Pre-operative neutrophil lymphocyte ratio greater than 5 is a prognostic factor for recurrent colorectal cancer

Objective : To evaluate the significance of preoperative neutrophil-lymphocyte ratio (NLR) for the analysis of disease-free survival (DFS) and overall survival (OS) in patients with stage II colorectal cancer (CRC).Summary of Background Data: Previous reports have indicated the association of NLR with a poor prognosis and tumor progression in patients with CRC. However, the role of NLR as a prognostic marker specifically in patients with stage II CRC has not been well studied.Methods : A total of 124 colon cancer patients were included in the study. The OS and DFS of patients were compared using preoperative NLR. Univariate and multivariate analyses using the Cox proportional hazards model were performed to determine the prognostic value of NLR.Results : The OS and DFS of patients with an NLR ≥ 4.0 were significantly lower when compared with those of patients with an NLR< 4.0. Multivariate analysis showed that NLR ≥ 4.0, PS score ≥ 1, and depth of tumor invasion T4 were independent prognostic factors for DFS, whereas age above 80 years, NLR ≥ 4.0, and PS score ≥ 1 were independent prognostic factors for OS.Conclusions : NLR can be considered a poor prognostic factor in patients with stage II CRC after curative surgery.

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The prognostic and diagnostic significance of the neutrophil-to-lymphocyte ratio in hepatocellular carcinoma: a prospective controlled study

British Journal of Cancer ◽

10.1038/s41416-021-01445-3 ◽

2021 ◽

Author(s):

Philip J. Johnson ◽

Sofi Dhanaraj ◽

Sarah Berhane ◽

Laura Bonnett ◽

Yuk Ting Ma

Keyword(s):

Hepatocellular Carcinoma ◽

Regression Analysis ◽

Prognostic Factor ◽

Cox Regression ◽

Prognostic Models ◽

Controlled Study ◽

Cox Regression Analysis ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Significant Difference

Abstract Background The neutrophil–lymphocyte ratio (NLR), a presumed measure of the balance between neutrophil-associated pro-tumour inflammation and lymphocyte-dependent antitumour immune function, has been suggested as a prognostic factor for several cancers, including hepatocellular carcinoma (HCC). Methods In this study, a prospectively accrued cohort of 781 patients (493 HCC and 288 chronic liver disease (CLD) without HCC) were followed-up for more than 6 years. NLR levels between HCC and CLD patients were compared, and the effect of baseline NLR on overall survival amongst HCC patients was assessed via multivariable Cox regression analysis. Results On entry into the study (‘baseline’), there was no clinically significant difference in the NLR values between CLD and HCC patients. Amongst HCC patients, NLR levels closest to last visit/death were significantly higher compared to baseline. Multivariable Cox regression analysis showed that NLR was an independent prognostic factor, even after adjustment for the HCC stage. Conclusion NLR is a significant independent factor influencing survival in HCC patients, hence offering an additional dimension in prognostic models.

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