scholarly journals The role of enterovirus 71 and coxsackievirus A strains in a large outbreak of hand, foot, and mouth disease in 2012 in Changsha, China

2014 ◽  
Vol 28 ◽  
pp. 17-25 ◽  
Author(s):  
Jing-Fang Chen ◽  
Ru-Sheng Zhang ◽  
Xin-Hua Ou ◽  
Fa-Ming Chen ◽  
Bian-Cheng Sun
Keyword(s):  
Enterovirus 71 ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Foot And Mouth ◽  
Large Outbreak

scholarly journals Increased Frequency of Circulating Follicular Helper T Cells in Children with Hand, Foot, and Mouth Disease Caused by Enterovirus 71 Infection

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Jianping Wu ◽  
David Cui ◽  
Xianzhi Yang ◽  
Jianzhou Lou ◽  
Jie Lin ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Enterovirus 71 ◽  
Foot And Mouth Disease ◽  
Serum Levels ◽  
Mouth Disease ◽  
Ev71 Infection ◽  
Tfh Cells ◽  
Follicular Helper ◽  
Foot And Mouth

Enterovirus 71 (EV71) is a major causative agent of hand, foot, and mouth disease (HFMD) in children. The role of T follicular helper (TFH) cells in EV71-infected children remains unclear in regulating humoral immunity. The frequency of circulating ICOShigh/PD-1highCXCR5+CD4+TFH cells in the children with mild and severe EV71 infection and healthy controls (HC) was detected by flow cytometry, respectively. IL-21 and IL-6 mRNA expression and their serum levels, Bcl-6 mRNA expression, and specific neutralizing antibodies against EV71 (NAb-EV71) were measured. In the acute stage of patients with EV71 infection, increased frequencies of circulating TFH cells with ICOShighand PD-1highexpression in the mild and severe patients were observed, and the positive correlations among the frequencies of circulating TFH cells and the serum levels of IL-21, IL-6, and NAb-EV71 titres were detected, respectively. Moreover, the expressions of IL-6 and IL-21 mRNA in PBMCs from patients were also significantly higher than those of HC. However, further analysis did not reveal any significant differences between mild and severe patients. These data indicate a role of TFH cells and associated cytokines in modulating the humoral response during the pathogenesis of EV71 infection.

scholarly journals A dynamic model for the outbreaks of hand, foot, and mouth disease in Taiwan

2015 ◽  
Vol 144 (7) ◽  
pp. 1500-1511 ◽  
Author(s):  
C.-C. LAI ◽  
D.-S. JIANG ◽  
H.-M. WU ◽  
H.-H. CHEN
Keyword(s):  
Infection Control ◽  
Enterovirus 71 ◽  
Foot And Mouth Disease ◽  
Control Policy ◽  
Mouth Disease ◽  
Basic Reproductive Number ◽  
Reproductive Number ◽  
Infection Control Policy ◽  
Foot And Mouth ◽  
Large Outbreak

SUMMARYThe first large outbreak of hand, foot, and mouth disease (HFMD) with severe complications primarily caused by enterovirus 71 was reported in Taiwan in 1998. Surveillance of HFMD to evaluate the spread of HFMD with and without infection control policy is needed. We developed a new dynamic epidemic Susceptible-Infected-Recovered (SIR) model to fit the surveillance data on containing valuable information on the severity of HFMD in order to accurately estimate the basic reproductive number (R0) of HFMD. After fitting the empirical data, in conjunction with other relevant parameters extracted from the literature, the estimated transmission coefficients were close to 5 × 10−7 (per day) and the proportion of severe HFMD cases ranged between 0 and 0·0036 (per day). Taking into account the distribution of all parameters considered in our dynamic epidemic model, the R0 computed was 1·37 (95% confidence interval 0·24–5·84), suggesting a higher likelihood of the spread of HFMD if no infection control policy is provided. The isolation strategy against the spread of HFMD not only delayed the epidemic peak with the delayed time ranging from 4 weeks for only 20% isolation to 47 weeks for 100% isolation but also reduced total number of HFMD cases with the percentage of reduction ranging from 1·3% for only 20% isolation to 13·3% for 100% isolation. The proposed model can also be flexible for evaluating the effectiveness of two other possible policies for containing HFMD, quarantine and vaccination (if the vaccine can be developed).

