Electrically evoked auditory brainstem responses to electrical stimulation at round window membrane in congenitally deaf children at different ages

2021 ◽  
pp. 110821
Author(s):  
Li Chen ◽  
Jun-Ge Zhang ◽  
Jing-Wu Sun ◽  
Xiao-Tao Guo ◽  
Jia-Qiang Sun
Keyword(s):  
Electrical Stimulation ◽  
Round Window ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses ◽  
Deaf Children ◽  
Round Window Membrane ◽  
Different Ages

scholarly journals Consecutive Treatment with Brain-Derived Neurotrophic Factor and Electrical Stimulation Has a Protective Effect on Primary Auditory Neurons

2020 ◽  
Vol 10 (8) ◽  
pp. 559 ◽  
Author(s):  
Verena Scheper ◽  
Ira Seidel-Effenberg ◽  
Thomas Lenarz ◽  
Timo Stöver ◽  
Gerrit Paasche
Keyword(s):  
Electrical Stimulation ◽  
Neurotrophic Factor ◽  
Combined Treatment ◽  
Spiral Ganglion ◽  
Brain Derived Neurotrophic Factor ◽  
Auditory Brainstem ◽  
Contralateral Side ◽  
Auditory Brainstem Responses ◽  
Drug Delivery Device ◽  
Ganglion Neurons

Degeneration of neurons, such as the inner ear spiral ganglion neurons (SGN), may be decelerated or even stopped by neurotrophic factor treatment, such as brain-derived neurotrophic factor (BDNF), as well as electrical stimulation (ES). In a clinical setting, drug treatment of the SGN could start directly during implantation of a cochlear implant, whereas electrical stimulation begins days to weeks later. The present study was conducted to determine the effects of consecutive BDNF and ES treatments on SGN density and electrical responsiveness. An electrode drug delivery device was implanted in guinea pigs 3 weeks after deafening and five experimental groups were established: two groups received intracochlear infusion of artificial perilymph (AP) or BDNF; two groups were treated with AP respectively BDNF in addition to ES (AP + ES, BDNF + ES); and one group received BDNF from the day of implantation until day 34 followed by ES (BDNF ⇨ ES). Electrically evoked auditory brainstem responses were recorded. After one month of treatment, the tissue was harvested and the SGN density was assessed. The results show that consecutive treatment with BDNF and ES was as successful as the simultaneous combined treatment in terms of enhanced SGN density compared to the untreated contralateral side but not in regard to the numbers of protected cells.

scholarly journals PromBERA: A preoperative eABR: An update

2018 ◽  
Vol 4 (1) ◽  
pp. 563-565 ◽  
Author(s):  
Daniel Polterauer ◽  
Maike Neuling ◽  
Joachim Müller ◽  
John-Martin Hempel ◽  
Giacomo Mandruzzato ◽  
...  
Keyword(s):  
Cochlear Implantation ◽  
Auditory Nerve ◽  
Round Window ◽  
Electrode Array ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses ◽  
Speech Comprehension ◽  
Testing Procedures ◽  
Brainstem Response ◽  
Round Window Niche

AbstractPrior to cochlear implantation, audiological tests are performed to determine candidacy in subjects with a hearing loss. This is usually done by measuring the acoustic auditory brainstem response (ABR). Unfortunately, for some subjects, a reproducible ABR recording cannot be obtained, even at high acoustic levels. Having a healthy stimulating auditory nerve is required for cochlear implantation in order to benefit from the electrical pulses that are generated by the implant and to improve speech comprehension. In some subjects, this prerequisite cannot be measured using routine audiological tests. In this study, the feasibility of recording electrically evoked auditory brainstem responses (eABR) using a stimulating transtympanic electrode, placed on the round window niche, together with MED-EL clinical system is investigated. The results show that it is possible to record reproducible eABR measurements using PromBERA. The response was also confirmed with intraoperative eABR measurements that were stimulated using the implanted CI electrode array. Similarities between the intraoperative measurements and the preoperative recorded waveforms were observed. In summary, the integrity and excitability of the auditory nerve can be objectively measured using the PromBERA in subjects where standard clinical testing procedures are unable to provide the information required.

