Left ventricular hypertrophy in athletes, a case-control analysis of interindividual variability

2021 ◽  
Author(s):  
Stefano Caselli ◽  
Marco Cicconetti ◽  
David Niederseer ◽  
Christian Schmied ◽  
Christine Attenhofer Jost ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Interindividual Variability ◽  
Case Control ◽  
Left Ventricular ◽  
Control Analysis ◽  
Case Control Analysis

Abstract 16663: Patient and Cell Characteristics Associated With Clinical Outcomes in the CCTRN LateTIME Trial

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Aruni Bhatnagar ◽  
Brian H Johnston ◽  
Jay H Traverse ◽  
Timothy D Henry ◽  
Carl J Pepine ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Clinical Outcomes ◽  
Wall Motion ◽  
Case Control ◽  
Left Ventricular ◽  
Border Zone ◽  
Lv Function ◽  
Control Analysis ◽  
Lv Dysfunction ◽  
Case Control Analysis

Background and Hypothesis: In the CCTRN LateTIME trial, there was no improvement versus placebo in cardiac function 6 months after intracoronary infusion of autologous bone marrow mononuclear cells (BMC), 2-3 weeks post-MI. We hypothesized that clinical outcomes are associated with patient demographics and BMC populations that contribute to the efficacy of the intervention. Methods: Left ventricular (LV) function was evaluated at baseline and at 6 months. BMC study product data associated with phenotype and colony formation capability were collected at baseline. Principal components analysis was used to define a composite variable, LV dysfunction, encompassing both LV volume and wall motion data. Case control analysis was then conducted comparing those with improved LV dysfunction (cases) with those without (controls). Results: Hypertension, diabetes, and obesity were associated with lower levels of endothelial progenitor cells; whereas hyperlipidemia was inversely associated with CD11b+ cells, and obesity with CD3+ cells. Adjusted multivariate analysis indicated that CD11b+ cells were negatively associated with LV function; both globally (P<0.02) and regionally (P<0.01 and P<0.001, border and infarct zone wall motion, respectively). Global LV function was positively associated with MSC colonies formed (P<0.02) and regional LV function (border zone wall motion) and with cell viability (P<0.03). Case control analysis revealed a significant association of CD133+, CD34+/CD31+, and CXCR4dim cells with cases. Increased LV dysfunction was associated with CD11b+cells. Conclusions: These results suggest that CVD risk factors significantly affect BMC and that baseline BMC characteristics of individual patients may be important determinants of clinical improvement. Higher frequencies or better function of specific cell populations with endothelial, mesenchymal and migratory phenotype may predispose patients to clinical improvements, whereas higher level of CD11b+ in the BM may contribute to impaired LV function. Product selection or treatment to modify bone marrow constituents, such as negative selection of CD11b+ cells prior to BMC injection, may be a potential strategy to improve outcomes of future clinical trials.

scholarly journals Association of ACE gene D polymorphism with left ventricular hypertrophy in patients with diastolic heart failure: a case–control study

BMJ Open ◽  
2016 ◽  
Vol 6 (2) ◽  
pp. e010282 ◽  
Author(s):  
Ehsan Bahramali ◽  
Mona Rajabi ◽  
Javad Jamshidi ◽  
Seyyed Mohammad Mousavi ◽  
Mehrdad Zarghami ◽  
...  
Keyword(s):  
Heart Failure ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Case Control Study ◽  
Diastolic Heart Failure ◽  
Case Control ◽  
Left Ventricular ◽  
Ace Gene ◽  
Control Study

scholarly journals Hubungan antara Kebiasaan Merokok dan Hipertrofi Ventrikel Kiri pada Laki-laki Dewasa Muda dengan Obesitas Sentral

2018 ◽  
Vol 10 (3) ◽  
pp. 174
Author(s):  
Ribka Wowor
Keyword(s):  
Risk Factor ◽  
Young Adult ◽  
Left Ventricular Hypertrophy ◽  
Central Obesity ◽  
Ventricular Hypertrophy ◽  
Case Control ◽  
Left Ventricular ◽  
Control Group ◽  
Case Group ◽  
Adult Men

