Effect of double dose plateletpheresis on target yield and donor platelet recovery

Abstract Introduction Multiple myeloma (MM) in very young patients is uncommon, and no treatment guidelines exist for these patients. Patients and Methods We performed a retrospective analysis of five very young myeloma patients who underwent tandem autologous hematopoietic stem cell transplantation (HSCT). Results The median age was 37 years (range = 34–40 years). A median of two leukapheresis was performed (range = 1–4). The median number of hematopoietic stem cells collected was 5.4 × 106/kg (4.4–8.2 × 106/kg). During first transplant, four patients received melphalan of 200 mg/m2 and one patient received melphalan of 140 mg/m2 (due to renal failure) as conditioning regimen. Second transplant conditioning was melphalan of 200 mg/m2 for one patient and melphalan of 140 mg/m2 for remaining four patients. Two patients were in complete remission, and two were in very good partial remission and one patient progressed to active disease at the time of tandem autologous bone marrow transplant. All patients developed significant mucositis. Neutrophil and platelet recovery was longer in tandem autologous hematopoietic stem cell transplant. More viral infections were seen in tandem transplant. Day 30 and day 100 mortality was nil. Conclusion We present data on tandem autologous HSCTs in very young patients with MM in India. Responses continued to improve in this small series.

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Effects of double-dose statin therapy for the prevention of post-stroke epilepsy: A prospective clinical study

Seizure ◽

10.1016/j.seizure.2021.04.010 ◽

2021 ◽

Author(s):

Yanmei Zhu ◽

Haiyan Gou ◽

Long Ma ◽

Jiahang Sun ◽

Yuting Hou ◽

...

Keyword(s):

Clinical Study ◽

Statin Therapy ◽

Prospective Clinical Study ◽

Double Dose ◽

Post Stroke

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Phase I dose-finding, safety and tolerability trial of Romiplostim to Improve Platelet Recovery after UCB Transplantation

Transplantation and Cellular Therapy ◽

10.1016/j.jtct.2021.02.033 ◽

2021 ◽

Author(s):

Georgios E. Christakopoulos ◽

Todd E. DeFor ◽

Stefanie Hage ◽

John E. Wagner ◽

Michael A. Linden ◽

...

Keyword(s):

Phase I ◽

Dose Finding ◽

Platelet Recovery

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Mathematical analysis of a measles transmission dynamics model in Bangladesh with double dose vaccination

Scientific Reports ◽

10.1038/s41598-021-95913-8 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Md Abdul Kuddus ◽

M. Mohiuddin ◽

Azizur Rahman

Keyword(s):

Basic Reproduction Number ◽

Reproduction Number ◽

Transmission Rate ◽

Equilibrium Points ◽

Rank Correlation ◽

Dynamical Analysis ◽

Model Parameters ◽

Progression Rate ◽

Double Dose ◽

The Basic Reproduction Number

AbstractAlthough the availability of the measles vaccine, it is still epidemic in many countries globally, including Bangladesh. Eradication of measles needs to keep the basic reproduction number less than one $$(\mathrm{i}.\mathrm{e}. \, \, {\mathrm{R}}_{0}<1)$$ ( i . e . R 0 < 1 ) . This paper investigates a modified (SVEIR) measles compartmental model with double dose vaccination in Bangladesh to simulate the measles prevalence. We perform a dynamical analysis of the resulting system and find that the model contains two equilibrium points: a disease-free equilibrium and an endemic equilibrium. The disease will be died out if the basic reproduction number is less than one $$(\mathrm{i}.\mathrm{e}. \, \, {\mathrm{ R}}_{0}<1)$$ ( i . e . R 0 < 1 ) , and if greater than one $$(\mathrm{i}.\mathrm{e}. \, \, {\mathrm{R}}_{0}>1)$$ ( i . e . R 0 > 1 ) epidemic occurs. While using the Routh-Hurwitz criteria, the equilibria are found to be locally asymptotically stable under the former condition on $${\mathrm{R}}_{0}$$ R 0 . The partial rank correlation coefficients (PRCCs), a global sensitivity analysis method is used to compute $${\mathrm{R}}_{0}$$ R 0 and measles prevalence $$\left({\mathrm{I}}^{*}\right)$$ I ∗ with respect to the estimated and fitted model parameters. We found that the transmission rate $$(\upbeta )$$ ( β ) had the most significant influence on measles prevalence. Numerical simulations were carried out to commissions our analytical outcomes. These findings show that how progression rate, transmission rate and double dose vaccination rate affect the dynamics of measles prevalence. The information that we generate from this study may help government and public health professionals in making strategies to deal with the omissions of a measles outbreak and thus control and prevent an epidemic in Bangladesh.

