Cranial Radiation Therapy Induces Acute Cognitive Impairments in Patients with Brain Tumors Only

2005 ◽  
Vol 63 ◽  
pp. S155-S156
Author(s):  
G. Welzel ◽  
K. Fleckenstein ◽  
D. Thoennessen ◽  
B. Hermann ◽  
U. Kraus-Tiefenbacher ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Brain Tumors ◽  
Cognitive Impairments ◽  
Cranial Radiation

Magnetic resonance imaging evaluation of radiation: Cranial radiation therapy-induced diffuse white matter injury

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e13033-e13033
Author(s):  
T. Z. Mohran ◽  
M. M. Omar ◽  
M. A. Hameed ◽  
M. S. Elnaggar
Keyword(s):  
Radiation Therapy ◽  
White Matter ◽  
Brain Tumors ◽  
Spin Echo ◽  
White Matter Injury ◽  
High Signal ◽  
Imaging Evaluation ◽  
Post Contrast ◽  
Diffuse White Matter ◽  
Cranial Radiation

e13033 Background: To study the value of MRI in detection and grading of diffuse white matter injury induced by cranial radiation therapy for brain tumors and to evaluate the influence of various risk factors for its development. Methods: This study included 60 patients who had primary brain tumors and received external beam conventionally fractionated radiotherapy. Twenty-three out of 60 patients received chemotherapy after radiotherapy. Post radiotherapy follow-up MRI examination was performed for all patients at 6 weeks, 3, 6, 9, 12 months, and at more than 1 year from completion of radiotherapy. MR imaging was performed with T2-weighted turbo spin echo, fast fluid-attenuated inversion- recovery (FLAIR), T1-weighted spin-echo, and T1-weighted post-contrast spin-echo sequences. Results: Twenty-one of 60 patients (35%) developed diffuse white matter injury at a mean of 15.3 + 7.6 months from the completion of radiotherapy (range, 5–36 months). Radiation-related diffuse white matter changes were characterized as diffuse high signal intensity in the periventricular deep white matter on T2WI and FLAIR sequences. The MRI grading system of these periventricular hyperintensity (PVH) were as follow: 39 patients (65%) had no WMI (grade 0), four had grade 1 changes, three patients had grade 2 changes, nine patients had grade 3, and five patients had grade 4. They were symmetrical in 13 of 21 patients (61.9%), and asymmetrical in eight out of 21 patients (38.1%). The prevalence of diffuse matter injury found to be significantly related to the volume of irradiation (p = 0.02), fraction size (p = 0.008), and concomitant use of chemotherapy (p > 0.02)Conclusions: Diffuse white matter injury is a known consequence of radiation therapy, and the capability of detecting and grading such damage is optimally provided by MRI. No significant financial relationships to disclose.

A phase I study of cranial radiation therapy with concomitant continuous infusion paclitaxel in children with brain tumors

2001 ◽  
Vol 37 (4) ◽  
pp. 390-392 ◽  
Author(s):  
Li Liu ◽  
Neha Vapiwala ◽  
Louis K. Munoz ◽  
Naomi J. Winick ◽  
Steven Weitman ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Brain Tumors ◽  
Phase I ◽  
Continuous Infusion ◽  
Phase I Study ◽  
Cranial Radiation

scholarly journals Secondary brain tumors after cranial radiation therapy: A single-institution study

2020 ◽  
Vol 25 (2) ◽  
pp. 245-249
Author(s):  
Masazumi Fujii ◽  
Masahiro Ichikawa ◽  
Kensho Iwatate ◽  
Mudathir Bakhit ◽  
Masayuki Yamada ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Brain Tumors ◽  
Single Institution ◽  
Cranial Radiation

Effects of cranial radiation on hypothalamic-pituitary function in children with leukemia and brain tumors