Abstract: Left ventricular hypertrophy (LVH) is an independent risk factor for mortality. This state should be prevented by controlling the underlying factor, such as smoking. This study was aimed to determine the association between smoking and left ventricular hypertrophy in young adult men with central obesity. This was a case control study, conducted at Cardiology Department of Prof. Dr. R. D. Kandou Hospital in Manado from January to March 2015. Subjects were young adult male students (18-30 years old) at Prof. Dr. R. D. Kandou Hospital with central obesity divided into two groups: case group and control group. The case group consisted of 31 subjects with LVH meanwhile the control group consisted of 21 subjects without LVH. The statistical analysis showed that smoking was a risk factor for LVH in young adult men with central obesity, but not statistically significant (OR=3.846; 95% CI: 0.494-14.901; P=0.432). Conclusion: Smoking is a risk factor of left ventricular hypertrophy in young adult men (<30 years old) with central obesity, but not statistically significant.Keywords: smoking, left ventricular hypertrophy, young adult men, central obesityAbstrak: Hipertrofi ventrikel kiri (HVK) merupakan salah satu prediktor kematian independen. Pembesaran jantung kiri sebenarnya merupakan keadaan yang dapat dicegah dengan pengendalian faktor risiko, salah satunya ialah merokok. Penelitian ini bertujuan untuk mengetahui hubungan antara kebiasaan merokok dan hipertrofi ventrikel kiri pada laki-laki dewasa muda dengan obesitas sentral. Jenis penelitian ialah penelitian kuantitatif metode analitik dengan menggunakan rancangan case-control. Penelitian dilaksanakan di Bagian Kardiologi RSUP Prof. Dr. R. D. Kandou Manado selama 3 (tiga) bulan, yaitu dari bulan Januari 2015 s/d Maret 2015. Subyek penelitian ialah laki-laki dewasa muda (usia 18-30 tahun) dengan obesitas sentral dan sementara menjalani KKM di RSUP Prof. Dr. R. D. Kandou Manado. Subyek yang mengalami HVK sebagai kelompok kasus dan yang tidak mengalami HVK sebagai kelompok kontrol. Hasil penelitian mendapatkan bahwa kebiasaan merokok merupakan faktor risiko terjadinya HVK pada laki-laki dewasa muda dengan obesitas sentral walaupun secara statistik tidak bermakna (OR=3,846; 95% CI: 0,494-14,901; P=0,432). Simpulan: Kebiasaan merokok merupakan faktor risiko terjadinya pembesaran jantung kiri pada laki-laki dewasa muda (<30 tahun), walaupun secara statistik tidak bermakna.Kata kunci: merokok, hipertrofi ventrikel kiri, dewasa muda, obesitas sentral

Left Ventricular Hypertrophy

2014 ◽  
Vol 19 (2) ◽  
pp. 11-15
Author(s):  
Steven L. Demeter
Keyword(s):  
Risk Factors ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Left Ventricular Mass Index ◽  
Medical Science ◽  
Careful Analysis ◽  
Left Ventricular ◽  
Hypertensive Disease ◽  
Accurate Analysis ◽  
Clear Explanation

Abstract The fourth, fifth, and sixth editions of the AMA Guides to the Evaluation of Permanent Impairment (AMA Guides) use left ventricular hypertrophy (LVH) as a variable to determine impairment caused by hypertensive disease. The issue of LVH, as assessed echocardiographically, is a prime example of medical science being at odds with legal jurisprudence. Some legislatures have allowed any cause of LVH in a hypertensive individual to be an allowed manifestation of hypertensive changes. This situation has arisen because a physician can never say that no component of LVH was not caused by the hypertension, even in an individual with a cardiomyopathy or valvular disorder. This article recommends that evaluators consider three points: if the cause of the LVH is hypertension, is the examinee at maximum medical improvement; is the LVH caused by hypertension or another factor; and, if apportionment is allowed, then a careful analysis of the risk factors for other disorders associated with LVH is necessary. The left ventricular mass index should be present in the echocardiogram report and can guide the interpretation of the alleged LVH; if not present, it should be requested because it facilitates a more accurate analysis. Further, if the cause of the LVH is more likely independent of the hypertension, then careful reasoning and an explanation should be included in the impairment report. If hypertension is only a partial cause, a reasoned analysis and clear explanation of the apportionment are required.

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