scholarly journals Mathematical analysis of a within-host model of SARS-CoV-2

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Bhagya Jyoti Nath ◽  
Kaushik Dehingia ◽  
Vishnu Narayan Mishra ◽  
Yu-Ming Chu ◽  
Hemanta Kumar Sarmah
Keyword(s):  
Stability Analysis ◽  
Basic Reproduction Number ◽  
Reproduction Number ◽  
Basic Reproduction Ratio ◽  
Viral Kinetics ◽  
Reproduction Ratio ◽  
Biological Implication ◽  
Infection Models ◽  
Kinetics Of ◽  
The Basic Reproduction Number

AbstractIn this paper, we have mathematically analyzed a within-host model of SARS-CoV-2 which is used by Li et al. in the paper “The within-host viral kinetics of SARS-CoV-2” published in (Math. Biosci. Eng. 17(4):2853–2861, 2020). Important properties of the model, like nonnegativity of solutions and their boundedness, are established. Also, we have calculated the basic reproduction number which is an important parameter in the infection models. From stability analysis of the model, it is found that stability of the biologically feasible steady states are determined by the basic reproduction number $(\chi _{0})$ ( χ 0 ) . Numerical simulations are done in order to substantiate analytical results. A biological implication from this study is that a COVID-19 patient with less than one basic reproduction ratio can automatically recover from the infection.

scholarly journals Local Dynamics of an SVIR Epidemic Model with Logistic Growth

CAUCHY ◽  
2020 ◽  
Vol 6 (3) ◽  
pp. 122-132
Author(s):  
Joko Harianto ◽  
Inda Puspita Sari
Keyword(s):  
Stability Analysis ◽  
Equilibrium Point ◽  
Basic Reproduction Number ◽  
Local Stability ◽  
Reproduction Number ◽  
Endemic Equilibrium ◽  
Logistic Growth ◽  
Asymptotically Stable ◽  
Local Stability Analysis ◽  
The Basic Reproduction Number

Discussion of local stability analysis of SVIR models in this article is included in the scope of applied mathematics. The purpose of this discussion was to provide results of local stability analysis that had not been discussed in some articles related to the SVIR model. The SVIR models discussed in this article involve logistics growth in the vaccinated compartment. The results obtained, i.e. if the basic reproduction number less than one and m is positive, then there is one equilibrium point i.e. E0 is locally asymptotically stable. In the field of epidemiology, this means that the disease will disappear from the population. However, if the basic reproduction number more than one and b1 more than b, then there are two equilibrium points i.e. disease-free equilibrium point denoted by E0 and the endemic equilibrium point denoted by E1*. In this case the endemic equilibrium point E1* is locally asymptotically stable. In the field of epidemiology, this means that the disease will remain in the population. The numerical simulation supports these results.

scholarly journals Mathematical Assessment of the Dynamical Model of Smoking Tobacco Epidemic in Bangladesh

2020 ◽  
pp. 36-48
Author(s):  
Sk. Abdus Samad ◽  
Md. Tusberul Islam ◽  
Sayed Toufiq Hossain Tomal ◽  
MHA Biswas
Keyword(s):  
Numerical Simulation ◽  
Mathematical Model ◽  
Stability Analysis ◽  
Differential Equations ◽  
Basic Reproduction Number ◽  
Conversion Rate ◽  
Reproduction Number ◽  
The World ◽  
Tobacco Epidemic ◽  
The Basic Reproduction Number

Bangladesh is one of the largest tobacco users in the world being troubled by smoking related issues. In this paper we consider a compartmental mathematical model of smoking in which the population is divided into five compartments: susceptible, expose, smokers, temporary quitters and permanent quitters described by ordinary differential equations. We study by including the conversion rate from light smoker to permanent quit smokers. The basic reproduction number R0 has been derived and then we found two euilibria of the model one of them is smoking-free and other of them is smoking-present. We establish the positivity, boundedness of the solutions and perform stability analysis of the model. To decrease the smoking propensity in Bangladesh we perform numerical simulation for various estimations of parameters which offer understanding to give up smoking and how they influence the smoker and exposed class. This model gives us legitimate thought regarding the explanations for the spread of smoking in Bangladesh.

