ISDN2014_0414: Effects of developmental ethanol exposures in wildtype and p53‐null mice on transcriptional and epigenetic regulation of DNA damage repair, cell cycle, cell fate and cell death processes

2015 ◽  
Vol 47 (Part_A) ◽  
pp. 124-125 ◽  
Author(s):  
F.A. Middleton ◽  
C. Ignacio ◽  
M. Camargo ◽  
S. Hicks ◽  
S. Mooney
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Cell Death ◽  
Cell Fate ◽  
Epigenetic Regulation ◽  
Dna Damage Repair ◽  
Damage Repair

Context-Dependent Functions of E2F1: Cell Cycle, Cell Death, and DNA Damage Repair in Cortical Neurons

2020 ◽  
Vol 57 (5) ◽  
pp. 2377-2390
Author(s):  
Yang Zhang ◽  
Xuan Song ◽  
Karl Herrup
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Cell Death ◽  
Cortical Neurons ◽  
Dna Damage Repair ◽  
Damage Repair ◽  
Context Dependent

scholarly journals Human POLD1 modulates cell cycle progression and DNA damage repair

2015 ◽  
Vol 16 (1) ◽  
Author(s):  
Jing Song ◽  
Ping Hong ◽  
Chengeng Liu ◽  
Yueqi Zhang ◽  
Jinling Wang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Cell Cycle Progression ◽  
Dna Damage Repair ◽  
Cycle Progression ◽  
Damage Repair

Abstract 1010: A study of combinatorial growth inhibition, cell death and DNA damage repair caused by CHK1 inhibitor SRA737 and WEE1 inhibitor adavosertib in TP53 mutated cell lines

2021 ◽  
Author(s):  
Adam Stewart ◽  
Lisa Pickard ◽  
Albert E. Hallsworth ◽  
Sylvie Sauvaigo ◽  
Giovanna Muggiolu ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cell Death ◽  
Growth Inhibition ◽  
Cell Lines ◽  
Dna Damage Repair ◽  
Damage Repair ◽  
Chk1 Inhibitor

scholarly journals Effects of different doses of X‑ray irradiation on cell apoptosis, cell cycle, DNA damage repair and glycolysis in HeLa cells

2018 ◽  
Author(s):  
Hong Zhao ◽  
Yafei Zhuang ◽  
Ruibin Li ◽  
Yinyin Liu ◽  
Zijie Mei ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Hela Cells ◽  
Cell Apoptosis ◽  
Dna Damage Repair ◽  
X Ray ◽  
Damage Repair ◽  
Different Doses

scholarly journals Changes in DNA Damage Repair Gene Expression and Cell Cycle Gene Expression Do Not Explain Radioresistance in Tamoxifen-Resistant Breast Cancer

2020 ◽  
Vol 28 (1) ◽  
pp. 33-40 ◽  
Author(s):  
Annemarie E. M. Post ◽  
Johan Bussink ◽  
Fred C. G. J. Sweep ◽  
Paul N. Span
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cell Cycle ◽  
Dna Damage ◽  
Dna Damage Repair ◽  
Cross Resistance ◽  
Damage Repair ◽  
Breast Cancer Cohort ◽  
Tamoxifen Resistant ◽  
Repair Genes

Tamoxifen-induced radioresistance, reported in vitro, might pose a problem for patients who receive neoadjuvant tamoxifen treatment and subsequently receive radiotherapy after surgery. Previous studies suggested that DNA damage repair or cell cycle genes are involved, and could therefore be targeted to preclude the occurrence of cross-resistance. We aimed to characterize the observed cross-resistance by investigating gene expression of DNA damage repair genes and cell cycle genes in estrogen receptor-positive MCF-7 breast cancer cells that were cultured to tamoxifen resistance. RNA sequencing was performed, and expression of genes characteristic for several DNA damage repair pathways was investigated, as well as expression of genes involved in different phases of the cell cycle. The association of differentially expressed genes with outcome after radiotherapy was assessed in silico in a large breast cancer cohort. None of the DNA damage repair pathways showed differential gene expression in tamoxifen-resistant cells compared to wild-type cells. Two DNA damage repair genes were more than two times upregulated (NEIL1 and EME2), and three DNA damage repair genes were more than two times downregulated (PCNA, BRIP1, and BARD1). However, these were not associated with outcome after radiotherapy in the TCGA breast cancer cohort. Genes involved in G1, G1/S, G2, and G2/M phases were lower expressed in tamoxifen-resistant cells compared to wild-type cells. Individual genes that were more than two times upregulated (MAPK13) or downregulated (E2F2, CKS2, GINS2, PCNA, MCM5, and EIF5A2) were not associated with response to radiotherapy in the patient cohort investigated. We assessed the expression of DNA damage repair genes and cell cycle genes in tamoxifen-resistant breast cancer cells. Though several genes in both pathways were differentially expressed, these could not explain the cross-resistance for irradiation in these cells, since no association to response to radiotherapy in the TCGA breast cancer cohort was found.

scholarly journals New Insights into PARP Inhibitors' Effect on Cell Cycle and Homology-Directed DNA Damage Repair

2014 ◽  
Vol 13 (6) ◽  
pp. 1645-1654 ◽  
Author(s):  
Petar Jelinic ◽  
Douglas A. Levine
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Dna Damage Repair ◽  
Parp Inhibitors ◽  
Damage Repair

Oxidative stress-induced CREB upregulation promotes DNA damage repair prior to neuronal cell death protection

2016 ◽  
Vol 425 (1-2) ◽  
pp. 9-24 ◽  
Author(s):  
Nicolás Pregi ◽  
Laura María Belluscio ◽  
Bruno Gabriel Berardino ◽  
Daniela Susana Castillo ◽  
Eduardo Tomás Cánepa
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Cell Death ◽  
Dna Damage Repair ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Damage Repair
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