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Outcomes of Adolescents and Young Adults Compared with Children with Acute Leukemia after Single-Unit Unrelated Cord Blood Transplantation Using Myeloablative Conditioning without Antithymocyte Globulin

Acta Haematologica ◽

10.1159/000507973 ◽

2021 ◽

pp. 1-11

Author(s):

Xuhan Zhang ◽

Huilan Liu ◽

Changcheng Zheng ◽

Baolin Tang ◽

Xiaoyu Zhu ◽

...

Keyword(s):

Acute Leukemia ◽

Single Unit ◽

Antithymocyte Globulin ◽

Immune Reconstitution ◽

Cord Blood Transplantation ◽

Myeloablative Conditioning ◽

Platelet Recovery ◽

Blood Transplantation ◽

Cell Counts ◽

Neutrophil Engraftment

Background: Although the use of cord blood transplantation (CBT) is becoming more frequent in acute leukemia, considering the relationship between the low stem cell dose and graft failure, whether use of CBT for adolescents and young adults (AYAs) is appropriate remains uncertain. Methods: A retrospective registry-based analysis of clinical outcomes and immune reconstitution was conducted for 105 AYAs and 187 children with acute leukemia who underwent single-unit CBT using myeloablative conditioning (MAC) without antithymocyte globulin (ATG). Results: Outcomes were similar between AYAs and children, except for nonrelapse mortality (NRM) and recovery rates of neutrophils and platelets. The 30-day cumulative incidence of neutrophil engraftment was similar between AYAs and children, but children had faster rates of neutrophil and platelet recovery than AYAs. The median time to neutrophil engraftment was earlier in children than in AYAs (AYAs, 19 days, 95% confidence interval [CI] 17.3–21.7; children, 16 days, 95% CI 13.1–19.5, p = 0.00003). The incidence of platelet recovery on day 120 was higher in children than in AYAs (AYAs, 80%, 95% CI 71–81%; children, 88%, 95% CI 82–92%, p = 0.037). CD34+ cell dose was the only independent factor influencing both neutrophil and platelet recovery. The cumulative incidence of NRM at 2 years was higher among AYAs than among children (AYAs, 27.5%, 95% CI 20–37%; children, 15%, 95% CI 10–21%, p = 0.008). Conditioning regimen was an independent factor influencing NRM. With respect to immune reconstitution, natural killer cell counts quickly recovered to normal levels 1-month post-CBT in both children and AYAs. CD8+ T-cell counts were higher in children than in AYAs at 1 and 3 months post-CBT. CD4+ T-cell counts were similar in both children and AYAs after CBT. Conclusion: AYAs with acute leukemia have outcomes of single-unit CBT using MAC without ATG that are as good as those of children. Thus, single-unit CBT using modified MAC without ATG is an acceptable choice for both AYAs and children who do not have a suitable donor.

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Phase II Trial of Vorinostat With Idarubicin and Cytarabine for Patients With Newly Diagnosed Acute Myelogenous Leukemia or Myelodysplastic Syndrome

Journal of Clinical Oncology ◽

10.1200/jco.2011.38.3265 ◽

2012 ◽

Vol 30 (18) ◽

pp. 2204-2210 ◽

Cited By ~ 110

Author(s):

Guillermo Garcia-Manero ◽

Francesco Paolo Tambaro ◽

Nebiyou B. Bekele ◽

Hui Yang ◽

Farhad Ravandi ◽

...

