Tricuspid systolic peak velocity is a prognostic factor in patients with cystic fibrosis

Diameter, blood velocity, and flow of the brachial artery and vascular resistance of the brachial circulation were evaluated with a pulsed Doppler velocimeter before and after wrist occlusion in 8 younger and 8 older normotensive subjects and in 11 younger and 11 older hypertensive patients. Before occlusion, no differences existed between younger and older normotensives. However, in hypertensives, systolic peak velocity was higher in younger than in older hypertensives (P less than 0.001) and correlated to age in the overall patients (r = -0.57, P less than 0.01). Occlusion decreased velocity and flow and increased vascular resistance in all groups, but the change in resistance was not correlated with the base-line resistance. During occlusion, no differences existed between younger and older normotensives. However, in hypertensives mean and systolic peak velocity was higher (P less than 0.01), and vascular resistance was lower (P less than 0.01) in younger than in older patients. In hypertensive patients, during occlusion mean and systolic peak velocity were negatively correlated to age (r = -0.72, P less than 0.001; r = -0.59, P less than 0.01), and vascular resistance was positively related to age (r = +0.66, P less than 0.001). Thus wrist occlusion modified the brachial circulation in normotensive and hypertensive populations but revealed age-related differences only in hypertensive patients, suggesting a combined effect of age and hypertension on the muscle vascular bed.

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Increased Systolic Peak Velocity in Fetal Middle Cerebral Artery Blood Flow Shown by Doppler Sonography in Acute Fetomaternal Hemorrhage

Journal of Ultrasound in Medicine ◽

10.7863/jum.2005.24.2.243 ◽

2005 ◽

Vol 24 (2) ◽

pp. 243-246 ◽

Cited By ~ 7

Author(s):

Geoffrey Wong ◽

Deborah Levine

Keyword(s):

Blood Flow ◽

Middle Cerebral Artery ◽

Cerebral Artery ◽

Doppler Sonography ◽

Peak Velocity ◽

Artery Blood Flow ◽

Fetomaternal Hemorrhage ◽

Systolic Peak Velocity

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Dilatation of the ductus venosus in human fetuses: ultrasonographic evidence and mathematical modeling

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.1998.275.5.h1759 ◽

1998 ◽

Vol 275 (5) ◽

pp. H1759-H1767 ◽

Cited By ~ 16

Author(s):

M. Bellotti ◽

G. Pennati ◽

G. Pardi ◽

R. Fumero

Keyword(s):

Blood Flow ◽

Flow Velocity ◽

Peak Velocity ◽

Umbilical Vein ◽

Venous Pressure ◽

Circulation Model ◽

Blood Flow Rate ◽

Ductus Venosus ◽

Human Fetuses ◽

Systolic Peak Velocity

Autonomic regulation of blood flow through the fetal ductus venosus has been suggested, but the existence of a sphincter at the ductal entrance in human fetuses has yet to be established. In this paper two cases of apparent ductus venosus dilatation in two growth-restricted human fetuses are reported. Prolonged ultrasonographic analysis (45 min) showed rapid and substantial changes (>80%) of ductal diameters. Pulsed Doppler analysis was used to investigate flow velocity in the ductus venosus and umbilical vein for both normal and dilated conditions. Dilated conditions caused manifest modifications of velocity tracings. Systolic peak velocity in the ductus did not change visibly, whereas velocity at the atrial contraction showed evident reduction; consequently, pulsatility indexes increased. Furthermore, the umbilical vein presented flow velocity pulsations. The mean blood flow rate through the ductus seemed to increase substantially (>70%) for high dilatation. To investigate these findings further, we performed simulations of ductal dilatation by means of a lumped-parameter mathematical model of the human fetal circulation. Model results agreed with clinical evidence and confirmed the relationship between ductal dilatation and the observed velocity alterations. Simulated systolic peak velocity slightly increased for small dilatation (<30%), whereas atrial velocity was reduced when the ductus dilated. Furthermore, the model indicated that umbilical venous pressure decreases for increasing dilatation, whereas no change occurs in the central venous pressure. The present results seem to indicate the presence of active dilatation of the ductus venosus in human fetuses.

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Nutritional Status in Childhood as a Prognostic Factor in Patients with Cystic Fibrosis

Lung ◽

10.1007/s00408-019-00218-3 ◽

2019 ◽

Vol 197 (3) ◽

pp. 371-376 ◽

Cited By ~ 6

Author(s):

Moshe Ashkenazi ◽

N. Nathan ◽

I. Sarouk ◽

B. E. Bar Aluma ◽

A. Dagan ◽

...

Keyword(s):

Cystic Fibrosis ◽

Prognostic Factor ◽

Nutritional Status

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Abstract 13078: Evaluation of Ventricular Function in Fetus With Transposition of Great Arteries by Velocity Vector Imaging

Circulation ◽

10.1161/circ.142.suppl_3.13078 ◽

2020 ◽

Vol 142 (Suppl_3) ◽

Author(s):

Mingxing XIE ◽

Lin Shan ◽

Lv Qing ◽

Wang Jing ◽

Zhang Li ◽

...

