The Pattern of Lymph Node Metastasis With Adenocarcinoma of Esophagogastric Junction: A Rationale for Radiation Therapy Target Design

Abstract Introduction The tight junction molecule Claudin 18.2 is selectively expressed in healthy and malignant gastric epithelial tissue and is a promising therapy target for high Claudin 18.2 expressing adenocarcinomas of the esophagogastric junction and stomach (AEG/S). Methods This study analyzed the prevalence, characteristics and prognostic impact of Claudin 18.2 expression in primary tumor, lymph node and distant metastasis in a large Caucasian AGE/S cohort with 414 patients. Results Claudin 18.2 was highly expressed in 17.1% of primary tumors, 26.7% of lymph node metastasis and 16.7% of distant metastasis. High Claudin 18.2 expression in lymph node metastasis and primary tumors correlated significantly (p < 0.001). High expression of Claudin 18.2 was neither associated with histomorphogical subtype, or tumor state, nor with overall survival. Conclusion In Caucasian AEG/S patients, 17.1% appeared to be eligible for an anti-Claudin 18.2 therapy. Claudin 18.2 expression itself has no impact on prognosis and is not related to any tumor subtype.

Download Full-text

The probability of Lymph node metastasis with a tumor size larger than and smaller than 4 cm is different in stages T1-T3 of Siewert type II adenocarcinoma of esophagogastric junction: A Population-Based Study

Journal of Cancer ◽

10.7150/jca.63392 ◽

2021 ◽

Vol 12 (22) ◽

pp. 6873-6882

Author(s):

Huolun Feng ◽

Jiabin Zheng ◽

Chengbin Zheng ◽

Zhenru Deng ◽

Qianchao Liao ◽

...

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Esophagogastric Junction ◽

Population Based ◽

Type Ii ◽

Population Based Study ◽

Siewert Type ◽

Siewert Type Ii ◽

Node Metastasis ◽

Adenocarcinoma Of Esophagogastric Junction

Download Full-text

Assessment of risk factors of lymph node metastasis and prognosis of Siewert II/III adenocarcinoma of esophagogastric junction: a retrospective study

10.21203/rs.2.23871/v1 ◽

2020 ◽

Author(s):

Zhi Zheng ◽

Haiqiao Zhang ◽

Rui Xu ◽

Jie Yin ◽

Jun Cai ◽

...

Keyword(s):

Risk Factors ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Lymph Nodes ◽

Esophagogastric Junction ◽

Cox Regression ◽

Abdominal Cavity ◽

Infiltration Depth ◽

Node Metastasis ◽

Adenocarcinoma Of Esophagogastric Junction

Abstract Background Adenocarcinoma of esophagogastric junction (AEG) has a high incidence, while the extent of lymph node dissection (LND) and prognosis are still controversial. The present study aimed to explore the risk factors of lymph node metastasis (LNM) and prognosis in Siewert II/III AEG patients. Methods A total of 134 patients who underwent surgical operation between July 2013 and December 2019 at the Beijing Friendship Hospital were retrospectively reviewed. The patients were followed up until January 2020. The data were analyzed using logistic regression. Survival analyses were performed using Cox regression. Results Multivariate analysis revealed that the parameters infiltration depth (OR=4.341, 95%CI: 2.498-7.545, P=0.000), gross type (OR=3.626, 95% CI: 1.425-9.228, P=0.007) and intravascular cancer embolus (OR=2.888, 95%CI: 1.106-7.544, P=0.030) correlated with LNM. For all patients, the lymph nodes No. 1, 2, 3, 4, 7, 11 indicated higher lymph node metastatic rate in the abdominal cavity. However, No.5 and No. 6 indicated different tendency, which was higher in Siewert III AEG and lower in Siewert II AEG patients. Mediastinal LNM of Siewert II AEG mainly occurred in No. 110 and No. 111 cases corresponding to 7.1 and 3%, respectively, compared with those noted in Siewert III AEG patients. The 3-year overall survival analysis revealed that LNM ( P= 0.046) and chemotherapy ( P= 0.007) exhibited significant differences. Conclusion The infiltration depth, gross type and intravascular cancer embolus were independent risk factors of LNM. For Siewert II AEG patients, it is reasonable to remove both celiac and mediastinal lymph nodes. This was noted notably for No.1, 2, 3, 4, 7, 11, 110 and No.111. For No.5 and No.6 lymph nodes dissection was not required. For Siewert III AEG patients, mediastinal LND was not required. However, it was necessary to perform pyloric lymphadenectomy, which was performed for No.5 and No.6 lymph nodes. In addition, patients with LNM exhibited worse long-term prognosis. The data indicated that perioperative chemotherapy could improve the prognosis of AEG patients.

