Cardiovascular pharmacotherapy and herbal medicines: the risk of drug interaction

2005 ◽  
Vol 98 (1) ◽  
pp. 1-14 ◽  
Author(s):  
Angelo A. Izzo ◽  
Giulia Di Carlo ◽  
Francesca Borrelli ◽  
Edzard Ernst
Keyword(s):  
Drug Interaction ◽  
Herbal Medicines ◽  
Cardiovascular Pharmacotherapy

Herbal Drug Interactions

2017 ◽  
pp. 201-231 ◽  
Author(s):  
Mymoona Akhter
Keyword(s):  
Drug Interaction ◽  
Side Effects ◽  
Adverse Effects ◽  
Drug Interactions ◽  
Herbal Medicines ◽  
Herbal Drugs ◽  
Herbal Drug ◽  
Herbal Therapy ◽  
Alternative Medicines ◽  
Regulatory Bodies

Use of complementary and alternative medicines (CAM) for preventive and therapeutic purposes has increased tremendously in the last two decades internationally. The manufacturers of these products are not required to submit proof of safety or efficacy to the Food and Drug Administration. As a result, the adverse effects and drug interactions associated with them are largely unknown. In this chapter, the author presents interactions of herbal medicines with other medicines (herbal or non-herbal). A large number of herbal drugs, including from single drug to a variety of mixtures have been used to treat kidney disorders. Herb-herb or herb drug interaction has been reported intensively during last decade, therefore it becomes important to keep an eye on the use of combination herbal therapy in order to avoid serious results because of interactions with each other. Due to the growing awareness about the interactions and side effects of herbal drugs/supplements over the past few years, regulatory bodies are working on these issues and pharmacopoeias are being developed for reference.

Herbal Drug Interactions

2022 ◽  
pp. 120-141
Author(s):  
Mymoona Akhter
Keyword(s):  
Drug Interaction ◽  
Side Effects ◽  
Adverse Effects ◽  
Drug Interactions ◽  
Herbal Medicines ◽  
Herbal Drugs ◽  
Herbal Drug ◽  
Herbal Therapy ◽  
Alternative Medicines ◽  
Regulatory Bodies

Use of complementary and alternative medicines (CAM) for preventive and therapeutic purposes has increased tremendously in the last two decades internationally. The manufacturers of these products are not required to submit proof of safety or efficacy to the Food and Drug Administration. As a result, the adverse effects and drug interactions associated with them are largely unknown. In this chapter, the author presents interactions of herbal medicines with other medicines (herbal or non-herbal). A large number of herbal drugs, including from single drug to a variety of mixtures have been used to treat kidney disorders. Herb-herb or herb drug interaction has been reported intensively during last decade, therefore it becomes important to keep an eye on the use of combination herbal therapy in order to avoid serious results because of interactions with each other. Due to the growing awareness about the interactions and side effects of herbal drugs/supplements over the past few years, regulatory bodies are working on these issues and pharmacopoeias are being developed for reference.

scholarly journals Drug Interaction Between Complementary Herbal Medicines and Gefitinib

2008 ◽  
Vol 3 (8) ◽  
pp. 942-943 ◽  
Author(s):  
Sung-Wook Hwang ◽  
Hye-Suk Han ◽  
Kun Young Lim ◽  
Ji-Youn Han
Keyword(s):  
Drug Interaction ◽  
Herbal Medicines

scholarly journals Pharmacogenomics and Herb-Drug Interactions: Merge of Future and Tradition

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Mou-Ze Liu ◽  
Yue-Li Zhang ◽  
Mei-Zi Zeng ◽  
Fa-Zhong He ◽  
Zhi-Ying Luo ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Drug Interactions ◽  
Genetic Factors ◽  
Herbal Medicines ◽  
Interaction Effects ◽  
Genetic Variations ◽  
The Other ◽  
Previous Review ◽  
Metabolism Enzymes ◽  
Underlying Mechanisms

The worldwide using of herb products and the increasing potential herb-drug interaction issue has raised enthusiasm on discovering the underlying mechanisms. Previous review indicated that the interactions may be mediated by metabolism enzymes and transporters in pharmacokinetic pathways. On the other hand, an increasing number of studies found that genetic variations showed some influence on herb-drug interaction effects whereas these genetic factors did not draw much attention in history. We highlight that pharmacogenomics may involve the pharmacokinetic or pharmacodynamic pathways to affect herb-drug interaction. We are here to make an updated review focused on some common herb-drug interactions in association with genetic variations, with the aim to help safe use of herbal medicines in different individuals in the clinic.