scholarly journals Doença mão-pé-boca no atendimento odontopediátrico

2020 ◽  
Vol 8 (12) ◽  
Author(s):  
Priscila Higa Nakao ◽  
Dalva Pereira Terra ◽  
Mario Eduardo Baldo ◽  
Ellen Cristina Gaetti Jardim
Keyword(s):  
Oral Cavity ◽  
Comparative Study ◽  
Viral Infections ◽  
Enterovirus 71 ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Coxsackie Virus ◽  
Pediatr Infect ◽  
Foot And Mouth

A doença mão-pé-boca é uma infecção viral, normalmente benigna que afeta comumente crianças até 10 anos, causada pelos enterovírus humano. O propósito deste estudo foi revisar os aspectos da doença que se faz presente nos dias atuais abordando a etiologia, epidemiologia, surtos, sintomatologia e comorbidades, diagnóstico, prevenção e tratamento. Foram selecionadas publicações em periódicos referenciados nas fontes de dados do Google Acadêmico, Pubmed e Periódicos Capes com as palavras chaves relacionadas ao tema desse trabalho como doença mão-pé-boca e crianças, sendo selecionados artigos produzidos até 2017. Apesar de diagnóstico clínico aparentemente simples, a doença pode ser confundida com outras enfermidades por suas características semelhantes, que podem induzir o colega odontólogo ao equívoco de diagnóstico.Descritores: Doença de Mão, Pé e Boca; Diagnóstico, Odontopediatria.ReferênciasSarkar PK, Sarker NK, Tayab A. Hand, foot and mouth disease (hfmd):an update. Bangladesh J Child Health. 2016;40(2):115-19.Sarma N. Hand, foot, and mouth disease: current scenario and Indian perspective. Indian J Dermatol Venereol Leprol. 2013;79(2):165-75.Fatahzadeh M. Oral manifestation of viral infections. Atlas Oral Maxillofac Surg Clin North Am. 2017;25(2):163-70.Nassef C, Ziemer C, Morrell DS. Hand-foot-and-mouth disease: a new look at a classic viral rash. Curr Opin Pediatr.  2015;27(4):486-91.Grinde B, Olsen I. The role of viroses in oral disease. J Oral Microbiol. 2010;2(1):1-6.Cepeda CO, Valverde AM, Recolons MMS, Salas EJ, Roig AM, López JL. A literature review and case reporto f hand, foot and mouth disease in na immunocompetent adult. BMC Res Notes. 2016;9:165.Robinson CR, Doane FW, Rhodes AJ. Report of an outbreak of febrile illness with pharyngeal lesions and exanthem: Toronto, Summer 1957- isolation of group A coxsackie virus. Can Med Assoc J. 1958;79(8):615-21.Alsop J, Flewett TH, Foster JR. Hand-foot-and-mouth disease” in Birmingham in 1959. Br Med J. 1960;2(5214):1708–11.Cristovam MAS, Osaku NO, Gabriel GFCP, Rodrigues SPSG, Pompeu CB, Pires TG. Síndrome mão-pé-boca: relato de caso. Rev Med Res. 2014;16(1):42-5.Repass GL, Palmer WC, Stancampiano FF. Hand, foot, and mouth disease: identifying and managing na acute viral syndrome. Cleve Clin J Med. 2014;81(9):537-43.Kashyap RR, Kashyap RS. Hand, foot and mouth disease- a short case report. J Clin Exp Dent. 2015;7(2):e336-38.Babu NA, Malathi L, Kasthuri M, Jimson S. Ulcerative lesions of the oral cavity - an overview. Biomed Pharmacol J. 2017;10(1):401-5.Xing W, Liao Z, Sun J, Wu J T, Chang Z, Liu F, et al. Hand, foot, and mouth disease in China, 2008–12: an epidemiological study. Lancet Infect Dis. 2014;14:308-18.Wu Y, Yeo A, Phoon MC, Tan EL, Poh CL, QuakSH et al.  The largest outbreak of hand; foot and mouth disease in Singapore in 2008: the role of enterovirus 71 and coxsackievirus A strains. Int J Infect Dis. 2010;14:e1076-81.Wang J, Hu T, Sun D, Ding S, Carr M, Xin W, et al. Epidemiological characteristics of hand, foot, and mouth disease in Shandong, China, 2009-2016. Sci Rep.2017;7(1):1-9.He SZ, Chen MY, Xu XR, Yan Q, Niu JJ, Wu WH et al. Epidemics and aetiology of hand, foot and mouth disease in Xiamen, China, from 2008 to 2015. Epidemiol Infect. 2017;145:1865-74.Dantas A, Oliveira MJ, Lourenço O, Coelho PB. Doença mão-pé-boca no adulto - a propósito de um caso clínico. Rev Port Med Geral Farm. 2013;29:62-5.Chatproedprai S, Theanboonlers A, Korkong S, Thongmee C, Wananukul S, Poovorawan. Clinical and molecular characterization of hand-foot-and-mouth disease in thailand, 2008-2009. J Infect Dis. 2010;63:229-233.Zhang W, Du Z, Zhang D, Yu S, Hao Y. Quantifying the adverse effect of excessive heat on children: an elevated risk of hand, foot and mouth disease in hot days. Sci Total Environ. 2016;541:194-99.Koh WM, Bogich T, Siegel K, Jin J, Chong EY, Tan CY et al. The epidemiology of hand, foot and mouth disease in Asia: a systematic review and analysis. Pediatr Infect Dis J. 2016;35(10):e285-300.Pham HV, Hoang TNA, Duong HT, Phan LT, Phan UTN, Ho NX et al. Clinical characteristics of hand, foot and mouth disease in Daklak Province, Vietnam and associated factors of severe cases. Virus Dis.2017;28(4):430-33.Lam JM.  Characterizing viral exanthems. Ped Health. 2010;4(6):623-35.World Health Organization: western Pacific Region. A guide to clinical management and public health response for hand, foot, and mouth disease (HFMD).Ganga N. Hand foot and mouth disease like illness in office practice. Indian J Pediatr. 2017; 84(3):216-18.Chang LY, Lin TY, Hung K, Huang YC, Lin KL, Hsueh C et al.Clinical features and risk factors of pulmonary oedema after en terovi rus-71-related hand, foot, and mouth disease. Lancet. 1999;354(9191):1682-86.Cabrol Y, Peah P, Mey C, Duong V, Richner B, Laurent D et al. A prospective, comparative study of severe neurological and uncomplicated hand, foot and mouth forms of paediatric enterovirus 71 infections. Int J Infect Dis. 2017;59:69-76.Alter SJ, Bennett JS, Koranyi K, Kreppel A, Simon R. Common childhood viral infections. Curr Probl Pediatr Adolesc Health Care. 2015;45:21-53.Li Y, Deng H, Li M, Wang W, Jia X, Gao N et al. Prolonged breastfeeding is associated with lower risk of severe hand, foot and mouth disease in chinese childre. Pediatr Infect Dis J. 2016;35(3):353-55.Wolf D, Otto J. Efficacy and safety of lidocaine gel in patients from 6 months up 8 years with acute painful sites in the oral cavity: a randomized, placebo-contolled, double-blind, comparative study. Int J Pediatr. 2015.2015:146717.

