Cochlear implantation under the first year of age—The outcomes. A critical systematic review and meta-analysis

2010 ◽  
Vol 74 (2) ◽  
pp. 119-126 ◽  
Author(s):  
Petros V. Vlastarakos ◽  
Konstantinos Proikas ◽  
George Papacharalampous ◽  
Irene Exadaktylou ◽  
George Mochloulis ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cochlear Implantation ◽  
Meta Analysis ◽  
First Year

Safety of Cochlear Implantation in Children 12 Months or Younger: Systematic Review and Meta-analysis

2022 ◽  
pp. 019459982110677
Author(s):  
Firas Sbeih ◽  
Malek H. Bouzaher ◽  
Swathi Appachi ◽  
Seth Schwartz ◽  
Michael S. Cohen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cochlear Implants ◽  
Cochlear Implantation ◽  
Meta Analysis ◽  
Cochrane Central Register ◽  
Ovid Medline ◽  
Central Register ◽  
Data Source ◽  
Anesthetic Complications ◽  
Full Text Screening

Objective To systematically review the literature to determine safety of cochlear implantation in pediatric patients 12 months and younger. Data Source Ovid MEDLINE, EMBASE, CINAHL, and Cochrane Central Register of Controlled Trials (CENTRAL) databases were searched from inception to March 20, 2021. Review Methods Studies that involved patients 12 months and younger with report of intraoperative or postoperative complication outcomes were included. Studies selected were reviewed for complications, explants, readmissions, and prolonged hospitalizations. Two independent reviewers screened all studies that were selected for the systematic review and meta-analysis. All studies included were assessed for quality and risk of bias. Results The literature search yielded 269 studies, of which 53 studies underwent full-text screening, and 18 studies were selected for the systematic review and meta-analysis. A total of 449 patients and 625 cochlear implants were assessed. Across all included studies, major complications were noted in 3.1% of patients (95% CI, 0.8-7.1) and 2.3% of cochlear implantations (95% CI, 0.6-5.2), whereas minor complications were noted in 2.4% of patients (95% CI, 0.4-6.0) and 1.8% of cochlear implantations (95% CI, 0.4-4.3). There were no anesthetic complications reported across all included studies. Conclusion The results of this systematic review and meta-analysis suggest that cochlear implantation in patients 12 months and younger is safe with similar rates of complications to older cohorts.

scholarly journals Effect of Bisphosphonates on Bone Health in Adult Renal Transplant Patients: Beyond the First Year Posttransplant—A Systematic Review and Meta-Analysis

2019 ◽  
Vol 6 ◽  
pp. 205435811985801 ◽  
Author(s):  
Alyssa Lip ◽  
Ashley Warias ◽  
M. Khaled Shamseddin ◽  
Benjamin Thomson ◽  
D. Thiwanka Wijeratne
Keyword(s):  
Systematic Review ◽  
Lumbar Spine ◽  
Renal Transplant ◽  
Bone Health ◽  
Observational Studies ◽  
Meta Analysis ◽  
First Year ◽  
Bisphosphonate Treatment ◽  
Mineral Density

Background: Bone mineral density (BMD) decreases postrenal transplantation. Evidence demonstrating the effects of bisphosphonates on BMD and fracture risk beyond 1-year posttransplant is sparse in existing literature, but remains essential to enhance clinical outcomes in this population. Objective: Our study aimed to systematically review and meta-analyze the current literature on the use of any bisphosphonate in the adult renal transplant population beyond the first year of renal transplant to determine its effect on BMD and fracture incidence. Design: We conducted a systematic review and meta-analysis of primary research literature that included full-text, English-language, original randomized clinical trials (RCTs) and observational studies. Setting: Patient data were primarily captured in an outpatient setting across various studies. Patients: Our population of interest was patients older than 18 years who received deceased/living donor kidney transplantation and any bisphosphonate with a follow-up greater than 12 months posttransplantation. Measurements: The primary outcome was change in BMD from baseline. Secondary outcomes were the incidence of fractures and effects of other confounders on bone health. Methods: We included RCTs and observational studies that satisfied our inclusion criteria. Each study was analyzed for risk of bias and data were extrapolated to analyze for overall statistical significance accounting for heterogeneity of studies. Results: Sixteen studies (N = 1762) were analyzed. The follow-up ranged from 12 to 98 months. There was a nonsignificant improvement in BMD with bisphosphonate treatment persisting into the second and third years posttransplant at the lumbar spine. The calculated standardized mean BMD difference was −0.29 (−0.75 to 0.17), P = .22. Only 5 studies reported a total of 43 new fractures. Prednisone ( P < .01), low body weight ( P < .001), low body mass index ( P < .01), and male gender ( P < .05) correlated with reduced lumbar and femoral BMD. Limitations: Limitations of this review include the use of BMD as a surrogate outcome, the bias of the included studies, and the incomplete reporting data in numerous analyzed studies. Conclusions: We demonstrate no statistically significant benefit of bisphosphonate treatment on BMD beyond the first year postrenal transplantation. Despite heterogeneity of treatment, a differential nonsignificant improvement in lumbar spine BMD was consistent and may be clinically relevant. Trial Registration: PROSPERO CRD42019125593

Cochlear Implantation for Treatment of Tinnitus in Single-sided Deafness: A Systematic Review and Meta-analysis

