AbstractPurpose: To evaluate the breathing amplitude, tumor motion, patient positioning, and treatment volumes among consecutive four-dimensional computed tomography (4D-CT) scans, during the simulation for lung stereotactic body radiation therapy (SBRT).Material and methods: The variation and shape of the breathing amplitude, patient positioning, and treatment volumes were evaluated for 55 lung cancer patients after consecutive 4D-CT acquisitions, scanned at one-week intervals. The impact of variation in the breathing amplitude on lung tumor motion was determined for 20 patients. The gross tumor volume (GTV) was contoured from a free-breathing CT scan and at ten phases of the respiratory cycle, for both 4D-CTs (440 phases in total).Results: Breathing amplitude decreased by 3.6 (3.4-4.9) mm, tumor motion by 3.2 (0.4-5.0) mm while breathing period increased by 4 (2-6) s, inter-scan for 20 patients. Intra-scan variation was 4 times greater for the breathing amplitude, 5 times for the breathing period, and 8 times for the breathing cycle, comparing irregular versus regular breathing patterns for 55 patients. Using coaching, the breathing amplitude increases 3 to 8 mm, and the breathing period 2 to 6 s. Differences in the contoured treatment volumes were less than 10% between consecutive scans. Patient positioning remained stable, with a small inter-scan difference of 1.1 (0.6-1.4) mm.Conclusion: Decreasing the inter-scan breathing amplitude decreases the tumor motion reciprocally. When the breathing amplitude decreases, the breathing period increases at inter- and intra-scan, especially during irregular breathing. Coaching improves respiration, keeping the initial shape of the breathing amplitude. Contoured treatment volumes and patient positioning were reproducible through successive scans.
Inter- and Intraobserver Variability in Daily Tumor Setup Using Contrast-Enhanced CT Scans for Patient Positioning During Stereotactic Body Radiation Therapy for Liver Metastases
