Acceptability and feasibility of a public square dancing for community senior citizens with mild cognitive impairment and depressive symptoms: A pilot study

ABSTRACTObjective:There is increasing evidence of an association between depressive symptoms and mild cognitive impairment (MCI) in cross-sectional studies, but the longitudinal association between depressive symptoms and risk of MCI onset is less clear. The authors investigated whether baseline symptom severity of depression was predictive of time to onset of symptoms of MCI.Method:These analyses included 300 participants from the BIOCARD study, a cohort of individuals who were cognitively normal at baseline (mean age = 57.4 years) and followed for up to 20 years (mean follow-up = 2.5 years). Depression symptom severity was measured using the Hamilton Depression Scale (HAM-D). The authors assessed the association between dichotomous and continuous HAM-D and time to onset of MCI within 7 years versus after 7 years from baseline (reflecting the mean time from baseline to onset of clinical symptoms in the cohort) using Cox regression models adjusted for gender, age, and education.Results:At baseline, subjects had a mean HAM-D score of 2.2 (SD = 2.8). Higher baseline HAM-D scores were associated with an increased risk of progression from normal cognition to clinical symptom onset ≤ 7 years from baseline (p= 0.043), but not with progression > 7 years from baseline (p= 0.194). These findings remained significant after adjustment for baseline cognition.Conclusions:These results suggest that low levels of depressive symptoms may be predictive of clinical symptom onset within approximately 7 years among cognitively normal individuals and may be useful in identifying persons at risk for MCI due to Alzheimer’s disease.

Download Full-text

Mindfulness and psychoeducation to manage stress in amnestic mild cognitive impairment: A pilot study

Aging & Mental Health ◽

10.1080/13607863.2018.1484890 ◽

2018 ◽

Vol 23 (9) ◽

pp. 1246-1254 ◽

Cited By ~ 2

Author(s):

Anne-Marie Chouinard ◽

Eddy Larouche ◽

Marie-Claude Audet ◽

Carol Hudon ◽

Sonia Goulet

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Pilot Study ◽

Amnestic Mild Cognitive Impairment

Download Full-text

IC-P-012: Subtypes of mild cognitive impairment differentiated based on limbic white matter integrity and cortical glucose metabolism: A pilot study using DTI and FDG-PET

Alzheimer s & Dementia ◽

10.1016/j.jalz.2010.05.027 ◽

2010 ◽

Vol 6 ◽

pp. S10-S10 ◽

Cited By ~ 1

Author(s):

Igor O. Korolev ◽

Lori A. Hoisington ◽

Kevin L. Berger ◽

Andrea C. Bozoki

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

White Matter ◽

Pilot Study ◽

Glucose Metabolism ◽

Fdg Pet ◽

White Matter Integrity

Download Full-text

Abstract 14215: Cognitive Impairment in Adult Congenital Heart Disease Survivors: A Pilot Study

Circulation ◽

10.1161/circ.142.suppl_3.14215 ◽

2020 ◽

Vol 142 (Suppl_3) ◽

Author(s):

Carla P Rodriguez Monserrate ◽

Rajeshwari Jakkam ◽

Emily Clay ◽

Kimberlee Gauvreau ◽

Michelle Z GURVITZ

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Pilot Study ◽

General Population ◽

Ventricular Function ◽

Congenital Heart ◽

Education Level ◽

Factors Associated

Introduction: The most common comorbidities in children with congenital heart disease (CHD) are neurodevelopmental and psychosocial impairments, particularly in areas of executive function, memory, attention, and behavioral control. Limited studies in the adult CHD population suggest similar impairments exist and adults with CHD may be at increased risk for dementia. No studies have screened specifically for mild cognitive impairment and dementia in adult CHD patients. Methods: We performed a prospective cross-sectional study of adult CHD patients, ages 30-65 years, who were coming for routine clinic visits. We administered the Mini-Mental State Exam (MMSE) and scores were compared with population norms adjusted by age and education level. We also evaluated the association of MMSE scores with CHD complexity, demographic and clinical risk factors. Results: A total of 125 patients were recruited (55% male). The median age was 40 years (range 30-65). Almost all participants (97%) had a high school degree and 75% had some college education or advanced degrees. The majority of patients (94%) had moderate or complex CHD. Adjusting for age and education, CHD participants scored significantly lower than the general population (median 1 point lower, p=0.001). The greatest impairments occurred in recall and orientation. Factors associated with lower scores included decreased systemic ventricular function (p=0.028) and having ≥2 cardiac catheterizations (p=0.006). Five percent of the total cohort met the general threshold for mild cognitive impairment (MMSE<24). Clinical factors associated with this degree of cognitive impairment were duration of cyanosis (p=0.005) and decreased systemic ventricular function (p=0.003). Conclusions: Our pilot study showed that, when adjusted for age and education level, adult CHD patients had significantly lower MMSE scores than the general population, with 5% meeting criteria for mild cognitive impairment. These findings suggest that subtle and early neurodevelopmental changes are present in the adult CHD population. Further studies are needed to investigate those changes and evaluate potential disease modifying therapies that might influence long-term outcomes in the adult CHD population.

Download Full-text