A nationwide population-based retrospective cohort study: Increased risk of acute myocardial infarction in systemic lupus erythematous patients

Abstract BACKGROUND: We aimed to examine sex differences in mortality after myocardial infarction. METHODS: This retrospective cohort study included all first admitted patients 50 years or older with acute myocardial infarction hospitalized in Rajaei hospital of Karaj city, Iran, between 23th March 2013 and 1th January 2020. Data was retrieved from the hospital information system (HIS) database, including patient’s demographic and socioeconomic characteristics, medical history, acute myocardial infarction (AMI) type, treatment and procedures, and outcome of hospitalization. Simple and multivariate cox regression models were used to assess the association of gender with in-hospital mortality after AMI. Results were presented as crude and adjusted hazard ratios along with their 95% confidence interval (HR (95% CI).RESULTS: Results from the multivariable Cox regression analysis revealed that females had a higher risk of death than males after ST segment Elevation MI (STEMI) (adjusted HR (95% CI): 1.64 (1.15 – 2.36), P=0.007). However, in subgroup analysis by age groups, this significant increased risk was observed only in female patients aged 50 to 64 years than their male counterparts. There was no significant differences between males and females after non-STEMI and unspecified MI.CONCLUSIONS: Based on our findings, women aged 50 to 64 years may be more likely to die during hospitalization after STEMI than men.

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Outcomes in a diabetic population of south Asians and whites following hospitalization for acute myocardial infarction: a retrospective cohort study

Cardiovascular Diabetology ◽

10.1186/1475-2840-9-4 ◽

2010 ◽

Vol 9 (1) ◽

pp. 4 ◽

Cited By ~ 10

Author(s):

Aman PK Nijjar ◽

Hong Wang ◽

Kaberi Dasgupta ◽

Doreen M Rabi ◽

Hude Quan ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

South Asians ◽

Diabetic Population

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Increased risk of pyogenic liver abscess in patients with alcohol intoxication: A population-based retrospective cohort study

Alcohol ◽

10.1016/j.alcohol.2017.05.003 ◽

2017 ◽

Vol 64 ◽

pp. 23-28 ◽

Cited By ~ 2

Author(s):

Yao-Chien Wang ◽

Kai-Wei Yang ◽

Tien-Ying Peter Lee ◽

Cheng-Li Lin ◽

Geng-Wang Liaw ◽

...

Keyword(s):

Cohort Study ◽

Liver Abscess ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Alcohol Intoxication ◽

Pyogenic Liver Abscess ◽

Population Based ◽

Increased Risk

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Should erectile dysfunction be considered as a marker for acute myocardial infarction? Results from a retrospective cohort study

International Journal of Impotence Research ◽

10.1038/sj.ijir.3901174 ◽

2004 ◽

Vol 16 (4) ◽

pp. 350-353 ◽

Cited By ~ 112

Author(s):

W A Blumentals ◽

A Gomez-Caminero ◽

S Joo ◽

V Vannappagari

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Cohort Study ◽

Erectile Dysfunction ◽

Retrospective Cohort Study ◽

Retrospective Cohort

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Increased risk of rheumatoid arthritis among patients with endometriosis: a nationwide population-based cohort study

Rheumatology ◽

10.1093/rheumatology/keaa784 ◽

2020 ◽

Author(s):

Yu-Hao Xue ◽

Liang-Tian You ◽

Hsin-Fu Ting ◽

Yu-Wen Chen ◽

Zi-Yun Sheng ◽

...

Keyword(s):

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Propensity Scores ◽

Population Based ◽

Cox Proportional Hazard ◽

Kaplan Meier ◽

Increased Risk ◽

Potential Risks ◽

Using Data

Abstract Objectives Autoimmunity may play a role in endometriosis. The association between endometriosis and RA remains unknown. This study was conducted to identify any evidence for this relationship. Methods This 13-year, nationwide, population-based, retrospective cohort study analysed the risk of RA in a cohort of individuals with endometriosis. We investigated the incidence of RA among patients with endometriosis using data from the Longitudinal Health Insurance Database 2000, which is maintained by the Taiwan National Health Research Institutes. We used propensity scores to match comorbidities in the two cohorts. Kaplan–Meier analysis and Cox proportional hazard model were employed to analyse the association between endometriosis and RA among patients with different potential risks. Results Patients with endometriosis [adjusted hazard ratio (HR) 1.75, 95% CI 1.27, 2.41], aged ≥45 years (adjusted HR 1.50, 95% CI 1.06–2.13) and with autoimmune disease (adjusted HR 6.99, 95% CI 2.84–17.21) had a significantly higher risk of RA. The analyses also showed that when stratified by age, comorbidities and medication use, the risk of RA in patients with endometriosis was also higher than in those without endometriosis. Conclusions This 14-year, nationwide, population-based retrospective cohort study revealed that patients with endometriosis have a higher risk of RA. In the clinical management of patients with RA, rheumatologists should be especially mindful of the possibility of underlying endometriosis.