Electrically Induced Auditory Brainstem Response as a Clinical Tool in Estimating Nerve Survival

1984 ◽  
Vol 93 (4_suppl) ◽  
pp. 97-100 ◽  
Author(s):  
F. Blair Simmons ◽  
Tom Meyers ◽  
Hugh S. Lusted ◽  
Clough Shelton
Keyword(s):  
Auditory Brainstem Response ◽  
Ganglion Cells ◽  
Round Window ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses ◽  
Scala Tympani ◽  
Clinical Tool ◽  
Large Populations ◽  
Brainstem Response ◽  
Better Than

Nerve survival estimates in totally deaf ears of cats and humans can be easily obtained by auditory brainstem responses to electrical stimulation at the round window. In humans, electrically induced auditory brainstem responses require considerably more current than concurrently observed perceptual thresholds and “maximum loudnesses,” and there is much variability from patient to patient. In cats, in which we also compared efficacy of stimulation sites, preliminary data analysis suggests that the scala tympani is clearly much more efficient than the round window, and the round window better than the promontory in ears with large populations of ganglion cells. In ears with no or nearly no ganglion cells, scala tympani and round window stimulations are about equal.

Electrical Stimulation of the Inner Ear

1973 ◽  
Vol 82 (4) ◽  
pp. 473-485 ◽  
Author(s):  
Richard Walloch ◽  
David DeWeese ◽  
Robert Brummett ◽  
Jack Vernon
Keyword(s):  
Electrical Stimulation ◽  
Inner Ear ◽  
Round Window ◽  
Spiral Ganglion ◽  
Electrode Placement ◽  
Round Window Membrane ◽  
Drug Induced ◽  
Cortical Responses ◽  
Electrical Stimuli ◽  
Stimulation Of

In the guinea pig the effects of electrical stimulation of the inner ear were measured by recording the evoked potentials at the auditory cortex. The cortical evoked responses to electrical stimuli greatly resembled those resulting from auditory stimuli in the same ears. The similarity was in wave shape, latency, duration, sharpness of thresholds, etc. It was also possible to produce evoked cortical responses when the electrical stimuli were delivered to ears suffering from severe acoustic trauma. These ears were so traumatized by acoustic over-stimulation that they were totally unresponsive to sound. In addition, it was possible to produce electrically evoked cortical responses in ears suffering from drug induced damage. The damage was of sufficient long standing as to produce extensive degeneration in the spiral ganglion. The damage was verified histologically and was severe enough to produce a 90% loss of the spiral ganglion cells. Similar electrical stimulation has been carried out in one human subject with normal hearing. Using sinusoidal electrical currents of approximately 10–100 microamperes, hearing sensations were produced only for stimulus frequencies between 4,000 Hz and 10,000 Hz. The intent had been to place a chronic electrode on the round window membrane of a normal human ear. When the same electrode was used to record the alternating current (a.c.) cochlear potential the resulting data were so insensitive as to suggest that the electrode placement had been less than ideal. Exploration revealed the electrode to have been on the floor of the fossula of the cochlea fenestra. A repeat procedure, with improved visualization, located a new chronic electrode on the round window membrane. Recordings and stimulations are currently in progress with that electrode.

Round Window Application of D-Methionine Provides Complete Cisplatin Otoprotection

2002 ◽  
Vol 126 (6) ◽  
pp. 683-689 ◽  
Author(s):  
Kurtis D. Korver ◽  
Leonard P. Rybak ◽  
Craig Whitworth ◽  
Kathleen M. Campbell
Keyword(s):  
Hearing Loss ◽  
Hair Cell ◽  
Outer Hair Cell ◽  
Round Window ◽  
Organ Of Corti ◽  
Cell Loss ◽  
Auditory Brainstem Responses ◽  
Round Window Membrane ◽  
Hair Cell Loss ◽  
Minute Amount

OBJECTIVE: Cisplatin is a widely used, very effective chemotherapeutic agent that can cause severe ototoxicity. In this study, D-methionine was tested as an otoprotectant via round window membrane (RWM) application in the chinchilla. METHODS: A minute amount of cisplatin alone, or D-methionine followed by cisplatin, was applied topically directly to the intact RWM of anesthetized adult chinchillas. Auditory brainstem responses were measured before and 1 week after topical round window application. Animals were killed, and the cochleas were examined. RESULTS: The ears pretreated with D-methionine were completely protected from hearing loss and hair cell loss in the organ of Corti compared with controls. The ears receiving cisplatin without D-methionine protection sustained nearly complete hearing loss with threshold shifts of >60 dB, with extensive outer hair cell loss throughout the organ of Corti but particularly in the basal turn. CONCLUSION: These results demonstrate that topical D-methionine provides excellent otoprotection against cisplatin-induced ototoxicity both electrophysiologically and structurally.

