The scientific and clinical need to advance understanding of the processes related to Hispanic acculturation and its impacts is pressing. This chapter articulates how acculturation stress and related specific stressor events occur within distinct life domains or contexts. New research is juxtaposed to previous research that demonstrated how acculturation stressors cluster in unique, orthogonal, and independent life domains among both adult and adolescent Hispanics. This chapter refers to contexts of acculturation stress as spheres of life or domains that entail social and psychological interactions with the dominant, receiving culture. New research is presented on the relationship between acculturation stress context among adult Hispanics and mental health indicators. Understanding the contexts in which acculturation-related stress can impact Latinos is critical to health and behavioral health programming, where such information can assist in the development, adaptation, and tailoring of prevention and interventions that are more acceptable and relevant for this growing population.