scholarly journals Influence Factors of the Pharmacokinetics of Herbal Resourced Compounds in Clinical Practice

2019 ◽  
Vol 2019 ◽  
pp. 1-16 ◽  
Author(s):  
Shi Sun ◽  
Yifang Wang ◽  
Ailing Wu ◽  
Zhen Ding ◽  
Xinguang Liu
Keyword(s):  
Drug Interaction ◽  
Clinical Practice ◽  
Influence Factors ◽  
Herbal Medicines ◽  
The Body ◽  
Drug Metabolizing Enzymes ◽  
The West ◽  
Metabolizing Enzymes ◽  
Potential Factors ◽  
Clinical Risks

Herbal medicines have been used to prevent and cure diseases in eastern countries for thousands of years. In recent decades, these phytotherapies are becoming more and more popular in the West. As being nature-derived is the essential attribute of herbal medicines, people believe that taking them for diseases treatment is safe enough and has no side-effects. However, the efficacy of herbal resourced compounds (HRC) depends on the multiple constituents absorbed in the body and their pharmacokinetics. Thus, many factors will influence the clinical practice of HRC, i.e., their absorption, distribution, metabolism, and excretion (ADME). Among these factors, herb-drug interaction has been widely discussed, as these compounds may share the same drug-metabolizing enzymes and drug transporters. Meanwhile there are many other potential factors that can also change the ADME of HRC, including herb pretreatment, herb-herb interactions, pathological status, gender, age of patient, and chemical and physical modification of certain ingredients. With the aim of ensuring the efficacy of HRC and minimizing their clinical risks, this review provides and discusses the influence factors and artificial improvement of the pharmacokinetics of HRC.

scholarly journals Isolation of CYP3A4 Inhibitors from the Black Cohosh (Cimicifuga racemosa)

2005 ◽  
Vol 2 (2) ◽  
pp. 223-226 ◽  
Author(s):  
Sachiko Tsukamoto ◽  
Maki Aburatani ◽  
Tomihisa Ohta
Keyword(s):  
Drug Interaction ◽  
Dietary Supplement ◽  
Intestinal Epithelium ◽  
Herbal Medicines ◽  
Black Cohosh ◽  
Cimicifuga Racemosa ◽  
Cyp3a4 Inhibition ◽  
Cyp3a4 Inhibitors ◽  
Post Menopausal ◽  
Oral Availability

Recent investigation on drug interaction has shown that some foods and herbal medicines increase the oral availability of a variety of CYP3A4 substrates, which is caused by the reduction of CYP3A4 in intestinal epithelium. During the course of our investigation on CYP3A4 interaction, we found that the commercially available dietary supplement made from black cohosh (Cimicifuga racemosa) showed CYP3A4 inhibition. Black cohosh has been used for the treatment of menopausal and post-menopausal symptoms as a dietary supplement. Bioassay-guided isolation from the supplement afforded six active principles, which were identified as cycloartanoid triterpene glycosides.

scholarly journals Evaluation for the level of knowledge about herbal medicine use within people and university students in Mutah region

Pharmacia ◽  
2020 ◽  
Vol 67 (4) ◽  
pp. 397-403
Author(s):  
Afaf H. Al-Nadaf ◽  
Areeg Awadallah
Keyword(s):  
Drug Interaction ◽  
Herbal Medicine ◽  
Folk Medicine ◽  
Herbal Medicines ◽  
Medicine Use ◽  
Self Medication ◽  
Traditional Medicines ◽  
The Public ◽  
Care Givers ◽  
Knowledge And Attitude

