scholarly journals SCD-A-112 attenuates scopolamine-induced learning and memory impairments in mice by improving cholinergic transmission via activation of CREB/NGF signaling

IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S207
Author(s):  
Eunjin Sohn ◽  
Hye-Sun Lim ◽  
Yu Jin Kim ◽  
Bu-Yeo Kim ◽  
Joo Hwan Kim ◽  
...  
Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1205 ◽  
Author(s):  
Eunjin Sohn ◽  
Hye-Sun Lim ◽  
Yu Jin Kim ◽  
Bu-Yeo Kim ◽  
Joo-Hwan Kim ◽  
...  

We aimed to investigate the therapeutic effects of an Elaeagnus glabra f. oxyphylla (EGFO) ethanol extract in mice with scopolamine-induced memory dysfunction. Fifty male mice were randomly divided into a normal control group, a scopolamine-treated group, a scopolamine and EGFO extract-treated group, and a scopolamine and tacrine-treated group. EGFO (50 or 100 mg/kg/day) was received for 21 days. Step-through passive avoidance and Y-maze tests were performed to examine the effects of treatment on learning and memory impairments. Acetylcholine (Ach) levels and acetylcholinesterase (AchE) activity were measured via an enzyme-linked immunosorbent assay (ELISA). Levels of choline acetyltransferase (ChAT), nerve growth factor (NGF), cAMP response element-binding protein (CREB), and apoptosis-related protein expression were determined via Western blot analysis. EGFO pretreatment significantly attenuated scopolamine-induced memory impairments, relative to findings observed in the scopolamine-treated group. Levels of cholinergic factors in the brain tissues were markedly attenuated in the scopolamine-treated group. EGFO treatment also attenuated neural apoptosis in scopolamine-treated mice by decreasing the expression of apoptosis-related proteins such as Bax, Bcl2, cleaved caspase-3, and TUNEL staining. These results suggest that EGFO improves memory and cognition in a mouse model of memory impairment by restoring cholinergic and anti-apoptotic activity, possibly via activation of CREB/NGF signaling.


2014 ◽  
Vol 272 (1-2) ◽  
pp. 35-41 ◽  
Author(s):  
Tatiana Barichello ◽  
Valdemira S. Dagostim ◽  
Jaqueline S. Generoso ◽  
Lutiana R. Simões ◽  
Diogo Dominguini ◽  
...  

2008 ◽  
Vol 594 (1-3) ◽  
pp. 93-100 ◽  
Author(s):  
Heng Yan Qu ◽  
Ting Zhang ◽  
Xu Ling Li ◽  
Jian Ping Zhou ◽  
Bao Quan Zhao ◽  
...  

2019 ◽  
Vol 842 ◽  
pp. 365-372 ◽  
Author(s):  
Bosai He ◽  
Fanxing Xu ◽  
Tingxu Yan ◽  
Feng Xiao ◽  
Bo Wu ◽  
...  

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