Mannose-binding lectin level and deficiency is not associated with inflammatory bowel diseases, disease phenotype, serology profile, and NOD2/CARD15 genotype in a large Hungarian cohort

Abstract Background It is unclear whether inflammatory bowel diseases (IBD) affect the phenotype and severity of co-occurring axial spondyloarthropathies (axSpA) and psoriasis. Therefore, we aimed to investigate the characteristics of axSpA and psoriasis in relation to co-occurring IBD. Methods The systematic review and meta-analysis were conducted according to Cochrane’s recommendations. PubMed and EMBASE were searched from database inception till January 2020 for studies reporting disease phenotype and severity of axSpA and psoriasis in association with co-occurrence of IBD. Meta-analyses were performed using a random-effects model. Quality of the studies was assessed by the Newcastle-Ottawa Scale (NOS). Results The electronic search yielded 12,220 studies which were narrowed down to 152 after screening based on study titles and abstracts. Of these, a full-text review identified 20 eligible studies, including twelve and eight studies describing characteristics of axSpA and psoriasis, respectively, in relation to IBD. AxSpA was identified among a total of 321 and 8,660 patients with and without a co-occurring IBD, respectively, and the studies’ mean NOS score was 6.8, including seven and five studies of moderate and high quality, respectively. The meta-analysis demonstrated that presence of co-occurring IBD was associated with an increased risk of dactylitis (risk ratio (RR)=2.06 (95%CI 1.24–3.42), I2=0%), but not enthesitis (RR=0.93 (95%CI 0.48–1.81), I2=86%). Furthermore, IBD was associated with a significantly lower Bath Ankylosing Spondylitis Radiology Index (mean difference (meandiff) -2.28 (95%CI -3.26-(-1.30)), p<0.01, I2=0%), better Schober’s test results (meandiff 0.80 (95%CI 0.64–1.49), p<0.01, I2=0%), and a lower finger to floor distance (meandiff -6.36 (95%CI -10.36-(-2.36)), p<0.01, I2=0%). The phenotype of psoriasis was assessed among 680 and 222,279 patients with and without a co-occurring IBD. The mean NOS score was 7.4, including two studies of moderate methodological quality, while the remaining six studies were of high quality. The presence of IBD was associated with a significantly less frequent presentation of psoriasis in the nails (RR=0.14 (95%CI 0.05–0.42), I2=0%) but not psoriatic arthritis (RR=0.94 (95%CI 0.27–3.31), I2=75%). Finally, the presence of IBD was associated with a milder phenotype of psoriasis (RR=1.41 (95%CI 1.02–1.96), p=0.04, I2=70%). Conclusion This is the first systematic review with meta-analysis investigating the impact of IBD on the disease phenotype and severity of psoriasis and axSpA. Our data suggest that IBD modifies psoriasis and axSpA to be milder and emphasizes the importance of a multidisciplinary approach to patients with psoriasis or axSpA and co-occurring IBD.

Download Full-text

P748 Characteristics of inflammatory bowel diseases in different stage of adolescence

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jjz203.876 ◽

2020 ◽

Vol 14 (Supplement_1) ◽

pp. S599-S599

Author(s):

K J Szántó ◽

A Bálint ◽

R Bor ◽

A Fábián ◽

Á Milassin ◽

...

Keyword(s):

Inflammatory Bowel Diseases ◽

Hospital Admissions ◽

Insurance Fund ◽

Prevalence Rates ◽

Disease Phenotype ◽

Late Adolescent ◽

Observational Period ◽

Adolescent Patients ◽

Bowel Diseases ◽

Inflammatory Bowel

Abstract Background There is a lack of data regarding clinical and therapeutic characteristics in middle and late adolescent inflammatory bowel diseases (IBD) patients in real life. Our aim was to retrospectively evaluate patient’s characteristics and therapeutic features among the Hungarian adolescent inflammatory bowel diseases population. Also our aim was to assess whether these patients before the transition have more serious disease phenotype than those after transition. Methods Retrospective, epidemiological study using the National Health Insurance Fund social security databases. Adolescent Hungarian IBD patients who were observable in the database between 2008 and 2017 were enrolled. Patients were analysed according to two groups: patients between ages of 14–17 years were defined middle adolescent patients, and patients between 18–21 years were defined late adolescent patients. Results The incidence of IBD was 24.82/100 000 in the middle and 38.17/100 000 in the late adolescent patients. Prevalence rates showed an increasing tendency in both groups. Incidence and prevalence rates were higher in the late adolescent patients. Mesalazine was used in high proportion of patients (66.6% vs. 69.3% of the middle and late adolescent patients, respectively), also in UC and CD patients. While, the use of sulphasalazine (13.1% vs. 19.6%, respectively) and azathioprine (20.3% vs. 11%, respectively) was relatively low. The need of biologics was higher in the middle adolescence group (p < 0.001). Use of anti-TNF agents increased during the observational period in both groups (p < 0.001). Corticosteroid use was similar in both groups; a decreasing tendency was observed. Rate of hospital admissions to gastroenterology department was higher than to surgery department in both groups. The number of hospital admissions to gastroenterology (p < 0.001, p = 0.001) and surgery departments (p < 0.001 and p = 0.031) decreased significantly in both groups throughout the observational period. Conclusion We have analysed the data of huge number of adolescent patients diagnosed with IBD to get better overview on the clinical and treatment characteristics of patients in these sensitive age groups. Overall, the increasing use of anti-TNF therapy and decreasing tendency of corticosteroid use reflects significant changes and improvement in treatment paradigm not only in adult but paediatric care. The higher need of anti-TNF agents reflects that these adolescent patients before the transition have more severe disease phenotype.

