Intensity Modulated Radiation Therapy and Second Cancer Risk in Adults

2018 ◽  
Vol 100 (1) ◽  
pp. 17-20 ◽  
Author(s):  
Andrea Riccardo Filippi ◽  
Valentina Vanoni ◽  
Bruno Meduri ◽  
Luca Cozzi ◽  
Marta Scorsetti ◽  
...  
2014 ◽  
Vol 62 (2) ◽  
pp. 311-316 ◽  
Author(s):  
Dana L. Casey ◽  
Danielle N. Friedman ◽  
Chaya S. Moskowitz ◽  
Patrick D. Hilden ◽  
Charles A. Sklar ◽  
...  

2020 ◽  
pp. 20200354
Author(s):  
Claire Timlin ◽  
James Loken ◽  
Jon Kruse ◽  
Robert Miller ◽  
Uwe Schneider

Objectives: To assess if Excess Absolute Risk (EAR) of radiation-induced solid cancer can be used to rank radiotherapy plans for treatment of Hodgkin Lymphoma (HL) in a statistically significant way. Methods: EAR models, calibrated with data from the Life Span Study and HL survivors, have been incorporated into a voxelised risk-calculation software, which is used to compare four treatment modalities planned for five virtual HL patients. Organ-specific parameters are generated repeatedly in a Monte Carlo fashion to model their uncertainties. This in turn enables a quantitative estimation of the EAR uncertainties. Results: Parameter driven uncertainties on total EAR are around 13%, decreasing to around 2–5% for relative EAR comparisons. Total EAR estimations indicate that Intensity Modulated Proton Therapy decreases the average risk by 40% compared to the Intensity Modulated Radiation Therapy plan, 28% compared to the Volumetric Modulated Arc Therapy plan whereas the 3D Conformal Radiation Therapy plan is equivalent within the uncertainty. Conclusions: Relative EAR is a useful metric for distinguishing between radiotherapy plans in terms of second cancer risk. Advances in knowledge: Relative EAR is not dominated by model or parameter uncertainties and can be used to guide the choice of radiotherapy for HL patients.


2018 ◽  
Vol 182 (2) ◽  
pp. 208-214 ◽  
Author(s):  
Michalis Mazonakis ◽  
Stefanos Kachris ◽  
John Damilakis

2012 ◽  
Vol 84 (3) ◽  
pp. S420-S421
Author(s):  
M.R. Folkert ◽  
M.J. Zelefsky ◽  
A. Fidaleo ◽  
D.R. Feldman ◽  
G.J. Bosl ◽  
...  

2012 ◽  
Vol 103 (1) ◽  
pp. 12-17 ◽  
Author(s):  
Jason A. Efstathiou ◽  
Jonathan J. Paly ◽  
Hsiao-Ming Lu ◽  
Basit S. Athar ◽  
Maryam Moteabbed ◽  
...  

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