scholarly journals Dynamics model analysis of bacteriophage infection of bacteria

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Xiaoping Li ◽  
Rong Huang ◽  
Minyuan He
Keyword(s):  
Stability Analysis ◽  
Basic Reproduction Number ◽  
Jacobian Matrix ◽  
Reproduction Number ◽  
Host Density ◽  
Dynamics Model ◽  
Global Stability Analysis ◽  
Bacteriophage Infection ◽  
Host Parasite ◽  
The Basic Reproduction Number

AbstractA bacteriophage (in short, phage) is a virus that can infect and replicate within bacteria. Assuming that uninfected and infected bacteria are capable of reproducing with logistic law, we investigate a model of bacteriophage infection that resembles simple SI-models widely used in epidemiology. The dynamics of host-parasite co-extinctions may exhibit four scenarios: hosts and parasites go extinct, parasites go extinct, hosts go extinct, and hosts and parasites coexist. By using the Jacobian matrix and Bendixson–Dulac theory, local and global stability analysis of uninfected and infected steady states is provided; the basic reproduction number of the model is given; general results are supported by numerical simulations. We show that bacteriophages can reduce a host density. This provides a theoretical framework for studying the problem of whether phages can effectively prevent, control, and treat infectious diseases.

scholarly journals An SEIV Epidemic Model for Childhood Diseases with Partial Permanent Immunity

2015 ◽  
Vol 2015 ◽  
pp. 1-13
Author(s):  
Mei Bai ◽  
Lishun Ren
Keyword(s):  
Stability Analysis ◽  
Basic Reproduction Number ◽  
Epidemic Model ◽  
Reproduction Number ◽  
Critical Value ◽  
Global Asymptotical Stability ◽  
Bifurcation Parameter ◽  
Childhood Diseases ◽  
Childhood Disease ◽  
The Basic Reproduction Number

An SEIV epidemic model for childhood disease with partial permanent immunity is studied. The basic reproduction numberR0has been worked out. The local and global asymptotical stability analysis of the equilibria are performed, respectively. Furthermore, if we take the treated rateτas the bifurcation parameter, periodic orbits will bifurcate from endemic equilibrium whenτpasses through a critical value. Finally, some numerical simulations are given to support our analytic results.

scholarly journals Stability analysis of a smoking behavior model

2021 ◽  
Vol 2106 (1) ◽  
pp. 012025
Author(s):  
S M Lestari ◽  
Y Yulida ◽  
A S Lestia ◽  
M A Karim
Keyword(s):  
Mathematical Model ◽  
Stability Analysis ◽  
Equilibrium Point ◽  
Basic Reproduction Number ◽  
Reproduction Number ◽  
Smoking Behavior ◽  
Asymptotically Stable ◽  
Runge Kutta Method ◽  
The Stability ◽  
The Basic Reproduction Number

Abstract This research discussed the mathematical model of smoking behavior. The model will be analogous to an epidemic model which will be divided into several compartments/groups. This research aimed to explain the formation of a mathematical model of smoking behavior, to investigate the equilibrium point, the value of the basic reproduction number, to analyze the stability of the model, then to determine and interpret the numerical solutions using the fourth-order Runge-Kutta method. By the results of this research, a mathematical model of smoking behavior which consists of three compartments, namely the population of non-smokers, smokers and ex-smokers, was obtained. Based on the model formed the smoke-free equilibrium point and the smoker equilibrium point, then the basic reproduction number was also obtained using the next generation matrix. Furthermore, the result of the stability analysis of the smoker-free population was asymptotically stable provided that the basic reproduction number is less than one, while the population was asymptotically stable provided that the basic reproduction number is greater than one. The simulation of the model was presented to support the explanation of the stability analysis of the model using the fourth-order Runge-Kutta method based on the parameters that met the requirements of the stability analysis.