Download Full-text

Mannose-binding lectin (MBL) in adult patients with inflammatory bowel disease

Immunobiology ◽

10.1016/j.imbio.2019.10.008 ◽

2020 ◽

Vol 225 (1) ◽

pp. 151859 ◽

Cited By ~ 1

Author(s):

Leokadia Bąk-Romaniszyn ◽

Anna S. Świerzko ◽

Anna Sokołowska ◽

Łukasz Durko ◽

Grażyna Mierzwa ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Mannose Binding Lectin ◽

Adult Patients ◽

Mannose Binding ◽

Inflammatory Bowel ◽

Binding Lectin

Download Full-text

ATP-binding cassette transporter ABCG2 (BCRP) and ABCB1 (MDR1) variants are not associated with disease susceptibility, disease phenotype response to medical therapy or need for surgeryin Hungarian patients with inflammatory bowel diseases

Scandinavian Journal of Gastroenterology ◽

10.1080/00365520601101559 ◽

2007 ◽

Vol 42 (6) ◽

pp. 726-733 ◽

Cited By ~ 25

Author(s):

Simon Fischer ◽

Peter Laszlo Lakatos ◽

AND THE HUNGARIAN IBD STUDY GROUP ◽

Laszlo Lakatos ◽

Agota Kovacs ◽

...

Keyword(s):

Medical Therapy ◽

Inflammatory Bowel Diseases ◽

Disease Susceptibility ◽

Atp Binding ◽

Disease Phenotype ◽

Atp Binding Cassette Transporter ◽

Bowel Diseases ◽

Inflammatory Bowel ◽

Atp Binding Cassette

Download Full-text

Polymorphisms in the Mannose-Binding Lectin Gene are Associated with Defective Mannose-Binding Lectin Functional Activity in Crohn’s Disease Patients

Scientific Reports ◽

10.1038/srep29636 ◽

2016 ◽

Vol 6 (1) ◽

Cited By ~ 3

Author(s):

Laura Choteau ◽

Francis Vasseur ◽

Frederic Lepretre ◽

Martin Figeac ◽

Corine Gower-Rousseau ◽

...

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Functional Activity ◽

Serine Proteases ◽

Mannose Binding Lectin ◽

Lectin Pathway ◽

Disease Phenotype ◽

Mannose Binding ◽

Antibody Levels ◽

Binding Lectin

Abstract Mannose-binding lectin, together with mannose-associated serine proteases, activates the lectin pathway of the complement system and subsequent inflammatory mechanisms. An association between mannose-binding lectin deficiency and anti-Saccharomyces cerevisiae antibody levels is observed in Crohn’s disease and this deficiency is frequently associated with a severe Crohn’s disease phenotype. In the present study, we assessed the relationship between serum concentrations of mannose-binding lectin, mannose-binding lectin functional activity, MBL2 and NOD2 polymorphisms, anti-S. cerevisiae antibody levels and clinical Crohn’s disease phenotype in 69 Crohn’s disease patients and 30 age- and sex-matched healthy controls. The results show that the MBL2 variant rs5030737 at codon 52 was associated with a low level of mannose-binding lectin and impaired mannose-binding lectin–mannose-associated serine protease (MBL-MASP) functional activity in Crohn’s disease patients. This MBL2 variant was also associated with a higher level of anti-S. cerevisiae antibodies. In addition, the NOD2 variant rs2066844, which is associated with susceptibility to Crohn’s disease, was significantly correlated with an impairment in MBL-MASP functional activity. These results provide evidence that Crohn’s disease patients have an impairment in MBL-MASP functional activity and that this defect is associated with MBL2 and NOD2 variants.

Download Full-text