Bioactivity and biocompatibility of a chitosan-tobermorite composite membrane for guided tissue regeneration

Author(s):  
A.P. Hurt ◽  
G. Getti ◽  
N.J. Coleman
2009 ◽  
Vol 112 (5) ◽  
pp. 3127-3134 ◽  
Author(s):  
Shyh Ming Kuo ◽  
Shwu Jen Chang ◽  
Gregory Cheng-Chie Niu ◽  
Cheng-Wen Lan ◽  
Wen Tai Cheng ◽  
...  

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Jian-Wen Wang ◽  
Min-Hsiung Hon ◽  
Yi-Ming Kuo ◽  
Mei-Hui Chung

A novel composite membrane ofβ-tricalcium pyrophosphate (β-TCP) and fructose- (F-) mediated chitosan/poly(ethylene glycol) (CS/PEG) was prepared by thermally induced phase separation technique. The prepared composite membranes were characterized using scanning electron microscopy (SEM) and X-ray diffraction (XRD). The mechanical property, swelling, degradation, and cytotoxicity of the composite membranes were evaluated in vitro with respect to its potential for use as biodegradable guided tissue regeneration (GTR) membrane. In vitro degradation tests showed the composite membrane with a controllable degradation rate when changing theβ-TCP content. The incorporation ofβ-TCP granules also caused a significant enhancement of tensile strength. Whenβ-TCP content is controlled to 50 wt%, homogeneous composite membranes with well mechanical property and enzymatic degradation rate can be obtained. Cytotoxicity assay demonstrates that the composite membranes were nontoxic and had very good cell compatibility. Most importantly, the release of calcium ions and glucosamine from the composite membranes was proved to increase the cell proliferation of NIH3T3. The results of this study have indicated that this novel F-β-TCP/CS/PEG composite can be a suitable material for GTR applications.


Biomaterials ◽  
2005 ◽  
Vol 26 (36) ◽  
pp. 7564-7571 ◽  
Author(s):  
Susan Liao ◽  
Wei Wang ◽  
Motohiro Uo ◽  
Shoji Ohkawa ◽  
Tsukasa Akasaka ◽  
...  

2018 ◽  
Author(s):  
Murtaza Kaderi ◽  
Mohsin Ali ◽  
Alfiya Ali ◽  
Tasneem Kaderi

The goals of periodontal therapy are to arrest of periodontal disease progression and to attain the regeneration of the periodontal apparatus. Osseous grafting and Guided tissue regeneration (GTR) are the two techniques with the most extensive documentation of periodontal regeneration. However, these techniques offer limited potential towards regenerating the periodontal tissues. Recent surgical procedures and application of newer materials aim at greater and more predictable regeneration with the concept of tissue engineering for enhanced periodontal regeneration and functional attachment have been developed, analyzed, and employed in clinical practice


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