Background: Conventional medication; traditional or folk medicine as well as herbal medicines; have been widely used since ancient times. In Jordan traditional medicines are freely available and self-prescribed as well. No previous study has investigated believes and knowledge with regards to herb-drug interaction in Mutah geographical in Jordan. Objectives: This study aims to investigate and evaluate knowledge and attitude about self-medication using herbal medicine and its drug interaction among the public in Mutah. Materials and methods: A questionnaire-based survey conducted. Survey took place in different locations in the Mutah region in Al-Karak city from Jordan, during December 2017 and January 2018. Data analyzed by SPSS. Results: The majority of responders (82%) use self-prepared herbal preparation. While (56%) go for self-medication rather than visiting a physician. About (63%) participants responded that physicians didn’t ask them about if they use any herbal medication and about (50%) not willing to tell their physician about their self-medication. Knowledge about herbs gained from the family in the first place (38%); TV (21%) and friends (15%). Almost (79%) responders agree that herbs are safer and easier to be used compared to physician-prescribed medicine. Conclusion: A high belief in herbal therapy use. Responders gain their knowledge primarily from their families which they obtain their knowledge primarily from their tradition. They are not aware of their interaction with other therapies. Care-givers in this region should be aware of the high percentage of herbal medicine use and are encouraged to discuss potential use with their patients to avoid future complications.

Knowledge of Herbal Medicines and Herb-drug Interaction Among Medical and Pharmacy Students of the University of Lagos, Nigeria

2020 ◽  
Vol 16 (1) ◽  
pp. 61-70
Author(s):  
O.U. Amaeze ◽  
O.A. Olugbake ◽  
M. Lawal
Keyword(s):  
Drug Interaction ◽  
Herbal Medicine ◽  
Drug Interactions ◽  
Health Care Providers ◽  
Statistical Significance ◽  
Herbal Medicines ◽  
Pharmacy Students ◽  
Care Providers ◽  
Medical Undergraduate ◽  
The University

Background: Concurrent use of herbal and orthodox medicines can result in herb-drug interaction, which could remain unidentified due to the limited knowledge of health care providers on herbal medicines effects and safety.Objectives: This study aimed to assess the knowledge of medical and pharmacy students of the University of Lagos on herbal medicines and herb-drug interactions.Method: The study was a cross-sectional survey of final year pharmacy and medical undergraduate students (422) of the University of Lagos. Data was collected using a validated, previously developed, and standardized self-administered questionnaire. Descriptive statistics was used to evaluate the students’ demographics, knowledge of herbal medicines and herb-drug interactions, types and uses of herbal medicines, while inferential statistics was employed to assess the association between the students’ demographics and their knowledge of herb-drug interactions. Statistical significance was set at P<0.05.Results: The response rate was 97%. The students (98.0%) knew that herbs can be used as medicines; common uses of herbal medicines reported by the students include malaria (11.4%), pain (24.6%), and fever (36.2%). There was no association between the students’ demographics and their knowledge about herbal medicine. Age was significantly associated with knowledge of herb-drug interaction (P<0.05). The students (96.8%) knew that herbs can interact with conventional drugs when administered concurrently. The sources of the students’ knowledge about herbal medicine and herb-drug interaction include lectures (52.2%), literature (14%) and personal experience (13.9%).Conclusion: The students had good knowledge of herbal medicines; however, the subject of herbal medicines and their effects should be given more attention in the medical and pharmacy program curriculum, in order to enhance the students’ knowledge base of herbal medicines and interactions, and equip the future physicians and pharmacists adequately for better patient care. Keywords: Herbal medicines, Herb-drug interaction, Pharmacy students, Medical students

scholarly journals Possible interactions between garlic and conventional drugs: a review

2017 ◽  
Vol 4 (2) ◽  
pp. 73 ◽  
Author(s):  
Mital B. Kansara ◽  
Ashutosh J. Jani
Keyword(s):  
Drug Interaction ◽  
Medicinal Product ◽  
Herbal Medicines ◽  
Herbal Medicinal Product ◽  
Active Constituents ◽  
Conventional Drug ◽  
Single Chemical ◽  
Herbal Medicinal ◽  
Pharmacologically Active ◽  
Interaction Between Drugs

Herbs can affect body function; therefore, when herbs are taken concurrently with drugs, interactions are possible. The interaction between drugs and herbal medicines is a safe concern and these interactions are especially important for drugs with narrow therapeutics index. The probability of herb-drug interaction can be higher than drug interaction, if conventional drug having single chemical entities, whereas most of the herbal medicinal product contain a mixture of pharmacologically active constituents. The herb-drug interaction may involve either an increase or decrease in the amount of drug in blood, either by altering the absorption, distribution, metabolism, and elimination (ADME) of drug and by antagonizing or synergism of the effect of drug or pharmacodynamics interaction may arise. This article we focus on how garlic interacts with conventional drug or it is favourable or not.

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