scholarly journals Hearing Loss after Round Window Surgery in Mice Is due to Middle Ear Effusion

2016 ◽  
Vol 21 (6) ◽  
pp. 356-364 ◽  
Author(s):  
Bovey Z. Zhu ◽  
Jasmine Saleh ◽  
Kevin T. Isgrig ◽  
Lisa L. Cunningham ◽  
Wade W. Chien
Keyword(s):  
Hearing Loss ◽  
Middle Ear ◽  
Hair Cells ◽  
Round Window ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses ◽  
Middle Ear Effusion ◽  
Injection Methods ◽  
Highly Correlated ◽  
Ear Effusion

Background: Delivery of therapeutic agents directly through the round window (RW) offers promise for treating sensorineural hearing loss. However, hearing loss can result from the surgical approach itself, and the reasons for this are poorly understood. We examined the hearing loss following the 3 major steps involved with the RW approach to access the mouse cochlea: bullostomy, RW puncture, and RW injection. Methods: Twenty-one adult CBA/J mice underwent bullostomy alone, 10 underwent RW puncture, and 8 underwent RW injection with PBS with 5% glycerol. Auditory brainstem responses (ABR) and otoscopy were performed preoperatively and up to 6 weeks postoperatively. Hair cells were stained, and survival was assessed using immunofluorescence. Results: One week postoperatively, mice in all groups showed significant threshold shifts. Otoscopy revealed approximately half of all mice had middle ear effusion (MEE), with a higher incidence of effusion in the RW puncture and RW injection groups. Those with MEE had significant ABR threshold shifts, whereas those without MEE had minimal hearing loss. MEE persisted through 6 weeks in a majority of cases, but in those mice with MEE resolution, there was at least partial improvement in hearing. Immunohistochemistry showed minimal loss of hair cells in all animals. Conclusion: MEE is highly correlated with hearing loss in mice undergoing RW surgery. Otoscopy is an important adjunct to consider after ear surgery in mice, as MEE may contribute to postsurgical hearing loss.

S228 – Direct Round Window Drug Application and Ototoxicity in Rats

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P151-P151
Author(s):  
Teresa Rivera ◽  
Fernando García Alcantara ◽  
Jon Alexander Sistiaga Suarez ◽  
Murillo-Cuesta Silvia ◽  
Vacas Elena ◽  
...  
Keyword(s):  
Round Window ◽  
Drug Application ◽  
Tone Burst ◽  
Auditory Brainstem ◽  
Round Window Membrane ◽  
Control Group ◽  
Cochlear Function ◽  
Before And After ◽  
Male Wistar Rats ◽  
Brainstem Response

Objectives 1) Manage to introduce ototoxic drugs, such as kanamycin and furosemide, directly on the round window in rats. 2) Use a purified gelatine sponge as a proper delivery vehicle. The purpose of the study is to assess the validity of this method to provoke local ototoxicity. Methods We carried out an experimental design with 3 groups of 6 male Wistar rats. The bulla and round window membrane were exposed using a ventral approach. In the first control group we only made a hole in the tympanic bulla. Second control group was treated with saline solution. The problem group was treated with 20 mg/kg of kanamycin and 5 mg/Kg of furosemide-soaked gelatine sponge directly upon the round window membrane. Cochlear function was assessed through tone burst auditory brainstem response (ABR) threshold (dB) and peak latency (ms) measurements. Anova with bonferroni correction was used (p level=0.05). Results All animals treated with kanamycin and furosemide exhibited significant increase in ABR threshold (x = 51.25 dB; SD = 6.29; p = 0,001) in contrast to the other groups, whose ABR thresholds did not show significant differences before and after treatment(x=31,50 dB; SD=5.53); and not significant increase in peak latencies I (x = 0.22 ms; SD = 0.12), II (x = 0.22 ms; SD = 0.20) and IV (x = 0.21 ms; SD = 0.18). Conclusions The ventral approach and placement of kanamycin and furosemide-soaked gelatine sponge directly upon the round window membrane represents a reliable method for ototoxicity in rats.

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