Functional characteristics improvement by structural modification of hydroxypropyl methylcellulose modified polyvinyl alcohol films incorporating roselle anthocyanins for shrimp freshness monitoring

Aim: Self-healing, swellable and biodegradable polymers are vital materials that may facilitate the different stages of wound healing. The aim of this research was to prepare wound healing films using self-healing polyvinyl alcohol (PVA), swellable hydroxypropyl methylcellulose (HPMC), biodegradable polyglycolic acid (PGA) sutures and ciprofloxacin antibiotic for improved treatment outcome. Methods: Films were formulated through aqueous-based mixing of varying amounts of polyvinyl alcohol (10–20% weight/weight (w/w)) and hydroxypropyl methylcellulose (0.5, 1% w/w) with fixed quantities of ciprofloxacin. PGA sutures were placed as grids within the wet mixtures of the polymers and ciprofloxacin, and thereafter products were air dried. The formulated films were evaluated for swelling ratio, breaking elongation, folding endurance, moisture uptake and loss, compatibility and in vitro antibiotic release. Furthermore, in vivo wound healing was studied using excision model and histopathological examinations. Results: Swelling ratios were above 1.0 and the films were minimally stretchable, with folding endurance greater than 500. Films were stable while moisture uptake and loss were observed to be less than 30%. Among the optimised hydrogel batches, those containing 10% w/w PVA and 1% w/w HPMC with no PGA showed the highest drug release of 73%, whereas the batches with higher PGA content showed higher percentage wound size reduction with minimal scar. The completeness of wound healing with batches containing PVA, HPMC, ciprofloxacin and PGA, along with the standard, is evident considering the massive cornification, regeneration of the epithelial front and stratum spinosum. Conclusion: The findings show that polymer-based multifunctional composite films are suitable for use as dressings for improved wound healing.

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Accelerated Stability Testing of a Polyherbal Transdermal Patches Using Polyvinyl Alcohol and Hydroxypropyl Methylcellulose as a Controlling Polymer Layer

Journal of Polymers and the Environment ◽

10.1007/s10924-018-1280-x ◽

2018 ◽

Vol 26 (10) ◽

pp. 4056-4062

Author(s):

Jirapornchai Suksaeree ◽

Chomnapas Chuchote

Keyword(s):

Polyvinyl Alcohol ◽

Hydroxypropyl Methylcellulose ◽

Polymer Layer ◽

Stability Testing ◽

Transdermal Patches ◽

Accelerated Stability

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THE USE OF HUMIC ACIDS FOR MODIFICATION OF BIODEGRADABLE FILMS MANUFACTURED ON THE BASIS OF POLYVINYL ALCOHOL AND HYDROXYPROPYLMETHYL CELLULOSE

Journal of Coal Chemistry ◽

10.31081/1681-309x-2021-0-6-22-37 ◽

2021 ◽

Vol 6 ◽

pp. 22-37

Author(s):

Zhang Siaobin ◽

V.V Lebedev ◽

D.V Miroshnichenko

Keyword(s):

Polyvinyl Alcohol ◽

Mathematical Models ◽

Humic Substances ◽

Structure Formation ◽

Humic Acids ◽

Polymer Films ◽

Biodegradable Polymer ◽

Hydroxypropyl Methylcellulose ◽

Specific Effect ◽

Low Grade

The article is devoted to the problem of obtaining packaging materials that combine a high level of gas and / or moisture resistance and strength with the ability to quickly decompose without harmful effects on the environment. The purpose of the research described in the article is to study the possibility of making such a material, which, during the period of use, will not only be resistant to the effects of various bacteria, but even prevent their appearance, and upon burial it will be biodegradable. The initial components, namely polyvinyl alcohol, hydroxypropyl methylcellulose, and humic acids of coal origin (as antibacterial additives) were reasonably selected. The modifying effect of humic substances obtained from three different samples of low-grade Ukrainian coal has been studied. In the course of the studies performed, it was found that humic acids of different origins and with different characteristics have a specific effect on the processes of structure formation in solutions of polyvinyl alcohol and hydroxypropyl methylcellulose. In particular, it was shown that in polyvinyl alcohol and methylcellulose solutions with the addition of humic acids that do not contain particles of carbon residues of various degrees of dispersion, an increase in the formation of an ordered structure is observed. Micrographs of solutions of polyvinyl alcohol and hydroxypropyl methylcellulose with humic acids are presented. The peculiarities of the influence of humic substances on the processes of structure formation of solutions of polyvinyl alcohol and hydroxypropyl methylcellulose have been investigated in order to obtain hybrid environmentally friendly biodegradable polymer films. The corresponding experimental-statistical mathematical models have been developed, they describe the dependence of the conditional viscosity and conductivity of polyvinyl alcohol and hydroxypropyl methylcellulose on the content of humic acids, the duration of preparation and one of the characteristics of the raw materials used to obtain humic acids. The corresponding equations are given. Keywords: biodegradable polymer films, coal, humic acids, polyvinyl alcohol, hydroxypropyl methylcellulose, experimental statistical mathematical models Corresponding author Zhang Siaobin, e-mail: [email protected]

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Photoselection of Luminescent Molecules in Anisotropic Media in the Case of Two-Photon Excitation. Part II. Experimental Studies of Hoechst 33342 in Stretched Polyvinyl alcohol) Films

Zeitschrift für Naturforschung A ◽

10.1515/zna-1996-0910 ◽

1996 ◽

Vol 51 (9) ◽

pp. 1037-1041 ◽

Cited By ~ 6

Author(s):

A. Kawski ◽

Z. Gryczyński ◽

I. Gryczyński ◽

J. R. Lakowicz ◽

G. Piszczek

Keyword(s):

Polyvinyl Alcohol ◽

Vinyl Alcohol ◽

Experimental Studies ◽

Poly Vinyl Alcohol ◽

Hoechst 33342 ◽

Emission Anisotropy ◽

Two Photon ◽

Photon Excitation ◽

Polyvinyl Alcohol Films ◽

Two Photon Excitation

Abstract It was found by investigating dichroism and emission anisotropy in the case of one-and two-photon excitation of Hoechst 33342 [bis-benzimide,2,5'-bi-1H-benzimidazole, 2'-(4-ethoxyphenyl)-5-5(4-methyl-1-piperazinyl)] in stretched poly(vinyl alcohol) (PVA) films, that the absorption and fluorescence transition moments lie along the long molecular axis of the molecule studied. The slight deviation of the transition moment direction in fluorescence (about 8°) from that in absorption can be due to the incomplete linearity of the Hoechst molecule.

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