scholarly journals DNA methylation and SNP in IFITM3 are correlated with hand, foot and mouth disease caused by enterovirus 71

2021 ◽  
Vol 105 ◽  
pp. 199-208
Author(s):  
Mei Li ◽  
Ya-Ping Li ◽  
Hui-Ling Deng ◽  
Mu-Qi Wang ◽  
Yuan Chen ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Enterovirus 71 ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Foot And Mouth

scholarly journals Advances in Antigenic Peptide-Based Vaccine and Neutralizing Antibodies against Viruses Causing Hand, Foot, and Mouth Disease

2019 ◽  
Vol 20 (6) ◽  
pp. 1256 ◽  
Author(s):  
Mohd Anasir ◽  
Chit Poh
Keyword(s):  
Neutralizing Antibodies ◽  
Enterovirus 71 ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Antigenic Peptide ◽  
Effective Vaccine ◽  
Inactivated Vaccine ◽  
Antigenic Peptides ◽  
Foot And Mouth ◽  
Etiological Agents

Hand, foot, and mouth disease (HFMD) commonly produces herpangina, but fatal neurological complications have been observed in children. Enterovirus 71 (EV-A71) and Coxsackievirus 16 (CV-A16) are the predominant viruses causing HFMD worldwide. With rising concern about HFMD outbreaks, there is a need for an effective vaccine against EV-A71 and CV-A16. Although an inactivated vaccine has been developed against EV-A71 in China, the inability of the inactivated vaccine to confer protection against CV-A16 infection and other HFMD etiological agents, such as CV-A6 and CV-A10, necessitates the exploration of other vaccine platforms. Thus, the antigenic peptide-based vaccines are promising platforms to develop safe and efficacious multivalent vaccines, while the monoclonal antibodies are viable therapeutic and prophylactic agents against HFMD etiological agents. This article reviews the available information related to the antigenic peptides of the etiological agents of HFMD and their neutralizing antibodies that can provide a basis for the design of future therapies against HFMD etiological agents.

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