scholarly journals Local Stability Analysis of an SVIR Epidemic Model

CAUCHY ◽  
2017 ◽  
Vol 5 (1) ◽  
pp. 20
Author(s):  
Joko Harianto
Keyword(s):  
Stability Analysis ◽  
Basic Reproduction Number ◽  
Epidemic Model ◽  
Local Stability ◽  
Reproduction Number ◽  
Endemic Equilibrium ◽  
System Disease ◽  
Local Stability Analysis ◽  
Disease Free ◽  
The Basic Reproduction Number

In this paper, we present an SVIR epidemic model with deadly deseases. Initially the basic formulation of the model is presented. Two equilibrium point exists for the system; disease free and endemic equilibrium. The local stability of the disease free and endemic equilibrium exists when the basic reproduction number less or greater than unity, respectively. If the value of R0 less than one then the desease free equilibrium is locally stable, and if its exceeds, the endemic equilibrium is locally stable. The numerical results are presented for illustration.

scholarly journals Modeling the Transmission Dynamics of Measles in the Presence of Treatment as Control Strategy

2021 ◽  
pp. 76-86
Author(s):  
Rose Veronica Paul ◽  
William Atokolo ◽  
Salawu Ademu Saka ◽  
Achonu Omale Joseph
Keyword(s):  
Stability Analysis ◽  
Equilibrium Point ◽  
Basic Reproduction Number ◽  
Reproduction Number ◽  
Model Simulation ◽  
Research Work ◽  
Intervention Strategy ◽  
Transmission Dynamics ◽  
Disease Free ◽  
The Basic Reproduction Number

We present in this research work, mathematical modeling of the transmission dynamics of measles using treatment as a control measure. We determined the Disease Free Equilibrium (DFE) point of the model after which we obtained the Basic Reproduction Number ( R0 ) of the model using the next generation approach. The model Endemic Equilibrium (EE) point was also determined after which we performed Local Stability Analysis(LAS) of the Disease Free Equilibrium point and result shows that the Disease Free Equilibrium point of the model would be stable if ( R0 <1). Global Stability Analysis (GAS) result shows that, ( R0 ≤ 1) remains the necessary and sufficient condition for the infection to go into extinction from a population. We carried out Sensitivity Analysis of the model using the Basic Reproduction Number and we discovered that ( δ , μ, ν , θ ) are sensitive parameters that should be targeted towards control intervention strategy as an increase in these values can reduce the value of ( R0 ) to a value less than unity and such can reduce the spread of measles in a population. Model simulation was carried out using mat lab software to support our analytical results.

scholarly journals Fractional SIR-Model for Estimating Transmission Dynamics of COVID-19 in India

J ◽  
2021 ◽  
Vol 4 (2) ◽  
pp. 86-100
Author(s):  
Nita H. Shah ◽  
Ankush H. Suthar ◽  
Ekta N. Jayswal ◽  
Ankit Sikarwar
Keyword(s):  
Basic Reproduction Number ◽  
Reproduction Number ◽  
Transmission Rate ◽  
Sir Model ◽  
Time Dependent ◽  
Contact Rate ◽  
Distribution Maps ◽  
Fundamental Parameters ◽  
Different Order ◽  
The Basic Reproduction Number

In this article, a time-dependent susceptible-infected-recovered (SIR) model is constructed to investigate the transmission rate of COVID-19 in various regions of India. The model included the fundamental parameters on which the transmission rate of the infection is dependent, like the population density, contact rate, recovery rate, and intensity of the infection in the respective region. Looking at the great diversity in different geographic locations in India, we determined to calculate the basic reproduction number for all Indian districts based on the COVID-19 data till 7 July 2020. By preparing district-wise spatial distribution maps with the help of ArcGIS 10.2, the model was employed to show the effect of complete lockdown on the transmission rate of the COVID-19 infection in Indian districts. Moreover, with the model's transformation to the fractional ordered dynamical system, we found that the nature of the proposed SIR model is different for the different order of the systems. The sensitivity analysis of the basic reproduction number is done graphically which forecasts the change in the transmission rate of COVID-19 infection with change in different parameters. In the numerical simulation section, oscillations and variations in the model compartments are shown for two different situations, with and without lockdown.

