Primary sequence determination of a monoclonal antibody against α-synuclein using a novel mass spectrometry-based approach

2012 ◽  
Vol 312 ◽  
pp. 61-69 ◽  
Author(s):  
Eric Sousa ◽  
Stephane Olland ◽  
Heather H. Shih ◽  
Kim Marquette ◽  
Robert Martone ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Monoclonal Antibody ◽  
Primary Sequence ◽  
Sequence Determination

Primary sequence determination of a Kunitz inhibitor isolated from Delonix regia seeds

2001 ◽  
Vol 57 (5) ◽  
pp. 625-631 ◽  
Author(s):  
Silvana C Pando ◽  
Maria L.V Oliva ◽  
Claudio A.M Sampaio ◽  
Luciana Di Ciero ◽  
José C Novello ◽  
...  
Keyword(s):  
Primary Sequence ◽  
Sequence Determination ◽  
Delonix Regia ◽  
Kunitz Inhibitor

Tandem mass spectrometry methodology for the sequence determination of cyclic peptides

1985 ◽  
Vol 107 (24) ◽  
pp. 6765-6769 ◽  
Author(s):  
Klaus Eckart ◽  
Helmut Schwarz ◽  
Kenneth B. Tomer ◽  
Michael L. Gross
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Cyclic Peptides ◽  
Tandem Mass ◽  
Sequence Determination

scholarly journals The separation and sequencing of permethylated peptides by mass spectrometry directly coupled to gas-liquid chromatography

1976 ◽  
Vol 157 (3) ◽  
pp. 777-780 ◽  
Author(s):  
J D Priddle ◽  
K Rose ◽  
R E Offord
Keyword(s):  
Mass Spectrometry ◽  
Molecular Weight ◽  
Chemical Ionization ◽  
Chromatographic Retention ◽  
Gas Liquid Chromatography ◽  
Retention Data ◽  
Primary Sequence ◽  
Peptide Derivatives ◽  
Derivatives Of

The use of g.l.c. coupled to mass spectrometry to separate and sequence permethylated acetyl- and trifluoroacetyl-peptides in a single operation is described. Both electron impact and chemical ionization were used to induce fragmentation, and the latter was found to be more sensitive. Chromatographic retention data are presented which suggest that peptide derivatives of molecular weight of at least 750 are accessible to the technique. The application of our methods to the determination of the primary sequence of proteins is discussed.

Sequence determination of unknown cyclic peptide antibiotics by fast atom bombardment mass spectrometry

1990 ◽  
Vol 19 (7) ◽  
pp. 395-399 ◽  
Author(s):  
K. Ishikawa ◽  
Y. Niwa ◽  
K. Oishi ◽  
S. Aoi ◽  
T. Takeuchi ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Fast Atom Bombardment ◽  
Cyclic Peptide ◽  
Peptide Antibiotics ◽  
Sequence Determination
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