Subacute silica nanoparticle exposure induced oxidative stress and inflammation in rat hippocampus combined with disruption of cholinergic system and behavioral functions

NanoImpact ◽  
2021 ◽  
pp. 100358
Author(s):  
Khadija Boukholda ◽  
Brahim Gargouri ◽  
Bakhta Aouey ◽  
Abdelraheim Attaai ◽  
Mohamed Abd Elkodous ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cholinergic System ◽  
Silica Nanoparticle ◽  
Rat Hippocampus ◽  
Nanoparticle Exposure

scholarly journals Bay Leaf (Laurus Nobilis L.) Incense Improved Scopolamine-Induced Amnesic Rats by Restoring Cholinergic Dysfunction and Brain Antioxidant Status

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 259
Author(s):  
Ion Brinza ◽  
Razvan Stefan Boiangiu ◽  
Monica Hancianu ◽  
Oana Cioanca ◽  
Ilkay Erdogan Orhan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cholinergic System ◽  
Antioxidant Activities ◽  
Biological Activities ◽  
Rat Hippocampus ◽  
Antimutagenic Activity ◽  
Laurus Nobilis ◽  
Stress Markers ◽  
Y Maze ◽  
Gas Chromatograph Mass Spectrometry

Bay leaf (Laurus nobilis L.) has been shown to possesses various biological activities such as wound healing activity, antioxidant activity, antibacterial activity, antiviral activity, immunostimulant activity, anticholinergic activity, antifungal activity, insect repellant activity, anticonvulsant activity, antimutagenic activity, and analgesic and anti-inflammatory activity. The present study aimed to investigate whether the bay leaf incense (BL) elicits the memory formation via the action on the cholinergic system using a scopolamine (Sco)-induced rat model. Rats were exposed to BL over 5 min in a smoking chamber apparatus once daily for 22 days, whereas memory impairment was induced by Sco (0.7 mg/kg), a muscarinic receptor antagonist, delivered 30 min before each behavioral test. The phytochemical composition of BL was achieved by gas chromatograph–mass spectrometry (GCMS). Behavioral effects in rats were assessed by Y-maze, radial arm maze (RAM), and novel object recognition (NOR) paradigms. Additionally, the acetylcholinesterase (AChE) activity and the oxidative stress markers in the rat hippocampus were also evaluated. Exposure to BL significantly ameliorated Sco-induced cognitive impairment and oxidative stress in the rat hippocampus. The obtained results suggested that BL-induced ameliorative cognitive effects are mediated by enhancement of the cholinergic system and antioxidant activities.

Oxidative stress in rat hippocampus caused by pilocarpine-induced seizures is reversed by buspirone

2010 ◽  
Vol 81 (4-5) ◽  
pp. 505-509 ◽  
Author(s):  
Rizângela Lyne Mendes de Freitas ◽  
Ítala Mônica de Sales Santos ◽  
Geane Felix de Souza ◽  
Adriana da Rocha Tomé ◽  
Gláucio Barros Saldanha ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Hippocampus

Age-related changes in apoptosis in rat hippocampus induced by oxidative stress

2011 ◽  
Vol 87 (2) ◽  
pp. 98-104 ◽  
Author(s):  
N Uysal ◽  
K Tugyan ◽  
I Aksu ◽  
S Ozbal ◽  
D Ozdemir ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Hippocampus ◽  
Age Related ◽  
Age Related Changes

Mauritia flexuosa L. protects against deficits in memory acquisition and oxidative stress in rat hippocampus induced by methylmercury exposure

2016 ◽  
Vol 20 (5) ◽  
pp. 297-304 ◽  
Author(s):  
Luana K. R. Leão ◽  
Anderson M. Herculano ◽  
Caio Maximino ◽  
Alódia Brasil Costa ◽  
Amauri Gouveia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Hippocampus ◽  
Mauritia Flexuosa ◽  
Methylmercury Exposure ◽  
Memory Acquisition ◽  
And Oxidative Stress

scholarly journals Silica nanoparticle exposure during the neonatal period impairs hippocampal precursor proliferation and social behavior later in life

2018 ◽  
Vol Volume 13 ◽  
pp. 3593-3608 ◽  
Author(s):  
Jingjing Fu ◽  
Junwei Gao ◽  
Linji Gong ◽  
Yuanyuan Ma ◽  
Haiwei Xu ◽  
...  
Keyword(s):  
Social Behavior ◽  
Neonatal Period ◽  
Silica Nanoparticle ◽  
Nanoparticle Exposure
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