scholarly journals Impact of early detection and vaccination strategy in COVID-19 eradication program in Jakarta, Indonesia

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Dipo Aldila ◽  
Brenda M. Samiadji ◽  
Gracia M. Simorangkir ◽  
Sarbaz H. A. Khosnaw ◽  
Muhammad Shahzad
Keyword(s):  
Mathematical Model ◽  
Basic Reproduction Number ◽  
Reproduction Number ◽  
Vaccination Strategy ◽  
Vaccination Rate ◽  
Rapid Testing ◽  
Social Distancing ◽  
Rapid Spread ◽  
Vaccine Potential ◽  
The Basic Reproduction Number

Abstract Objective Several essential factors have played a crucial role in the spreading mechanism of COVID-19 (Coronavirus disease 2019) in the human population. These factors include undetected cases, asymptomatic cases, and several non-pharmaceutical interventions. Because of the rapid spread of COVID-19 worldwide, understanding the significance of these factors is crucial in determining whether COVID-19 will be eradicated or persist in the population. Hence, in this study, we establish a new mathematical model to predict the spread of COVID-19 considering mentioned factors. Results Infection detection and vaccination have the potential to eradicate COVID-19 from Jakarta. From the sensitivity analysis, we find that rapid testing is crucial in reducing the basic reproduction number when COVID-19 is endemic in the population rather than contact trace. Furthermore, our results indicate that a vaccination strategy has the potential to relax social distancing rules, while maintaining the basic reproduction number at the minimum possible, and also eradicate COVID-19 from the population with a higher vaccination rate. In conclusion, our model proposed a mathematical model that can be used by Jakarta’s government to relax social distancing policy by relying on future COVID-19 vaccine potential.

scholarly journals Mathematical analysis of a measles transmission dynamics model in Bangladesh with double dose vaccination

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Md Abdul Kuddus ◽  
M. Mohiuddin ◽  
Azizur Rahman
Keyword(s):  
Basic Reproduction Number ◽  
Reproduction Number ◽  
Transmission Rate ◽  
Equilibrium Points ◽  
Rank Correlation ◽  
Dynamical Analysis ◽  
Model Parameters ◽  
Progression Rate ◽  
Double Dose ◽  
The Basic Reproduction Number

AbstractAlthough the availability of the measles vaccine, it is still epidemic in many countries globally, including Bangladesh. Eradication of measles needs to keep the basic reproduction number less than one $$(\mathrm{i}.\mathrm{e}. \, \, {\mathrm{R}}_{0}<1)$$ ( i . e . R 0 < 1 ) . This paper investigates a modified (SVEIR) measles compartmental model with double dose vaccination in Bangladesh to simulate the measles prevalence. We perform a dynamical analysis of the resulting system and find that the model contains two equilibrium points: a disease-free equilibrium and an endemic equilibrium. The disease will be died out if the basic reproduction number is less than one $$(\mathrm{i}.\mathrm{e}. \, \, {\mathrm{ R}}_{0}<1)$$ ( i . e . R 0 < 1 ) , and if greater than one $$(\mathrm{i}.\mathrm{e}. \, \, {\mathrm{R}}_{0}>1)$$ ( i . e . R 0 > 1 ) epidemic occurs. While using the Routh-Hurwitz criteria, the equilibria are found to be locally asymptotically stable under the former condition on $${\mathrm{R}}_{0}$$ R 0 . The partial rank correlation coefficients (PRCCs), a global sensitivity analysis method is used to compute $${\mathrm{R}}_{0}$$ R 0 and measles prevalence $$\left({\mathrm{I}}^{*}\right)$$ I ∗ with respect to the estimated and fitted model parameters. We found that the transmission rate $$(\upbeta )$$ ( β ) had the most significant influence on measles prevalence. Numerical simulations were carried out to commissions our analytical outcomes. These findings show that how progression rate, transmission rate and double dose vaccination rate affect the dynamics of measles prevalence. The information that we generate from this study may help government and public health professionals in making strategies to deal with the omissions of a measles outbreak and thus control and prevent an epidemic in Bangladesh.

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