Keyword(s):

Strain Rate ◽

Ventricular Function ◽

Velocity Vector ◽

Peak Velocity ◽

Left Ventricular ◽

Control Group ◽

Mechanical Function ◽

Velocity Vector Imaging ◽

Independent Determinant ◽

Systolic Peak Velocity

Background: The aim of this study was to test the hypotheses that (1) fetuses with complete transposition of the great arteries (D-TGA) and Taussig-Bing anomaly (TBA) has decreased the left ventricular (LV) and right ventricular(RV) mechanical function compared with normal fetuses, and (2)the decreased myocardial mechanical function in fetal D-TGA and TBA was associated with the degree of transposition of the great arteries, pulmonary stenosis(PS) and ventricular septal defect(VSD). Methods: We retrospectively identified 49 cases of fetal D-TGA and 29 cases of fetal TBA and compared findings to 49 controls of comparable gestational age. Postprocessing analysis of the left ventricle and right ventricle were done using syngo Velocity Vector Imaging version 2.3. Global and regional longitudinal systolic peak velocity, strain and strain rate were generated. Results: (1) Comparing with control group, the global and regional longitudinal systolic peak velocity (GLV), strain (GLS) and strain rate (GLSR) of the LV and RV were decreased in the group of D-TGA and TBA (P<0.05). (2) In the group of D-TGA and TBA, the multivariate linear regression analysis, the VSD was the independent determinant of LVGLS and RVGLS (β = 0.270, P=0.014 and β = 0.465, P< 0.001). The PS was the independent determinant of RVGLSR (β = 0.090, P=0.009). Conclusion: The ventricular function of fetal D-TGA and TBA were decreased compared with control group. The PS and VSD were the independent determinant factors of the decreased LVGLS, RVGLS and RVGLSR in the fetal D-TGA and TBA.

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Liver disease in adult patients with cystic fibrosis: A frequent and independent prognostic factor associated with death or lung transplantation

Journal of Hepatology ◽

10.1016/j.jhep.2011.03.028 ◽

2011 ◽

Vol 55 (6) ◽

pp. 1377-1382 ◽

Cited By ~ 42

Author(s):

Ariane Chryssostalis ◽

Dominique Hubert ◽

Joël Coste ◽

Reem Kanaan ◽

Pierre-Régis Burgel ◽

...

Keyword(s):

Cystic Fibrosis ◽

Liver Disease ◽

Prognostic Factor ◽

Lung Transplantation ◽

Independent Prognostic Factor ◽

Adult Patients

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Abstract 3340: Coronary Flow Velocity Pattern Immediately After Percutaneous Coronary Intervention Predicts Left Ventricular Remodeling in Patients with Acute Myocardial Infarction

Circulation ◽

10.1161/circ.116.suppl_16.ii_752-c ◽

2007 ◽

Vol 116 (suppl_16) ◽

Author(s):

Atsushi Yamamuro ◽

Takashi Akasaka ◽

Shuichiro Kaji ◽

Koichi Tamita ◽

Minako Katayama ◽

...

Keyword(s):

Coronary Flow ◽

Peak Velocity ◽

Coronary Intervention ◽

Left Ventricular ◽

Volume Index ◽

End Diastolic Volume ◽

Percutaneous Coronary ◽

Lv Remodeling ◽

Systolic Peak Velocity ◽

Deceleration Time

Background: Studies using the Doppler guidewire have shown that coronary flow velocity (CFV) pattern in recanalized infracted arteries predicts recovery of regional left ventricular (LV) function, in-hospital complications, and long-term cardiac events. However, the relationship between the CFV pattern after reperfusion and serial changes in LV volumes is not clear. We postulated that the quantitative CFV measurement immediately after successful percutaneous coronary intervention (PCI) might be associated with the LV remodeling. To test this hypothesis, we prospectively analyzed the LV remodeling according to CFV parameters measured by the Doppler guidewire in patients with acute myocardial infarction (AMI). Methods: Consecutive 211 patients with first-time anterior AMI underwent successful PCI (<50% residual stenosis with TIMI flow grade 2–3) and coronary flow measurement with the Doppler guidewire. The CFV spectrum provided the following parameters: time-averaged peak velocity (cm/s), systolic peak velocity (cm/s), and diastolic deceleration time (ms). Left ventriculograms obtained immediately after PCI and 6 months after the infarction were analyzed to measure the end-diastolic volume index and end-systolic volume index. The LV remodeling was defined as an increase in end-diastolic volume index ≥20%. Result: The optimal cutoff values to predict LV remodeling (defined as 6-month LV dilation ≥20%) were 20 cm/s for time-averaged peak velocity, 0 cm/s for systolic peak velocity and 550 ms for diastolic deceleration time (sensitivity=0.63, specificity=0.56; sensitivity=0.76, specificity=0.85; and sensitivity=0.85, specificity=0.85, respectively). Systolic peak velocity and diastolic deceleration time correlated to the LV end-diastolic volume index obtained 6 months after AMI(r= −0.67; p<0.001 and r= −0.78; p<0.001, respectively). Conclusions: The CFV pattern appears to be an accurate predictor of LV remodeling even in patients who received successful PCI in the left anterior descending coronary artery immediately after AMI. This index, therefore, identifies a subset of patients at-risk.

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