Viral kinetics of SARS-CoV-2 in asymptomatic carriers and presymptomatic patients

AbstractBackgroundAsymptomatic carriers contribute to the spread of Coronavirus Disease 2019 (COVID-19), but their clinical characteristics, viral kinetics, and antibody responses remain unclear.MethodsA total of 56 COVID-19 patients without symptoms at admission and 19 age-matched symptomatic patients were enrolled. RNA of SARS-CoV-2 was tested using transcriptase quantitative PCR, and the total antibodies (Ab), IgG, IgA and IgM against the SARS-CoV-2 were tested using Chemiluminescence Microparticle Immuno Assay.ResultsAmong 56 patients without symptoms at admission, 33 cases displayed symptoms and 23 remained asymptomatic throughout the follow-up period. 43.8% of the asymptomatic carriers were children and none of the asymptomatic cases had recognizable changes in C-reactive protein or interleukin-6, except one 64-year-old patient. The initial threshold cycle value of nasopharyngeal SARS-CoV-2 in asymptomatic carriers was similar to that in pre-symptomatic and symptomatic patients, but the communicable period of asymptomatic carriers (9.63 days) was shorter than pre-symptomatic patients (13.6 days). There was no obvious differences of the seropositive conversion rate of total Ab, IgG, and IgA among the three groups, though the rates of IgM varied largely. The average peak IgG and IgM COI of asymptomatic cases was 3.5 and 0.8, respectively, which is also lower than those in symptomatic patients with peaked IgG and IgM COI of 4.5 and 2.4 (p <0.05).ConclusionYoung COVID-19 patients seem to be asymptomatic cases with early clearance of SARS-CoV-2 and low levels of IgM generation but high total Ab, IgG and IgA. Our findings provide empirical information for viral clearance and antibody kinetics of asymptomatic COVID-19 patients.

Download Full-text

Early Viral Clearance and Antibody Kinetics of COVID-19 Among Asymptomatic Carriers

Frontiers in Medicine ◽

10.3389/fmed.2021.595773 ◽

2021 ◽

Vol 8 ◽

Author(s):

Tongyang Xiao ◽

Yanrong Wang ◽

Jing Yuan ◽

Haocheng Ye ◽

Lanlan Wei ◽

...

Keyword(s):

Viral Clearance ◽

Nucleic Acid Detection ◽

Viral Kinetics ◽

Asymptomatic Carriers ◽

Reactive Protein ◽

Low Levels ◽

Immuno Assay ◽

Antibody Kinetics ◽

Kinetics Of

Asymptomatic carriers contribute to the spread of Coronavirus Disease 2019 (COVID-19), but their clinical characteristics, viral kinetics, and antibody responses remain unclear. A total of 56 COVID-19 patients without symptoms at admission and 19 age-matched symptomatic patients were enrolled. RNA of SARS-CoV-2 was tested using transcriptase quantitative PCR, and the total antibodies (Ab), IgG, IgA, and IgM against the SARS-CoV-2 were tested using Chemiluminescence Microparticle Immuno Assay. Among 56 patients without symptoms at admission, 33 cases displayed symptoms and 23 remained asymptomatic throughout the follow-up period. 43.8% of the asymptomatic carriers were children and none of the asymptomatic cases had recognizable changes in C-reactive protein or interleukin-6, except one 64-year-old patient. The initial threshold cycle value of nasopharyngeal SARS-CoV-2 in asymptomatic carriers was similar to that in pre-symptomatic and symptomatic patients, but the positive viral nucleic acid detection period of asymptomatic carriers (9.63 days) was shorter than pre-symptomatic patients (13.6 days). There were no obvious differences in the seropositive conversion rate of total Ab, IgG, and IgA among the three groups, though the rates of IgM varied largely. The average peak IgG and IgM COI of asymptomatic cases was 3.5 and 0.8, respectively, which is also lower than those in symptomatic patients with peaked IgG and IgM COI of 4.5 and 2.4 (p < 0.05). Young COVID-19 patients seem to be asymptomatic cases with early clearance of SARS-CoV-2 and low levels of IgM generation but high total Ab, IgG, and IgA. Our findings provide empirical information for viral clearance and antibody kinetics of asymptomatic COVID-19 patients.

