Quality by design: Understanding the formulation variables of a cyclosporine A self-nanoemulsified drug delivery systems by Box–Behnken design and desirability function

2007 ◽  
Vol 332 (1-2) ◽  
pp. 55-63 ◽  
Author(s):  
Ahmed S. Zidan ◽  
Omaima A. Sammour ◽  
Mohammed A. Hammad ◽  
Nagia A. Megrab ◽  
Muhammad J. Habib ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cyclosporine A ◽  
Drug Delivery Systems ◽  
Quality By Design ◽  
Desirability Function ◽  
Delivery Systems ◽  
Box Behnken Design ◽  
Formulation Variables

‘Quality by Design’ Approach for Development of Multiparticulate Drug Delivery Systems

2019 ◽  
pp. 351-365 ◽  
Author(s):  
Md Saquib Hasnain ◽  
Syed Anees Ahmed ◽  
Sarwar Beg ◽  
Mohammad Tahir Ansari ◽  
Amit Kumar Nayak
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Quality By Design ◽  
Delivery Systems ◽  
Design Approach ◽  
Quality By Design Approach

scholarly journals Optimization of Rifapentine-Loaded Lipid Nanoparticles Using a Quality-by-Design Strategy

Pharmaceutics ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 75 ◽  
Author(s):  
Joana Magalhães ◽  
Luise L. Chaves ◽  
Alexandre C. Vieira ◽  
Susana G. Santos ◽  
Marina Pinheiro ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Quality By Design ◽  
Lipid Nanoparticles ◽  
Delivery Systems ◽  
Human Macrophage ◽  
Scanning Calorimetry ◽  
Transmission Electron Microscopy Analysis ◽  
Electron Microscopy Analysis ◽  
Quality By Design Approach

This work aims to optimize and assess the potential use of lipid nanoparticles, namely nanostructured lipid carriers (NLCs), as drug delivery systems of rifapentine (RPT) for the treatment of tuberculosis (TB). A Box–Behnken design was used to increase drug encapsulation efficiency (EE) and loading capacity (LC) of RPT-loaded NLCs. The optimized nanoparticles were fully characterized, and their effect on cell viability was assessed. The quality-by-design approach allowed the optimization of RPT-loaded NLCs with improved EE and LC using the minimum of experiments. Analyses of variance were indicative of the validity of this model to optimize this nanodelivery system. The optimized NLCs had a mean diameter of 242 ± 9 nm, polydispersity index <0.2, and a highly negative zeta potential. EE values were higher than 80%, and differential scanning calorimetry analysis enabled the confirmation of the efficient encapsulation of RPT. Transmission electron microscopy analysis showed spherical nanoparticles, uniform in shape and diameter, with no visible aggregation. Stability studies indicated that NLCs were stable over time. No toxicity was observed in primary human macrophage viability for nanoparticles up to 1000 μg mL−1. Overall, the optimized NLCs are efficient carriers of RPT and should be considered for further testing as promising drug delivery systems to be used in TB treatment.

Formulation by design of felodipine loaded liquid and solid self nanoemulsifying drug delivery systems using Box–Behnken design

2013 ◽  
Vol 40 (10) ◽  
pp. 1358-1370 ◽  
Author(s):  
Samridhi Verma ◽  
Sandeep Kumar Singh ◽  
Priya Ranjan Prasad Verma ◽  
Mohd Neyaz Ahsan
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Box Behnken Design

Quality by design: Characterization of self-nano-emulsified drug delivery systems (SNEDDs) using ultrasonic resonator technology

2007 ◽  
Vol 341 (1-2) ◽  
pp. 189-194 ◽  
Author(s):  
R.B. Shah ◽  
A.S. Zidan ◽  
T. Funck ◽  
M.A. Tawakkul ◽  
A. Nguyenpho ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Quality By Design ◽  
Delivery Systems
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