LDL-oxidation, serum uric acid, kidney function and pulse-wave velocity: Data from the Brisighella Heart Study cohort

Aim. To evaluate the single pill combination with lisinopril, amlodipine and indapamide ability in additional angioprotection achievement in patients with arterial hypertension and high pulse wave velocity (PWV) regardless on previous antihypertensive therapy (AHT).Material and methods. To the open non-randomized study duration 12 weeks 40 patients were included taking triple AHT during 6 months. All participants underwent ambulatory 24 hour blood pressure (BP) monitoring, applanation tonometry (augmentation index and central BP), pulse wave velocity assessment, laboratory tests (HbA1c, serum uric acid, high sensitive C-reactive protein [hsCRP], serum uric acid).Results. We observed additional systolic BP (SBP) and diastolic BP (DBP) reduction by 16.9% and 22.11% on lisinopril, amlodipine and indapamide single pill combination. Lisinopril, amlodipine and indapamide single pill combination decreased 24 h mean SBP by 16.77%, and 24 h mean DBP -23.5% (ABPM data), PWV by 19.7%, augmentation index by 14.81%, central SBP by 11.9% (p<0,05). There were positive changes in hsCRP level (-13.0%, p<0.05) and serum uric acid (-9.0%, p<0.05).Conclusion. Lisinopril, amlodipine and indapamide single pill combination provided control BP, arterial elastic properties improving (augmentation index, PWV, central BP) and favorable influence on inflammation and serum uric acid level.

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MASKED HYPERTENSION HAS HIGHER SERUM URIC ACID LEVEL AND PULSE WAVE VELOCITY THAN SUSTAINED NORMOTENSION, EVEN IN LOW RISK POPULATION

Journal of Hypertension ◽

10.1097/01.hjh.0000571272.32139.ea ◽

2019 ◽

Vol 37 ◽

pp. e97-e98

Author(s):

M. Rhee ◽

S. Roh ◽

J. Kim ◽

D. Nah

Keyword(s):

Uric Acid ◽

Pulse Wave Velocity ◽

Serum Uric Acid ◽

Wave Velocity ◽

Uric Acid Level ◽

Acid Level ◽

Pulse Wave ◽

Serum Uric Acid Level ◽

Low Risk ◽

Masked Hypertension

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PREVALENCE OF THE METABOLIC SYNDROME IN HYPERTENSION, AND CORRELATION BETWEEN THE PRESENCE OF CORONARY ARTERY DISEASE AND PULSE WAVE VELOCITY, AND SERUM URIC ACID

Journal of Hypertension ◽

10.1097/00004872-200406002-00573 ◽

2004 ◽

Vol 22 (Suppl. 2) ◽

pp. S167-S168

Author(s):

H. E. Lim ◽

C. G. Park ◽

S. M. Park ◽

S. H. Shin ◽

J. C. Ahn ◽

...

Keyword(s):

Coronary Artery Disease ◽

Metabolic Syndrome ◽

Uric Acid ◽

Coronary Artery ◽

Pulse Wave Velocity ◽

Serum Uric Acid ◽

Wave Velocity ◽

Pulse Wave ◽

The Metabolic Syndrome ◽

Artery Disease

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The Relationships of the Fractional Excretion of Uric Acid with Brachial-Ankle Pulse Wave Velocity and Ankle Brachial Index in Chinese Young Adults

Kidney & Blood Pressure Research ◽

10.1159/000487677 ◽

2018 ◽

Vol 43 (1) ◽

pp. 234-245 ◽

Cited By ~ 3

Author(s):

Jia-Wen Hu ◽

Yang Wang ◽

Chao Chu ◽

Yu Yan ◽

Keke Wang ◽

...

Keyword(s):

Young Adults ◽

Uric Acid ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

Ankle Brachial Index ◽

Fractional Excretion ◽

Chinese Young Adults

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Early and Supernormal Vascular Aging

Hypertension ◽

10.1161/hypertensionaha.120.14971 ◽

2020 ◽

Vol 76 (5) ◽

pp. 1616-1624 ◽

Cited By ~ 2

Author(s):

Rosa Maria Bruno ◽

Peter M. Nilsson ◽

Gunnar Engström ◽

Benjamin Nilsson Wadström ◽

Jean-Philippe Empana ◽

...

Keyword(s):

Pulse Wave Velocity ◽

Wave Velocity ◽

Cardiovascular Events ◽

Pulse Wave ◽

Hazard Ratio ◽

Study Cohort ◽

Vascular Aging ◽

Cancer Study ◽

Vascular Age ◽

Diet And Cancer

Pulse wave velocity is an established marker of early vascular aging but may also help identifying individuals with supernormal vascular aging. We tested the hypothesis that individuals with the largest difference (Δ-age) between chronological and vascular age show the lowest rate of cardiovascular events and may thus be defined as supernormal vascular aging. Vascular age was defined as the predicted age in the best fitting multivariable regression model including classical risk factors and treatment and pulse wave velocity, in a subset of the Reference Values for Arterial Stiffness Collaboration Database (n=3347). Δ-age was then calculated as chronological age minus vascular age, and the 10th and 90th percentiles were used to define early (Δ-age<−5.7 years), normal (Δ-age −5.7 to 6.8 years) and supernormal vascular aging (Δ-age>6.8 years). The risk for fatal and nonfatal cardiovascular events associated with vascular aging categories was investigated in the Malmö Diet and Cancer Study cohort (n=2642). In the Malmö Diet and Cancer Study Cohort (6.6-year follow-up, 286 events), Δ-age was significantly ( P <0.01) and inversely associated with cardiovascular events. Compared with normal vascular aging, supernormal vascular aging had lower risk (hazard ratio, 0.59 [95% CI, 0.41–0.85]), whereas early vascular aging had higher risk (hazard ratio, 2.70 [95% CI, 1.55–4.70]) of cardiovascular events, in particular coronary events. There was no significant association with all-cause mortality. This study represents the first validation of the clinical significance of the supernormal vascular aging concept, based on prospective data. Its further characterization may help discovering novel protective molecular pathways and providing preventive strategies for successful vascular aging.

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