Download Full-text

Mediastinal lymph node metastasis and recurrence in adenocarcinoma of the esophagogastric junction

Surgery ◽

10.1016/j.surg.2014.08.099 ◽

2015 ◽

Vol 157 (3) ◽

pp. 551-555 ◽

Cited By ~ 45

Author(s):

Yukinori Kurokawa ◽

Naoki Hiki ◽

Takaki Yoshikawa ◽

Kentaro Kishi ◽

Yuichi Ito ◽

...

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Esophagogastric Junction ◽

Mediastinal Lymph Node ◽

Mediastinal Lymph Node Metastasis ◽

Node Metastasis

Download Full-text

The prognostic relevance of parapyloric lymph node metastasis in Siewert type II/III adenocarcinoma of the esophagogastric junction

Annals of Oncology ◽

10.1093/annonc/mdx261.123 ◽

2017 ◽

Vol 28 ◽

pp. iii48-iii49

Author(s):

Changming Huang ◽

Jia-Bin Wang ◽

Chao-Hui Zheng ◽

Ping Li ◽

Jian-Wei Xie

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Esophagogastric Junction ◽

Type Ii ◽

Siewert Type ◽

Siewert Type Ii ◽

Node Metastasis ◽

Prognostic Relevance

Download Full-text

Studies of the efficacy of postoperative radiation therapy for patients with cervical lymph node metastasis from oral squamous cell carcinoma

Japanese Journal of Oral & Maxillofacial Surgery ◽

10.5794/jjoms.55.125 ◽

2009 ◽

Vol 55 (3) ◽

pp. 125-131

Author(s):

Miho SUZUKI ◽

Yasuyuki MICHI ◽

Katsuya AIKO ◽

Kazuto KUROHARA ◽

Masashi YAMANE ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Radiation Therapy ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Oral Squamous Cell Carcinoma ◽

Cervical Lymph Node ◽

Cervical Lymph Node Metastasis ◽

Postoperative Radiation ◽

Postoperative Radiation Therapy ◽

Node Metastasis

Download Full-text

Radiation therapy for localised prostatic cancer: Our experience with combined radiotherapy and androgen deprivation

Urologia Journal ◽

10.1177/039156039606301s07 ◽

1996 ◽

Vol 63 (1_suppl) ◽

pp. 32-34

Author(s):

S. Guazzieri ◽

R. Bertoldin ◽

G. D'INCà ◽

G. De Marchi ◽

S. Guatelli ◽

...

Keyword(s):

Radiation Therapy ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Median Time ◽

Prostatic Cancer ◽

Regional Lymph Node ◽

Combined Treatment ◽

Androgen Deprivation ◽

Node Metastasis

Sixty-nine patients with localised prostatic cancer, who could not undergo radical prostatectomy due to loco-regional lymph node metastasis or anaesthesiological counter-indications, were subjected to a combined treatment, radiation therapy and androgen deprivation. All patients underwent pelvio-lymphadenectomy and those with cervico-urethral obstruction, endoscopic resection of the prostate. There was a progression of the disease in 33% of patients with lymph node metastasis (median time of progression 33 months) and in 27% of those without (median time of progression 22 months). Stable disease in 67% of patients (median follow-up over 3 years).

Download Full-text

VS01.06: THORACOSCOPIC EXTENDED LYMPHADENECTOMY FOR EGJ CANCER: AN OPTION TO LEARN FROM THE EAST

Diseases of the Esophagus ◽

10.1093/dote/doy089.vs01.06 ◽

2018 ◽

Vol 31 (Supplement_1) ◽

pp. 45-45

Author(s):

Simone Giacopuzzi ◽

Jacopo Weindelmayer ◽

Giovanni De Manzoni

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Recurrent Laryngeal Nerve ◽

Esophagogastric Junction ◽

Conflicts Of Interest ◽

Laryngeal Nerve ◽

Extended Lymphadenectomy ◽

Node Dissection ◽

Node Metastasis ◽

The Right

Abstract Description Extended thoracoscopic lymphadenectomy is not common practice in Western countries in patients with adenocarcinoma of the esophagogastric junction. In this video we present a case of a patient with siewert I adenocarcinoma with lymph node metastasis to the right recurrent laryngeal nerve not treated with neoadjuvant therapy, due to comorbidity. The operation was: extended thoracoscopic en-block lymph node dissection. video will be edited in a more rigorous manner Disclosure All authors have declared no conflicts of interest.

Download Full-text