Drug release from thin films encapsulated by a temperature-responsive hydrogel

We report synthesis, characterization, and drug release attributes of a series of novel pH-sensitive poly(acrylic-co-vinylsulfonic) acid hydrogels. These hydrogels were prepared by employing free radical polymerization using ethylene glycol dimethacrylate (EGDMA) and benzyl peroxide (BPO) as cross-linker and initiator, respectively. Effect of acrylic acid (AA), polyvinylsulfonic acid (PVSA), and EGDMA on prepared hydrogels was investigated. All formulations showed higher swelling at high pHs and vice versa. Formulations containing higher content of AA and EGDMA show reduced swelling, but one with higher content of PVSA showed increased swelling. Hydrogel network was characterized by determining structural parameters and loaded with isosorbide mononitrate. FTIR confirmed absence of drug polymer interaction while DSC and TGA demonstrated molecular dispersion of drug in a thermally stable polymeric network. All the hydrogel formulations exhibited a pH dependent release of isosorbide mononitrate which was found to be directly proportional to pH of the medium and PVSA content and inversely proportional to the AA contents. Drug release data were fitted to various kinetics models. Results indicated that release of isosorbide mononitrate from poly(AA-co-VSA) hydrogels was non-Fickian and that the mechanism was diffusion-controlled.

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Polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft co-polymer based controlled release tablets of aceclofenac to simultaneously enhance the solubility and bioavailability

Main Group Chemistry ◽

10.3233/mgc-210057 ◽

2021 ◽

pp. 1-13

Author(s):

Barkat Ali Khan ◽

Muhammad Kamran Khan ◽

Naeem Haider ◽

Farid Menaa ◽

Muhammad Khalid Khan

Keyword(s):

Polyethylene Glycol ◽

Controlled Release ◽

Polyvinyl Acetate ◽

Solid Dispersions ◽

Compression Method ◽

Zero Order Kinetics ◽

Drug Polymer Interaction ◽

Tablet Dosage ◽

Controlled Release Tablets ◽

Polymer Interaction

The aim of this study was to enhance the solubility of Aceclofenac with a new polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft co-polymer (Soloplus ®) and formulate it in controlled release (CR) tablet dosage form by direct compression method with HPMC K-15. Solid dispersions were prepared in different ratio of Aceclofenac and Soloplus ® as F1, F2 and F3 with different polymer ratios i.e. 30%, 50%, and 70% respectively. All the quality control tests were performed for the prepared controlled release tablets. Drug polymer interaction studies of Aceclofenac and Soloplus ® were carried using FTIR and XRD. Dissolution study was carried out against Alkaris ® as a standard reference. The formulation F3 showed optimum results and followed zero order kinetics. The Soloplus ® improved the solubility of the drug and the CR formulation enhanced the delivery in a sustained manner. Hence, the CR formulation enhanced the delivery of aceclofenac in a sustained manner, thereby an efficient drug delivery may lead to an effective anti-inflammatory activity.

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Design and In vitro Evaluation of floating tablets Containing Atazanavir Sulphate.

Research Journal of Pharmacy and Technology ◽

10.52711/0974-360x.2021.00487 ◽

2021 ◽

pp. 2763-2770

Author(s):

Gurram Lakshmana murthy ◽

Vasia Tamreen ◽

Chandrika C. ◽

Shazia Iryn ◽

Suchitra M ◽

...

Keyword(s):

Drug Release ◽

Sustained Release ◽

Ethyl Cellulose ◽

Research Work ◽

Matrix Tablets ◽

Gastric Residence Time ◽

Floating Drug Delivery ◽

Drug Polymer Interaction ◽

Polymer Interaction

The main of the research work to develop sustained release floating matrix tablets of ATZ, which were designed to extend the gastric residence time and prolong the drug release after oral administration. Different grades of polymers such as EC and HPMC K100M were used in order to get the desired floating and sustained release profile over prolonged period of time. All the formulations extended the drug release up to 24 hours and more and the formulations were optimized for the desired release profiles. The release and floating property was depends on the polymer type and polymer proportion. The formulation prepared with Ethyl cellulose and HPMC K100M has more floating time than the formulation prepared with the Ethyl cellulose alone. The FTIR study shows that there is no drug-polymer interaction. This study gives the preliminary idea about the development of the floating drug delivery systems of Atazanavir without the use of gas generating agent.

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Drug physical state and drug–polymer interaction on drug release from chitosan matrix films

Journal of Controlled Release ◽

10.1016/s0168-3659(01)00389-3 ◽

2001 ◽

Vol 75 (1-2) ◽

pp. 143-153 ◽

Cited By ~ 156

Author(s):

S Puttipipatkhachorn ◽

J Nunthanid ◽

K Yamamoto ◽

G.E Peck

Keyword(s):

Drug Release ◽

Physical State ◽

Chitosan Matrix ◽

Drug Polymer Interaction ◽

Polymer Interaction

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Drug Release Kinetics and Front Movement in Matrix Tablets Containing Diltiazem or Metoprolol/λ-Carrageenan Complexes

BioMed Research International ◽

10.1155/2014/671532 ◽

2014 ◽

Vol 2014 ◽

pp. 1-8 ◽

Cited By ~ 7

Author(s):

