Investigation of drug–polymer interaction in solid dispersions by vapour sorption methods

2014 ◽  
Vol 469 (1) ◽  
pp. 159-167 ◽  
Author(s):  
Kateřina Punčochová ◽  
Jerry Y.Y. Heng ◽  
Josef Beránek ◽  
František Štěpánek
Keyword(s):  
Solid Dispersions ◽  
Vapour Sorption ◽  
Drug Polymer Interaction ◽  
Polymer Interaction

Polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft co-polymer based controlled release tablets of aceclofenac to simultaneously enhance the solubility and bioavailability

2021 ◽  
pp. 1-13
Author(s):  
Barkat Ali Khan ◽  
Muhammad Kamran Khan ◽  
Naeem Haider ◽  
Farid Menaa ◽  
Muhammad Khalid Khan
Keyword(s):  
Polyethylene Glycol ◽  
Controlled Release ◽  
Polyvinyl Acetate ◽  
Solid Dispersions ◽  
Compression Method ◽  
Zero Order Kinetics ◽  
Drug Polymer Interaction ◽  
Tablet Dosage ◽  
Controlled Release Tablets ◽  
Polymer Interaction

The aim of this study was to enhance the solubility of Aceclofenac with a new polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft co-polymer (Soloplus ®) and formulate it in controlled release (CR) tablet dosage form by direct compression method with HPMC K-15. Solid dispersions were prepared in different ratio of Aceclofenac and Soloplus ® as F1, F2 and F3 with different polymer ratios i.e. 30%, 50%, and 70% respectively. All the quality control tests were performed for the prepared controlled release tablets. Drug polymer interaction studies of Aceclofenac and Soloplus ® were carried using FTIR and XRD. Dissolution study was carried out against Alkaris ® as a standard reference. The formulation F3 showed optimum results and followed zero order kinetics. The Soloplus ® improved the solubility of the drug and the CR formulation enhanced the delivery in a sustained manner. Hence, the CR formulation enhanced the delivery of aceclofenac in a sustained manner, thereby an efficient drug delivery may lead to an effective anti-inflammatory activity.

scholarly journals Molecular Interactions for the Curcumin-Polymer Complex with Enhanced Anti-Inflammatory Effects

Pharmaceutics ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 442 ◽  
Author(s):  
Yan He ◽  
Hongfei Liu ◽  
Wangqing Bian ◽  
Yue Liu ◽  
Xinyang Liu ◽  
...  
Keyword(s):  
Molecular Interactions ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Dynamics Simulation ◽  
Amorphous Solid Dispersion ◽  
Polymer Complex ◽  
Formulation Development ◽  
Anti Inflammatory ◽  
Drug Polymer Interaction ◽  
Polymer Interaction

The molecular interactions between compound and polymeric carriers are expected to highly contribute to high drug load and good physical stability of solid dispersions. In this study, a series of amorphous solid dispersions (ASD) of Curcumin (Cur) were prepared with different polymers by the solvent evaporation method. With the carrier polyvinylpyrrolidone (PVP), the amorphous solid dispersion system exhibits a better solubility and stability than that with poloxamers and HP-β-CD due to the strong drug-polymer interaction. The drug/polymer interaction and their binding sites were investigated by combined experimental (XRD, DSC, FTIR, SEM, Raman, and 1H-NMR) and molecular dynamics simulation techniques. The Curcumin ASD demonstrated enhanced bioavailability by 11-fold and improved anti-inflammatory activities by the decrease in cytokine production (MMP-9, IL-1β, IL-6, VEGF, MIP-2, and TNF-α) compared to the raw Curcumin. The integration of experimental and modeling techniques is a powerful tool for the rational design of formulation development.

Impact of Drug-Polymer Interaction in Amorphous Solid Dispersion Aiming for the Supersaturation of Poorly Soluble Drug in Biorelevant Medium

2020 ◽  
Vol 21 (5) ◽  
Author(s):  
Cassiana Mendes ◽  
Rafael G. Andrzejewski ◽  
Juliana M. O. Pinto ◽  
Leice M. R. de Novais ◽  
Andersson Barison ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersion ◽  
Poorly Soluble ◽  
Poorly Soluble Drug ◽  
Drug Polymer Interaction ◽  
Biorelevant Medium ◽  
Polymer Interaction

scholarly journals Drug release from thin films encapsulated by a temperature-responsive hydrogel

Soft Matter ◽  
2019 ◽  
Vol 15 (8) ◽  
pp. 1853-1859 ◽  
Author(s):  
Oliver Werzer ◽  
Stephan Tumphart ◽  
Roman Keimel ◽  
Paul Christian ◽  
Anna Maria Coclite
Keyword(s):  
Thin Films ◽  
Controlled Release ◽  
Drug Release ◽  
Temperature Responsive ◽  
Temperature Controlled ◽  
Drug Polymer Interaction ◽  
Polymer Interaction

Temperature-controlled release and study on the effects of the drug–polymer interaction and pH.

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