1985 ◽  
Vol 110 (1_Suppla) ◽  
pp. S149-S150
Author(s):  
N. STAHNKE ◽  
P. HAUPT ◽  
R. P. WILLIG ◽  
G. SINNECKER ◽  
K. WINKLER
Keyword(s):  
Brain Tumors ◽  
Pituitary Function ◽  
Cranial Radiation

Evaluation and treatment of children with radiation-induced cerebral vasculopathy

2019 ◽  
Vol 24 (6) ◽  
pp. 680-688
Author(s):  
David S. Hersh ◽  
Kenneth Moore ◽  
Vincent Nguyen ◽  
Lucas Elijovich ◽  
Asim F. Choudhri ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Proton Beam ◽  
Tumor Imaging ◽  
Clinic Visit ◽  
Surgical Patient ◽  
Beam Radiation ◽  
Proton Beam Radiotherapy ◽  
Cranial Radiation ◽  
Delayed Complication ◽  
Radiation Induced

OBJECTIVEStenoocclusive cerebral vasculopathy is an infrequent delayed complication of ionizing radiation. It has been well described with photon-based radiation therapy but less so following proton-beam radiotherapy. The authors report their recent institutional experience in evaluating and treating children with radiation-induced cerebral vasculopathy.METHODSEligible patients were age 21 years or younger who had a history of cranial radiation and subsequently developed vascular narrowing detected by MR arteriography that was significant enough to warrant cerebral angiography, with or without ischemic symptoms. The study period was January 2011 to March 2019.RESULTSThirty-one patients met the study inclusion criteria. Their median age was 12 years, and 18 (58%) were male. Proton-beam radiation therapy was used in 20 patients (64.5%) and photon-based radiation therapy was used in 11 patients (35.5%). Patients were most commonly referred for workup as a result of incidental findings on surveillance tumor imaging (n = 23; 74.2%). Proton-beam patients had a shorter median time from radiotherapy to catheter angiography (24.1 months [IQR 16.8–35.4 months]) than patients who underwent photon-based radiation therapy (48.2 months [IQR 26.6–61.1 months]; p = 0.04). Eighteen hemispheres were revascularized in 15 patients. One surgical patient suffered a contralateral hemispheric infarct 2 weeks after revascularization; no child treated medically (aspirin) has had a stroke to date. The median follow-up duration was 29.2 months (IQR 21.8–54.0 months) from the date of the first catheter angiogram to last clinic visit.CONCLUSIONSAll children who receive cranial radiation therapy from any source, particularly if the parasellar region was involved and the child was young at the time of treatment, require close surveillance for the development of vasculopathy. A structured and detailed evaluation is necessary to determine optimal treatment.

LOCAL HYPERTHERMIA IN TREATMENT FOR MALIGNANT BRAIN TUMORS

2018 ◽  
Vol 64 (1) ◽  
pp. 54-61
Author(s):  
A. Ryabova ◽  
O. Gribova ◽  
V. Novikov ◽  
E. Choinzonov ◽  
Zh. Starceva ◽  
...  
Keyword(s):  
Experimental Data ◽  
Radiation Therapy ◽  
Brain Tumors ◽  
Tumor Cells ◽  
Combined Treatment ◽  
Complex Treatment ◽  
Local Hyperthermia ◽  
Malignant Brain Tumors ◽  
Sensitizing Effect ◽  
Methods Of Treatment

Unsatisfactory results of complex treatment for malignant brain tumors stimulate search of new effective methods of treatment. Radiation therapy is an integral part of the combined treatment but often does not influence lethally on resistant tumor cells. Thereby in recent decades there has been an active search for different modifiers, which can increase the sensitivity of tumors to chemotherapy and radiotherapy. One of the universal sensitizers is the local hyperthermia. Experimental data showed that the effect of high temperatures had both a direct damaging effect on tumor cells and a sensitizing effect. The literature review given in the article provides an overview of the existing methods of the local hyperthermia for brain tumors treatment.

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