Keyword(s):

Myelodysplastic Syndrome ◽

Acute Myelogenous Leukemia ◽

Single Agent ◽

Complete Response ◽

Myelogenous Leukemia ◽

Platelet Recovery ◽

Free Survival ◽

Binding Factor ◽

Deacetylase Inhibitor ◽

Acute Myelogenous

Purpose To evaluate the safety and efficacy of the combination of the histone deacetylase inhibitor vorinostat with idarubicin and ara-C (cytarabine) in patients with acute myelogenous leukemia (AML) or myelodysplastic syndrome (MDS). Patients and Methods Patients with previously untreated AML or higher-risk MDS age 15 to 65 years with appropriate organ function and no core-binding factor abnormality were candidates. Induction therapy was vorinostat 500 mg orally three times a day (days 1 to 3), idarubin 12 mg/m2 intravenously (IV) daily × 3 (days 4 to 6), and cytarabine 1.5 g/m2 IV as a continuous infusion daily for 3 or 4 days (days 4 to 7). Patients in remission could be treated with five cycles of consolidation therapy and up to 12 months of maintenance therapy with single-agent vorinostat. The study was designed to stop early if either excess toxicity or low probability of median event-free survival (EFS) of more than 28 weeks was likely. Results After a three-patient run-in phase, 75 patients were treated. Median age was 52 years (range, 19 to 65 years), 29 patients (39%) were cytogenetically normal, and 11 (15%) had FLT-3 internal tandem duplication (ITD). No excess vorinostat-related toxicity was observed. Induction mortality was 4%. EFS was 47 weeks (range, 3 to 134 weeks), and overall survival was 82 weeks (range, 3 to 134 weeks). Overall response rate (ORR) was 85%, including 76% complete response (CR) and 9% in CR with incomplete platelet recovery. ORR was 93% in diploid patients and 100% in FLT-3 ITD patients. Levels of NRF2 and CYBB were associated with longer survival. Conclusion The combination of vorinostat with idarubicin and cytarabine is safe and active in AML.

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A deadly double dose for India’s poor

Nature Sustainability ◽

10.1038/s41893-021-00752-0 ◽

2021 ◽

Author(s):

Zoë Chafe ◽

Sourangsu Chowdhury

Keyword(s):

Double Dose

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The growing practice of “splitting” double-dose apheresis platelet products

Transfusion Science ◽

10.1016/s0955-3886(05)80008-6 ◽

1993 ◽

Vol 14 (4) ◽

pp. 364-368 ◽

Cited By ~ 4

Author(s):

Frederick B. Axelrod

Keyword(s):

Double Dose

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Correlation of a missense mutation in the human Secretorα1,2-fucosyltransferase gene with the Lewis(a+b+) phenotype: a potential molecular basis for the weak Secretor allele (Sew)

Biochemical Journal ◽

10.1042/bj3120329 ◽

1995 ◽

Vol 312 (2) ◽

pp. 329-332 ◽

Cited By ~ 41

Author(s):

L C Yu ◽

Y H Yang ◽

R E Broadberry ◽

Y H Chen ◽

Y S Chan ◽

...

Keyword(s):

Missense Mutation ◽

Molecular Basis ◽

Double Dose ◽

Fucosyltransferase Gene ◽

Lewis A

A missense mutation (A385 to T), predicting an Ile129 to Phe substitution, in the human Secretor alpha 1,2-fucosyltransferase gene was present in double dose in Lewis(a+b+) individuals, but not in Lewis(a-b+) individuals. Co-segregation of the Lewis(a+b+) phenotype with homozygosity for the mutation was also verified. These results yield a potential molecular basis for the weak Secretor allele (Sew) accounting for the Lewis(a+b+) phenotype.

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