽  
Vol 22 ◽  
pp. S358-S359
Author(s):  
M. D'Hondt ◽  
I. Parmentier ◽  
C. De Meyere ◽  
M. Besselink ◽  
F. Vansteenkiste ◽  
...  
Keyword(s):  
Liver Resection ◽  
Oncologic Outcomes ◽  
One Stage ◽  
Recurrence Patterns

Recurrence Patterns After Anatomic or Parenchyma-Sparing Liver Resection for Hepatocarcinoma in a Western Population of Cirrhotic Patients

2018 ◽  
Vol 25 (13) ◽  
pp. 3974-3981 ◽  
Author(s):  
Simone Famularo ◽  
Stefano Di Sandro ◽  
Alessandro Giani ◽  
Andrea Lauterio ◽  
Marta Sandini ◽  
...  
Keyword(s):  
Liver Resection ◽  
Western Population ◽  
Cirrhotic Patients ◽  
Recurrence Patterns ◽  
Parenchyma Sparing

Sarcomatoid urothelial carcinoma (SUC): A single-institution experience of oncologic outcomes and recurrence patterns.

2020 ◽  
Vol 38 (6_suppl) ◽  
pp. 465-465
Author(s):  
Leonidas Nikolaos Diamantopoulos ◽  
Rishi Robert Sekar ◽  
Ali Raza Khaki ◽  
Brian Winters ◽  
Funda Vakar-Lopez ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Cox Regression ◽  
Multivariable Analysis ◽  
Complete Response ◽  
Oncologic Outcomes ◽  
Time To Recurrence ◽  
Treatment Data ◽  
Recurrence Patterns ◽  
Fluid Collections ◽  
Cystic Masses

465 Background: SUC is a rare histology with aggressive behavior. We evaluated outcomes and recurrence patterns of patients (pts) with SUC, in comparison with conventional urothelial carcinoma (CUC). Methods: We retrospectively assessed our radical cystectomy (RC) database to identify pts with cT2-4 SUC (any %) or CUC, at RC or transurethral resection specimens. Clinicopathologic/treatment data were captured and compared with t and χ2 tests, as appropriate. Overall survival (OS; diagnosis to death) and recurrence-free survival (RFS; RC to recurrence or death) were estimated (KM method). Significant factors in univariable (UVA) Cox regression for OS were included in multivariable analysis (MVA). Results: We identified 38 consecutive pts with cT2-4 SUC and 287 with CUC (2003-2018); 17 (45%) and 162 (56%) received neoadjuvant chemotherapy (NAC). The primary non-mesenchymal component was urothelial in all SUC cases. SUC had higher rates of pT3/4 (66% vs. 35%, p < .001) but comparable rates of pN+ disease (26% vs. 20%, p = .38). Complete response (ypT0N0) after NAC was lower for SUC (6% vs. 35%, p = .02). Median follow-up was 73.6 months (95%CI 62.6 – 84.7). Median RFS and OS was inferior among pts with SUC (9.4 vs 109.8 months, p < .001, 19.7 vs. 130.4 months, p < .001 respectively). On MVA, SUC was independently associated with worse OS ( Table). Of 17 (45%) pts with SUC who recurred post-RC, 5 presented with abdomino-pelvic cystic masses, with an average time to recurrence < 5 months. Conclusions: SUC was associated with high rates of extravesical spread at RC and worse NAC response, RFS and OS, vs. CUC. Development of abdomino-pelvic fluid collections should raise suspicion of recurrence among pts with this histology. [Table: see text]

One-stage Liver Resection for Spontaneous Rupture of Hepatocellular Carcinoma

2005 ◽  
Vol 29 (10) ◽  
pp. 1316-1318 ◽  
Author(s):  
Liu Hai ◽  
Peng Yong-Hong ◽  
Fu Yong ◽  
Li Ren-Feng
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Resection ◽  
Spontaneous Rupture ◽  
One Stage

scholarly journals Patterns, timing, and predictors of recurrence after laparoscopic liver resection for hepatocellular carcinoma: results from a high-volume HPB center

2021 ◽  
Author(s):  
Haili Zhang ◽  
Fei Liu ◽  
Ningyuan Wen ◽  
Bo Li ◽  
Yonggang Wei
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Liver Resection ◽  
Laparoscopic Liver Resection ◽  
Survival Rates ◽  
Surgical Margin ◽  
Trocar Site ◽  
Liver Recurrence ◽  
Risk Factors For Recurrence ◽  
Recurrence Patterns