Ruggero Bettini ◽

Maria Cristina Bonferoni ◽

Paolo Colombo ◽

Laura Zanelotti ◽

Carla Caramella

Keyword(s):

Drug Release ◽

Release Kinetics ◽

Matrix Tablets ◽

Drug Dissolution ◽

Stable Complex ◽

Drug Release Kinetics ◽

The Matrix ◽

Poorly Soluble ◽

Drug Polymer Interaction ◽

Polymer Interaction

In this work we investigated the moving boundaries and the associated drug release kinetics in matrix tablets prepared with two complexes betweenλ-carrageenan and two soluble model drugs, namely, diltiazem HCl and metoprolol tartrate aiming at clarifying the role played by drug/polymer interaction on the water uptake, swelling, drug dissolution, and drug release performance of the matrix. The two studied complexes released the drug with different mechanism indicating two different drug/polymer interaction strengths. The comparison between the drug release behaviour of the complexes and the relevant physical mixtures indicates that diltiazem gave rise to a less soluble and more stable complex with carrageenan than metoprolol. The less stable metoprolol complex afforded an erodible matrix, whereas the stronger interaction between diltiazem and carrageenan resulted in a poorly soluble, slowly dissolving matrix. It was concluded that the different stability of the studied complexes affords two distinct drug delivery systems: in the case of MTP, the dissociation of the complex, as a consequence of the interaction with water, affords a classical soluble matrix type delivery system; in the case of DTZ, the dissolving/diffusing species is the complex itself because of the very strong interaction between the drug and the polymer.

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Evaluation of Aceclofenac Loaded Alginate Mucoadhesive Spheres Prepared by Ionic Gelation

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2012.5.4.4 ◽

2013 ◽

Vol 5 (4) ◽

pp. 1847-1857

Author(s):

M. Mohan Varma ◽

H.L.N Rao

Keyword(s):

Controlled Release ◽

Sodium Alginate ◽

Calcium Chloride ◽

Zero Order ◽

Fickian Diffusion ◽

Content Uniformity ◽

Drug Content ◽

Mucoadhesive Property ◽

Drug Polymer Interaction ◽

Polymer Interaction

Controlled release aceclofenac spheres were prepared in a cross-linked alginate matrix using ionotropic gelation technique. A suspension of aceclofenac in sodium alginate solution was added drop wise into 10% w/v calcium chloride solution and the resulting spheres were evaluated for their drug content, flow properties, mucoadhesive property and the dissolution rate. The aceclofenac loaded alginate spheres were prepared using various mucoadhesive polymers: sodium alginate, HPMC, sodium CMC, guar gum, methyl cellulose and carbopol. The calcium chloride was used as the crosslinking agent. Fourier transform infrared spectroscopy (FTIR) was used to evaluate the drug-polymer interaction. The alginate spheres showed good rheological properties, drug content uniformity and high entrapment efficiency. The aceclofenac release from the spheres was slow and extended up to 10 hours. The drug loaded spheres exhibited good mucoadhesive property in the in vitro wash off test. The drug release from the optimized formulation (drug-sodium alginate-HPMC K15M; 1:0.9: 0.1 ratio) followed zero order kinetics and exhibited non-Fickian diffusion. The rate of release of aceclofenac decreased with increasing concentration of sodium alginate due to slow penetration of dissolution fluid in the spheres. The results suggest that alginate spheres can potentially deliver aceclofenac at zero-order controlled release following oral administration. The FTIR studies indicated the absence of the drug-polymer interaction in the solid state.

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Preparation of Gefitinib Loaded Polycaprolactone Microcapsule For Controlled Release Drug Delivery System

International Journal of Pharmacology and Pharmaceutical Technology ◽

10.47893/ijppt.2017.1025 ◽

2017 ◽

pp. 57-61

Author(s):

Priyangi Roy ◽

Purusattam Gartia ◽

Aritra Nayek ◽

Asok Kumar Samanta

Keyword(s):

Controlled Release ◽

Average Particle Size ◽

Subcutaneous Administration ◽

Entrapment Efficiency ◽

In Vitro Dissolution ◽

Average Particle ◽

Drug Entrapment Efficiency ◽

Drug Polymer Interaction ◽

Polymer Interaction

The aim of the study was to prepare gefitinib-loaded polycaprolactone microcapsules by simple conventional solvent evaporation method with a view to achieve controlled release of the drug following subcutaneous administration once in a week for targeted therapeutic action especially locally. The microcapsules were prepared using different drug-polymer ratios (1:2, 1:4 and 1:6) and three different stabilizers/surfactants (0.25% w/v, 0.50% w/v and 0.75% w/v) concentrations in aqueous phase. Depending upon the formulation variables, the highest drug entrapment efficiency and the lowest average particle size diameter of the microcapsules were found to be respectively 90.19±2.61 % and 201±3.05 µ. Comparison of Fourier Transform Infra Red spectra of gefitinib, polycaprolactone, their physical mixture and the drug- loaded microcapsules showed the absence of drug -polymer interaction .The in-vitro dissolution study showed that the release of drug from the microcapsules was almost complete on day seventh and the drug release followed Higuchi model.

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