Download Full-text

Viral Kinetics of SARS-CoV-2 Over the Preclinical, Clinical and Postclinical Period

SSRN Electronic Journal ◽

10.2139/ssrn.3590470 ◽

2020 ◽

Author(s):

Sukbin Jang ◽

Ji-Young Rhee ◽

Bo Kyeung Jung

Keyword(s):

Viral Kinetics ◽

Kinetics Of

Download Full-text

Mathematical analysis of a within-host model of SARS-CoV-2

Advances in Difference Equations ◽

10.1186/s13662-021-03276-1 ◽

2021 ◽

Vol 2021 (1) ◽

Author(s):

Bhagya Jyoti Nath ◽

Kaushik Dehingia ◽

Vishnu Narayan Mishra ◽

Yu-Ming Chu ◽

Hemanta Kumar Sarmah

Keyword(s):

Stability Analysis ◽

Basic Reproduction Number ◽

Reproduction Number ◽

Basic Reproduction Ratio ◽

Viral Kinetics ◽

Reproduction Ratio ◽

Biological Implication ◽

Infection Models ◽

Kinetics Of ◽

The Basic Reproduction Number

AbstractIn this paper, we have mathematically analyzed a within-host model of SARS-CoV-2 which is used by Li et al. in the paper “The within-host viral kinetics of SARS-CoV-2” published in (Math. Biosci. Eng. 17(4):2853–2861, 2020). Important properties of the model, like nonnegativity of solutions and their boundedness, are established. Also, we have calculated the basic reproduction number which is an important parameter in the infection models. From stability analysis of the model, it is found that stability of the biologically feasible steady states are determined by the basic reproduction number $(\chi _{0})$ ( χ 0 ) . Numerical simulations are done in order to substantiate analytical results. A biological implication from this study is that a COVID-19 patient with less than one basic reproduction ratio can automatically recover from the infection.

Download Full-text

Sa056 VIRAL KINETICS OF A HASHTAG: SOCIAL MEDIA ENGAGEMENT OF MAJOR GASTROENTEROLOGY AND HEPATOLOGY CONFERENCES DURING THE COVID-19 PANDEMIC

Gastroenterology ◽

10.1016/s0016-5085(21)01669-3 ◽

2021 ◽

Vol 160 (6) ◽

pp. S-401

Author(s):

Bilal A. Asif ◽

Christopher Koh

Keyword(s):

Social Media ◽

Viral Kinetics ◽

Social Media Engagement ◽

Kinetics Of

Download Full-text

Simulation Model for Dynamics of Dengue with Innate and Humoral Immune Responses

Computational and Mathematical Methods in Medicine ◽

10.1155/2018/8798057 ◽

2018 ◽

Vol 2018 ◽

pp. 1-18 ◽

Cited By ~ 3

Author(s):

S. D. Perera ◽

S. S. N. Perera

Keyword(s):

Immune Response ◽

Immune Responses ◽

Dengue Virus ◽

Dengue Infection ◽

Asymptomatic Infection ◽

Severe Dengue ◽

Viral Kinetics ◽

Humoral Immune ◽

Humoral Immune Responses ◽

Kinetics Of

Dengue virus is a mosquito borne Flavivirus and the most prevalent arbovirus in tropical and subtropical regions around the world. The incidence of dengue has increased drastically over the last few years at an alarming rate. The clinical manifestation of dengue ranges from asymptomatic infection to severe dengue. Even though the viral kinetics of dengue infection is lacking, innate immune response and humoral immune response are thought to play a major role in controlling the virus count. Here, we developed a computer simulation mathematical model including both innate and adaptive immune responses to study the within-host dynamics of dengue virus infection. A sensitivity analysis was carried out to identify key parameters that would contribute towards severe dengue. A detailed stability analysis was carried out to identify relevant range of parameters that contributes to different outcomes of the infection. This study provides a qualitative understanding of the biological factors that can explain the viral kinetics during a dengue infection.

Download Full-text