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Trajectories of risk after hospitalization for heart failure, acute myocardial infarction, or pneumonia: retrospective cohort study

BMJ ◽

10.1136/bmj.h411 ◽

2015 ◽

Vol 350 (feb05 19) ◽

pp. h411-h411 ◽

Cited By ~ 94

Author(s):

K. Dharmarajan ◽

A. F. Hsieh ◽

V. T. Kulkarni ◽

Z. Lin ◽

J. S. Ross ◽

...

Keyword(s):

Myocardial Infarction ◽

Heart Failure ◽

Acute Myocardial Infarction ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort

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High thrombotic risk increases adverse clinical events up to 5 years after acute myocardial infarction. A nationwide retrospective cohort study

Monaldi Archives for Chest Disease ◽

10.4081/monaldi.2019.1166 ◽

2019 ◽

Vol 89 (3) ◽

Cited By ~ 1

Author(s):

Gian Francesco Mureddu ◽

Cesare Greco ◽

Stefano Rosato ◽

Paola D'Errigo ◽

Leonardo De Luca ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Recurrent Events ◽

First Year ◽

Thrombotic Risk ◽

Clinical Events ◽

Cerebrovascular Events

The risk of recurrent events among survivors of acute myocardial infarction (AMI) is understudied. The aim of this analysis was to investigate the role of residual high thrombotic risk (HTR) as a predictor of recurrent in-hospital events after AMI. This retrospective cohort study included 186,646 patients admitted with AMI from 2009 to 2010 in all Italian hospitals who were alive 30 days after the index event. HTR was defined as at least one of the following in the 5 years preceding AMI: previous myocardial infarction, ischemic stroke/other vascular disease, type 2 diabetes mellitus, renal failure. Risk adjustment was performed in all multivariate survival analyses. Rates of major cardiac and cerebrovascular events (MACCE) within the following 5 years were calculated in both patients without fatal readmissions at 30 days and in those free from in-hospital MACCE at 1 year from the index hospitalization. The overall 5-year risk of MACCE was higher in patients with HTR than in those without HTR, in both survivors at 30 days [hazard ratio (HR), 1.49; 95% confidence interval (CI), 1.45-1.52; p<0.0001] and in those free from MACCE at 1 year (HR, 1.46; 95% CI, 1.41-1.51; p<0.0001). The risk of recurrent MACCE increased in the first 18 months after AMI (HR, 1.49) and then remained stable over 5 years. The risk of MACCE after an AMI endures over 5 years in patients with HTR. This is also true for patients who did not have any new cardiovascular event in the first year after an AMI. All patients with HTR should be identified and addressed to intensive preventive care strategies.

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Trends in self-poisoning and psychotropic drug use in people aged 5–19 years: a population-based retrospective cohort study in Australia

BMJ Open ◽

10.1136/bmjopen-2018-026001 ◽

2019 ◽

Vol 9 (2) ◽

pp. e026001 ◽

Cited By ~ 7

Author(s):

Rose Cairns ◽

Emily A Karanges ◽

Anselm Wong ◽

Jared A Brown ◽

Jeff Robinson ◽

...

Keyword(s):

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Selective Serotonin Reuptake Inhibitors ◽

Age Groups ◽

Cohort Effect ◽

Population Based ◽

Psychotropic Medicine ◽

Increased Risk ◽

Self Harm

ObjectivesTo characterise trends in self-poisoning and psychotropic medicine use in young Australians.DesignPopulation-based retrospective cohort study.SettingCalls taken by the New South Wales and Victorian Poisons Information Centres (2006–2016, accounting for 70% of Australian poisoning calls); medicine dispensings in the 10% sample of Australian Pharmaceutical Benefits Scheme data (July 2012 to June 2016).ParticipantsPeople aged 5–19 years.Main outcome measuresYearly trends in intentional poisoning exposure calls, substances taken in intentional poisonings, a prevalence of psychotropic use (dispensing of antidepressants, antipsychotics, benzodiazepines and medicines for attention deficit hyperactivity disorder (ADHD)).ResultsThere were 33 501 intentional poisonings in people aged 5–19 years, with an increase of 8.39% per year (95% CI 6.08% to 10.74%, p<0.0001), with a 98% increase overall, 2006–2016. This effect was driven by increased poisonings in those born after 1997, suggesting a birth cohort effect. Females outnumbered males 3:1. Substances most commonly taken in self-poisonings were paracetamol, ibuprofen, fluoxetine, ethanol, quetiapine, paracetamol/opioid combinations, sertraline and escitalopram. Psychotropic dispensing also increased, with selective serotonin reuptake inhibitors (SSRIs) increasing 40% and 35% July 2012 to June 2016 in those aged 5–14 and 15–19, respectively. Fluoxetine was the most dispensed SSRI. Antipsychotics increased by 13% and 10%, while ADHD medication dispensing increased by 16% and 10%, in those aged 5–14 and 15–19, respectively. Conversely, dispensing of benzodiazepines to these age groups decreased by 4% and 5%, respectively.ConclusionsOur results signal a generation that is increasingly engaging in self-harm and is increasingly prescribed psychotropic medications. These findings indicate growing mental distress in this cohort. Since people who self-harm are at increased risk of suicide later in life, these results may foretell future increases in suicide rates in Australia.

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