Design and characterization of submicron formulation for a poorly soluble drug: The effect of Vitamin E TPGS and other solubilizers on skin permeability enhancement

2012 ◽  
Vol 434 (1-2) ◽  
pp. 90-98 ◽  
Author(s):  
Indrajit Ghosh ◽  
Bozena Michniak-Kohn
Keyword(s):  
Vitamin E ◽  
Skin Permeability ◽  
Permeability Enhancement ◽  
Vitamin E Tpgs ◽  
Poorly Soluble ◽  
Poorly Soluble Drug

Studies on the Preparation, Characterization and Solubility of -Cyclodextrin-Roxythromycin Inclusion Complexes

2009 ◽  
Vol 2 (2) ◽  
pp. 523-530
Author(s):  
D. Nagasamy Venkatesh ◽  
S. Karthick ◽  
M. Umesh ◽  
G. Vivek ◽  
R.M. Valliappan ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Inclusion Complexes ◽  
Phase Solubility ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Ir Studies ◽  
Poorly Soluble ◽  
Poorly Soluble Drug

Roxythromycin/ β-cyclodextrin (Roxy/ β-CD) dispersions were prepared with a view to study the influence of β-CD on the solubility and dissolution rate of this poorly soluble drug. Phase-solubility profile indicated that the solubility of roxythromycin was significantly increased in the presence of β-cyclodextrin and was classified as AL-type, indicating the 1:1 stoichiometric inclusion complexes. Physical characterization of the prepared systems was carried out by differential scanning calorimetry (DSC), X-ray diffraction studies (XRD) and IR studies. Solid state characterization of the drug β-CD binary system using XRD, FTIR and DSC revealed distinct loss of drug crystallinity in the formulation, ostensibly accounting for enhancement of dissolution rate.

Nanocrystal formulations of a poorly soluble drug. 1. In vitro characterization of stability, stabilizer adsorption and uptake in liver cells

2017 ◽  
Vol 518 (1-2) ◽  
pp. 29-40 ◽  
Author(s):  
Kalle Sigfridsson ◽  
Urban Skantze ◽  
Pia Skantze ◽  
Svante Johansson ◽  
Iain Grant ◽  
...  
Keyword(s):  
Liver Cells ◽  
In Vitro Characterization ◽  
Poorly Soluble ◽  
Poorly Soluble Drug

scholarly journals Preparation and characterization of Alendronate depot microspheres based on novel poly(-ε-caprolactone)/Vitamin E TPGS copolymers

2019 ◽  
Vol 1 ◽  
pp. 100014 ◽  
Author(s):  
Christina Koulouktsi ◽  
Stavroula Nanaki ◽  
Panagiotis Barmpalexis ◽  
Margaritis Kostoglou ◽  
Dimitrios Bikiaris
Keyword(s):  
Vitamin E ◽  
Vitamin E Tpgs

scholarly journals Preparation and characterization of a nanostructured lipid carrier for a poorly soluble drug

2014 ◽  
Vol 455 ◽  
pp. 36-43 ◽  
Author(s):  
Yiyin Chen ◽  
Xiaomin Yang ◽  
Lin Zhao ◽  
László Almásy ◽  
Vasil M. Garamus ◽  
...  
Keyword(s):  
Nanostructured Lipid Carrier ◽  
Poorly Soluble ◽  
Poorly Soluble Drug

Characterization of solid dispersions of itraconazole and vitamin E TPGS prepared by microwave technology

2010 ◽  
Vol 2 (2) ◽  
pp. 237-246 ◽  
Author(s):  
Mariarosa Moneghini ◽  
Nicola De Zordi ◽  
Dario Solinas ◽  
Stefano Macchiavelli ◽  
Francesco Princivalle
Keyword(s):  
Vitamin E ◽  
Solid Dispersions ◽  
Microwave Technology ◽  
Vitamin E Tpgs

Development and characterization of a novel nanosuspension based drug delivery system of valsartan: A poorly soluble drug

2015 ◽  
Vol 9 (1) ◽  
pp. 29 ◽  
Author(s):  
Suryadevera Vidyadhara ◽  
Kunam Viswanadh ◽  
Prakash Shetiya ◽  
Anne Ramu ◽  
ReddyvalamLankapalli Sasidhar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Poorly Soluble ◽  
Poorly Soluble Drug
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