Abstract Background Although long-term outcomes may be comparable between laparoscopic liver resection (LLR) and open liver resection (OLR) for hepatocellular carcinoma (HCC), there has been little discussion regarding the patterns of recurrence after LLR. Methods Patients with HCC who underwent hepatectomy between April 2015 and November 2018 were included in this study. The recurrence patterns were analyzed in detail. The recurrence outcomes following laparoscopic versus OLR for HCC were compared after 1:2 propensity score matching. Potential risk factors for recurrence were also assessed with Cox proportional risk models. Results Among 425 patients after LLR, 144 (33.8%) experienced recurrence at the last follow-up, with a median recurrence-free survival (RFS) of 10.0 months (range 1–58 months). The most frequent recurrence site was the liver (n = 99, 68.8%), followed by the surgical margin (n = 15, 10.4%) and distant metastases (n = 12, 8.3%). Liver recurrence with distant metastasis (n = 10, 6.9%) tended to occur early (median 8.0 months), while peritoneal recurrence (n = 8, 5.6%) occurred later (median 14.0 months). A total of 120 (83.3%) patients had recurrence within 2 years after LLR. No trocar site recurrence was observed in this study. The recurrence patterns, timing, and treatment did not show significant differences between the LLR and OLR. The independent risk factors for recurrence included ALBI grade, postoperative α-fetoprotein > 8 ng/ml, tumor size > 5 cm, surgical margin ≤ 1 cm, and multiple tumors. Patients with recurrence had 1- and 5-year overall survival rates of 81.1% and 60.7%, respectively, compared with rates of 95.8% and 92.9% for patients without recurrence (P < 0.000). Conclusion This study suggested that intrahepatic recurrence was still the most common recurrence pattern for HCC after LLR and that LLR did not increase the risk of trocar hole recurrence or implantation. Most cases of recurrence occurred within 2 years after LLR, suggesting that surveillance should be targeted to early recurrence.

scholarly journals One stage laparoscopic ICG guided liver resection for bilateral colorectal liver metastases

HPB ◽  
2021 ◽  
Vol 23 ◽  
pp. S992-S993
Author(s):  
M. Barabino ◽  
G. PIccolo ◽  
G. Tarchi ◽  
A. Pisani Ceretti ◽  
E. De Nicola ◽  
...  
Keyword(s):  
Liver Resection ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
One Stage

scholarly journals Treatment Strategy for Dialysis Patient with Urothelial Carcinoma

Diagnostics ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1966
Author(s):  
Yun-Ching Huang ◽  
Yu-Liang Liu ◽  
Miao-Fen Chen ◽  
Chih-Shou Chen ◽  
Chun-Te Wu
Keyword(s):  
Urothelial Carcinoma ◽  
Cox Regression ◽  
Multivariate Logistic Regression Analysis ◽  
Oncologic Outcomes ◽  
Dialysis Patients ◽  
One Stage ◽  
Multi Stage ◽  
Pathologic Features ◽  
Significant Difference ◽  
The One

To investigate postoperative complications and oncologic outcomes of prophylactic nephroureterectomy and/or cystectomy in dialysis patients with urothelial carcinoma (UC), we retrospectively reviewed the records of dialysis patients with UC and a final status of complete urinary tract extirpation (CUTE, i.e., the removal of both kidneys, ureters, and bladder) between January 2004 and December 2015. Patients undergoing dialysis after initial radical nephroureterectomy and/or cystectomy were excluded. Eighty-four and 27 dialysis patients, undergoing one-stage and multi-stage CUTE, were enrolled in this study, respectively. Demographic, medical, perioperative, and pathologic features were collected to determine variables associated with oncologic outcomes. Although there was no significant difference in mortality between the 2 groups (p = 0.333), all 5 (4.5%) patients with Clavien–Dindo grade 5 complications were from the one-stage CUTE group. On multivariate logistic regression analysis, advanced age (p = 0.042) and high Charlson comorbidity index (CCI) (p = 0.000) were related to postoperative major complications. Compared with multi-stage CUTE, one-stage CUTE had no overall, cancer-specific, and recurrence-free survival benefits (all p > 0.05). According to multivariate analysis with Cox regression, age > 70 years (HR 2.70, 95% CI 1.2–6.12; p = 0.017), CCI ≥ 5 (HR 2.16, 95% CI 1.01–4.63; p = 0.048), and bladder cancer stage ≥ 3 (HR 12.4, 95% CI 1.82–84.7; p = 0.010) were independent, unfavorable prognostic factors for the overall survival. One-stage CUTE is not associated with superior oncologic outcomes, and all perioperative mortalities in our series occurred in the one-stage CUTE group. Our data do not support prophylactic nephroureterectomy and/or cystectomy for uremic patients with UC.

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