Characterization of B7H6, an endogenous ligand for the NK cell activating receptor NKp30, reveals the identity of two different soluble isoforms during normal human pregnancy

Immunobiology ◽  
2018 ◽  
Vol 223 (1) ◽  
pp. 57-63 ◽  
Author(s):  
Jorge Gutierrez-Franco ◽  
Rodolfo Hernandez-Gutierrez ◽  
Miriam Ruth Bueno-Topete ◽  
Jesse Haramati ◽  
Rosa Elena Navarro-Hernandez ◽  
...  
Keyword(s):  
Nk Cell ◽  
Endogenous Ligand ◽  
Human Pregnancy ◽  
Normal Human ◽  
Activating Receptor

NK Cell Activity and Estrogen Hormone Levels during Normal Human Pregnancy

1988 ◽  
Vol 25 (3) ◽  
pp. 165-172 ◽  
Author(s):  
Jelka Gabrilovac ◽  
Josip Zadjelović ◽  
Maja Osmak ◽  
Ernest Suchanek ◽  
Željko Županović ◽  
...  
Keyword(s):  
Nk Cell ◽  
Cell Activity ◽  
Nk Cell Activity ◽  
Hormone Levels ◽  
Human Pregnancy ◽  
Normal Human

scholarly journals 328 Chorionic villi angiogenic protein expression in normal human pregnancy

2021 ◽  
Vol 224 (2) ◽  
pp. S215-S216
Author(s):  
Jayasri Basu ◽  
Yingyi Wu ◽  
Sara Oraee ◽  
Diana Encalada ◽  
Aruna Mishra ◽  
...  
Keyword(s):  
Protein Expression ◽  
Chorionic Villi ◽  
Human Pregnancy ◽  
Normal Human

Characterization of the human natural killer (NK) cell in blood and lymphoid organs

1978 ◽  
Vol 21 (1) ◽  
pp. 42-50 ◽  
Author(s):  
O. Eremin ◽  
R. R. A. Coombs ◽  
D. Plumb ◽  
J. Ashby
Keyword(s):  
Natural Killer ◽  
Nk Cell ◽  
Lymphoid Organs

Serum heat shock protein 70 levels are decreased in normal human pregnancy

2007 ◽  
Vol 74 (1-2) ◽  
pp. 163-169 ◽  
Author(s):  
Attila Molvarec ◽  
János Rigó ◽  
Bálint Nagy ◽  
Szilvia Walentin ◽  
János Szalay ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Human Pregnancy ◽  
Normal Human

scholarly journals Maternal uterine NK cell–activating receptor KIR2DS1 enhances placentation

2013 ◽  
Vol 123 (10) ◽  
pp. 4264-4272 ◽  
Author(s):  
Shiqiu Xiong ◽  
Andrew M. Sharkey ◽  
Philippa R. Kennedy ◽  
Lucy Gardner ◽  
Lydia E. Farrell ◽  
...  
Keyword(s):  
Nk Cell ◽  
Activating Receptor

Purification and characterization of the yeast-expressed erythropoietin mutant Epo (R103A), a specific inhibitor of human primary hematopoietic cell erythropoiesis

Blood ◽  
2002 ◽  
Vol 99 (12) ◽  
pp. 4400-4405 ◽  
Author(s):  
Suzanne Burns ◽  
Murat O. Arcasoy ◽  
Li Li ◽  
Elizabeth Kurian ◽  
Katri Selander ◽  
...  
Keyword(s):  
Animal Models ◽  
Specific Inhibitor ◽  
Competitive Inhibitor ◽  
Erythropoietin Receptor ◽  
Single Amino Acid ◽  
Human Cd34 ◽  
Unit Formation ◽  
Dependent Cell ◽  
Normal Human

A drug that specifically inhibits erythropoiesis would be clinically useful. The erythropoietin (Epo) mutant Epo (R103A) could potentially be used for this purpose. Epo (R103A) has a single amino acid substitution of alanine for arginine at position 103. Because of this mutation, Epo (R103A) is only able to bind to one of the 2 subunits of the erythropoietin receptor (EpoR) homodimer and is thus a competitive inhibitor of Epo activity. To produce large quantities of Epo (R103A) to test in animal models of thalassemia and sickle cell disease, we expressed and purified recombinant Epo (R103A) from the yeast Pichia pastoris. Using this method milligram quantities of highly purified Epo (R103A) are obtained. The yeast-expressed Epo (R103A) is properly processed and glycosylated and specifically inhibits Epo-dependent cell growth and125I-Epo binding. Epo (R103A) does not, however, directly induce apoptosis in 32D cells expressing EpoR. Epo (R103A) inhibits erythropoiesis of human CD34+ hematopoietic cells and completely blocks erythroid burst-forming unit formation in normal human bone marrow colony assays. Yeast-expressed Epo (R103A) is a specific inhibitor of primary erythropoiesis suitable for testing in animal models.

Architectural and Immunohistochemical Characterization of Biliary Ductules in Normal Human Liver

2009 ◽  
Vol 18 (10) ◽  
pp. 1417-1422 ◽  
Author(s):  
Katalin Dezső ◽  
Sándor Paku ◽  
Veronika Papp ◽  
Eszter Turányi ◽  
Peter Nagy
Keyword(s):  
Human Liver ◽  
Normal Human Liver ◽  
Normal Human
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