Quality by design (QbD) approach of pharmacogenomics in drug designing and formulation development for optimization of drug delivery systems

2017 ◽  
Vol 245 ◽  
pp. 15-26 ◽  
Author(s):  
Sumeet Gupta ◽  
Vikas Jhawat
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Quality By Design ◽  
Delivery Systems ◽  
Formulation Development ◽  
Drug Designing

Formulation, Development and Characterization of Floating Beads of Diltiazem Hydrochloride

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Anamika Saxena Saxena ◽  
Santosh Kitawat ◽  
Kalpesh Gaur ◽  
Virendra Singh
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Entrapment Efficiency ◽  
Repeated Administration ◽  
Alginate Beads ◽  
Delivery Systems ◽  
Sem Analysis ◽  
Formulation Development

The main goal of any drug delivery system is to achieve desired concentration of the drug in blood or tissue, which is therapeutically effective and nontoxic for a prolonged period. Various attempts have been made to develop gastroretentive delivery systems such as high density system, swelling, floating system. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. Gastric emptying is a complex process and makes in vivo performance of the drug delivery systems uncertain. In order to avoid this variability, efforts have been made to increase the retention time of the drug-delivery systems for more than 12 hours. The floating or hydrodynamically controlled drug delivery systems are useful in such application. Background of the research: Diltiazem HCL (DTZ), has short biological half life of 3-4 h, requires rather high frequency of administration. Due to repeated administration there may be chances of patient incompliance and toxicity problems. Objective: The objective of study was to develop sustained release alginate beads of DTZ for reduction in dosing frequency, high bioavailability and better patient compliance. Methodology: Five formulations prepared by using different drug to polymer ratios, were evaluated for relevant parameters and compared. Alginate beads were prepared by ionotropic external gelation technique using CaCl2 as cross linking agent. Prepared beads were evaluated for % yield, entrapment efficiency, swelling index in 0.1N HCL, drug release study and SEM analysis. In order to improve %EE and drug release, LMP and sunflower oil were used as copolymers along with sodium alginate.

‘Quality by Design’ Approach for Development of Multiparticulate Drug Delivery Systems

2019 ◽  
pp. 351-365 ◽  
Author(s):  
Md Saquib Hasnain ◽  
Syed Anees Ahmed ◽  
Sarwar Beg ◽  
Mohammad Tahir Ansari ◽  
Amit Kumar Nayak
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Quality By Design ◽  
Delivery Systems ◽  
Design Approach ◽  
Quality By Design Approach

Exploring Novel Strategies for Lipid-Based Drug Delivery

2018 ◽  
Vol 3 (1) ◽  
pp. 1-22
Author(s):  
Sabna Kotta ◽  
Navneet Sharma ◽  
Prateek Raturi ◽  
Mohd Aleem ◽  
Rakesh Kumar Sharma
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Classification Scheme ◽  
Delivery Systems ◽  
Primary Objective ◽  
Formulation Development ◽  
The Common ◽  
Do So

Currently, the concept of lipid-based drug delivery systems has gained much interest because of their capability to deliver drugs which dissolve sparingly in water or insoluble in nature. Several methods of lipid-based drug delivery exist, and each method has its own advantages as well as limitations. The primary objective of the formulation development is to improve the bioavailability of the drug. The nano-sized lipid-based drug delivery systems have enough potential to do so. This article addresses the various barriers to the transportation of drugs through certain routes and also the common excipients which used to develop the lipid-based drug delivery systems. It provides a thorough overview of the lipid formulation classification scheme (LFCS) and also deals with several formulation & evaluation aspects of lipid-based drug delivery system. Further, it focuses on the formulations which are already available in the market and their regulatory concerns, respectively.

scholarly journals Optimization of Rifapentine-Loaded Lipid Nanoparticles Using a Quality-by-Design Strategy

Pharmaceutics ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 75 ◽  
Author(s):  
Joana Magalhães ◽  
Luise L. Chaves ◽  
Alexandre C. Vieira ◽  
Susana G. Santos ◽  
Marina Pinheiro ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Quality By Design ◽  
Lipid Nanoparticles ◽  
Delivery Systems ◽  
Human Macrophage ◽  
Scanning Calorimetry ◽  
Transmission Electron Microscopy Analysis ◽  
Electron Microscopy Analysis ◽  
Quality By Design Approach

This work aims to optimize and assess the potential use of lipid nanoparticles, namely nanostructured lipid carriers (NLCs), as drug delivery systems of rifapentine (RPT) for the treatment of tuberculosis (TB). A Box–Behnken design was used to increase drug encapsulation efficiency (EE) and loading capacity (LC) of RPT-loaded NLCs. The optimized nanoparticles were fully characterized, and their effect on cell viability was assessed. The quality-by-design approach allowed the optimization of RPT-loaded NLCs with improved EE and LC using the minimum of experiments. Analyses of variance were indicative of the validity of this model to optimize this nanodelivery system. The optimized NLCs had a mean diameter of 242 ± 9 nm, polydispersity index <0.2, and a highly negative zeta potential. EE values were higher than 80%, and differential scanning calorimetry analysis enabled the confirmation of the efficient encapsulation of RPT. Transmission electron microscopy analysis showed spherical nanoparticles, uniform in shape and diameter, with no visible aggregation. Stability studies indicated that NLCs were stable over time. No toxicity was observed in primary human macrophage viability for nanoparticles up to 1000 μg mL−1. Overall, the optimized NLCs are efficient carriers of RPT and should be considered for further testing as promising drug delivery systems to be used in TB treatment.

Essentials of Pharmaceutical Product Development for Magnetically Modulated Drug Delivery Systems

2012 ◽  
Vol 4 (4) ◽  
pp. 1519-1527
Author(s):  
Vinod K R ◽  
Sridhar D ◽  
Sandhya S ◽  
Banji D ◽  
Rohit Reddy T
Keyword(s):  
Drug Delivery ◽  
Drug Targeting ◽  
Drug Delivery Systems ◽  
Evaluation Studies ◽  
Delivery Systems ◽  
Histological Evaluation ◽  
Magnetic Drug Targeting ◽  
Formulation Development ◽  
In Vivo Evaluation ◽  
Magnetic Drug Delivery

There is a renewed focus on developing formulation strategies for the regional drug targeting. Magnetic drug targeting provides an innovative approach that may include two and three dimensional arrays of magnetic drug delivery systems. Applications of magnetic microsphere-based drug delivery include chemotherapy, arthritis, gene, and cell transplantation therapy. This article describes different formulation approaches, routes of administration, and mechanisms of magnetic-based drug targeting. Magnetic materials have to be synthesized before considering the formulation development. Although the preparation evaluation of magnetic drug delivery is comparable with conventional microspheres and nanoparticles, characterization of magnetic properties of the final formulation is very essential for success of this approach.  In vivo evaluation studies include tumor targeting in animals, histological evaluation using MRI and course of the magnetic drug delivery system by image mapping using suitable biological markers.

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