2020 ◽  
Vol 41 (8) ◽  
pp. e1004-e1012 ◽  
Author(s):  
Dylan A. Levy ◽  
Joshua A. Lee ◽  
Shaun A. Nguyen ◽  
Theodore R. McRackan ◽  
Ted A. Meyer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cochlear Implantation ◽  
Meta Analysis ◽  
Single Sided Deafness

Relative Energy Expenditure Decreases during the First Year after Bariatric Surgery: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 29 (8) ◽  
pp. 2648-2659 ◽  
Author(s):  
Fernando Lamarca ◽  
Mariana Silva Melendez-Araújo ◽  
Isabela Porto de Toledo ◽  
Eliane Said Dutra ◽  
Kênia Mara Baiocchi de Carvalho
Keyword(s):  
Systematic Review ◽  
Bariatric Surgery ◽  
Energy Expenditure ◽  
Meta Analysis ◽  
Relative Energy ◽  
First Year

Cochlear Implantation in Meniere's Disease: A Systematic Review and Meta‐Analysis

2021 ◽  
Author(s):  
Dillan F. Villavisanis ◽  
Maria A. Mavrommatis ◽  
Elisa R. Berson ◽  
Christopher P. Bellaire ◽  
John W. Rutland ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cochlear Implantation ◽  
Meta Analysis ◽  
Meniere’S Disease ◽  
Menière’S Disease ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Ménière's Disease

scholarly journals Systematic review and meta-analyses of risk factors for childhood overweight identifiable during infancy

2012 ◽  
Vol 97 (12) ◽  
pp. 1019-1026 ◽  
Author(s):  
Stephen Franklin Weng ◽  
Sarah A Redsell ◽  
Judy A Swift ◽  
Min Yang ◽  
Cristine P Glazebrook
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Weight Gain ◽  
Meta Analysis ◽  
Childhood Overweight ◽  
Overweight And Obesity ◽  
Future Research ◽  
First Year ◽  
First Year Of Life ◽  
Infant Birth

ObjectiveTo determine risk factors for childhood overweight that can be identified during the first year of life to facilitate early identification and targeted intervention.DesignSystematic review and meta-analysis.Search strategyElectronic database search of MEDLINE, EMBASE, PubMed and CAB Abstracts.Eligibility criteriaProspective observational studies following up children from birth for at least 2 years.ResultsThirty prospective studies were identified. Significant and strong independent associations with childhood overweight were identified for maternal pre-pregnancy overweight, high infant birth weight and rapid weight gain during the first year of life. Meta-analysis comparing breastfed with non-breastfed infants found a 15% decrease (95% CI 0.74 to 0.99; I2=73.3%; n=10) in the odds of childhood overweight. For children of mothers smoking during pregnancy there was a 47% increase (95% CI 1.26 to 1.73; I2=47.5%; n=7) in the odds of childhood overweight. There was some evidence associating early introduction of solid foods and childhood overweight. There was conflicting evidence for duration of breastfeeding, socioeconomic status at birth, parity and maternal marital status at birth. No association with childhood overweight was found for maternal age or education at birth, maternal depression or infant ethnicity. There was inconclusive evidence for delivery type, gestational weight gain, maternal postpartum weight loss and ‘fussy’ infant temperament due to the limited number of studies.ConclusionsSeveral risk factors for both overweight and obesity in childhood are identifiable during infancy. Future research needs to focus on whether it is clinically feasible for healthcare professionals to identify infants at greatest risk.

Time-patterns of annualized relapse rates in randomized placebo-controlled clinical trials in relapsing multiple sclerosis: A systematic review and meta-analysis

2012 ◽  
Vol 18 (9) ◽  
pp. 1290-1296 ◽  
Author(s):  
Richard Nicholas ◽  
Sebastian Straube ◽  
Heinz Schmidli ◽  
Sebastian Pfeiffer ◽  
Tim Friede
Keyword(s):  
Multiple Sclerosis ◽  
Systematic Review ◽  
Meta Analysis ◽  
First Year ◽  
Controlled Trials ◽  
Regression To The Mean ◽  
Placebo Controls ◽  
Time Patterns ◽  
Meta Analyses ◽  
Relapsing Multiple Sclerosis

Background: Although it is known that the annualized relapse rate (ARR) in patients with multiple sclerosis (MS) changes as disease progresses, in the design and analysis of trials in relapsing multiple sclerosis (RMS) constant ARRs are assumed. Objectives: This paper aims to assess time-patterns of trial ARR by conducting a systematic review of randomized, placebo-controlled trials in RMS. Methods: A systematic literature search was conducted by searching PubMed for randomized, placebo-controlled trials in RMS. In meta-analyses the following comparisons of trial ARR were carried out for the placebo controls and active treatment arms: months 1–6 vs. months 7–12, and months 1–12 vs. months 13–24. Results: A total of 52 trials was identified. Out of these, information on the time-dependence of trial ARR could be extracted from 13 trials. The ARR was by 25% ( p = 0.0005) and 40% ( p < 0.0001) higher in months 1–12 compared with months 13–24 for placebo and active treatments, respectively. Consequently, the treatment effects were by 13% ( p = 0.23) larger in the second year compared with the first year. Within the first year of follow-up the ARR was by 4% ( p = 0.75) and 23% ( p = 0.06) higher in months 1–6 compared with months 7–12 for placebo controls and active arms, respectively. Conclusions: Trial ARR decreases during a trial in RMS, which is in line with epidemiological findings and has implications for design and analysis of future trials. The observed decrease in trial ARR might be at least partially explained by regression to the mean. Individual patient data analyses are warranted.

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