scholarly journals Zika viral proteome analysis reveals an epitope cluster within NS3 helicase as a potential vaccine candidate: An in silico study

2020 ◽  
Vol 21 ◽  
pp. 100434
Author(s):  
Md Tangigul Haque ◽  
Md Nur Ahad Shah ◽  
Shatabdi Paul ◽  
Md Kawsar Khan ◽  
Payal Barua
Keyword(s):  
In Silico ◽  
Vaccine Candidate ◽  
Proteome Analysis ◽  
Potential Vaccine Candidate ◽  
In Silico Study ◽  
Potential Vaccine

Improvement of the attenuated mutant strain of Brucella melitensis Rev1 as a potential vaccine candidate

Biologia ◽  
2021 ◽  
Author(s):  
Elham Mehdizadeh Marzenaki ◽  
Ali Reza Saeedinia ◽  
Mehdi Zeinoddini ◽  
Ali Asghar Deldar
Keyword(s):  
Mutant Strain ◽  
Vaccine Candidate ◽  
Brucella Melitensis ◽  
Potential Vaccine Candidate ◽  
Potential Vaccine

scholarly journals Moraxella catarrhalis Bacterium without Endotoxin, a Potential Vaccine Candidate

2005 ◽  
Vol 73 (11) ◽  
pp. 7569-7577 ◽  
Author(s):  
Daxin Peng ◽  
Wenzhou Hong ◽  
Biswa P. Choudhury ◽  
Russell W. Carlson ◽  
Xin-Xing Gu
Keyword(s):  
Moraxella Catarrhalis ◽  
Lipid A ◽  
Vaccine Candidate ◽  
Gene Encoding ◽  
Potential Vaccine Candidate ◽  
Whole Cells ◽  
Potential Vaccine ◽  
Major Surface ◽  
Membrane Components ◽  
Human Infections

ABSTRACT Lipooligosaccharide (LOS) is a major surface component of Moraxella catarrhalis and a possible virulence factor in the pathogenesis of human infections caused by this organism. The presence of LOS on the bacterium is an obstacle to the development of vaccines derived from whole cells or outer membrane components of the bacterium. An lpxA gene encoding UDP-N-acetylglucosamine acyltransferase responsible for the first step of lipid A biosynthesis was identified by the construction and characterization of an isogenic M. catarrhalis lpxA mutant in strain O35E. The resulting mutant was viable despite the complete loss of LOS. The mutant strain showed significantly decreased toxicity by the Limulus amebocyte lysate assay, reduced resistance to normal human serum, reduced adherence to human epithelial cells, and enhanced clearance in lungs and nasopharynx in a mouse aerosol challenge model. Importantly, the mutant elicited high levels of antibodies with bactericidal activity and provided protection against a challenge with the wild-type strain. These data suggest that the null LOS mutant is attenuated and may be a potential vaccine candidate against M. catarrhalis.

scholarly journals Large Extracellular Loop of Tetraspanin as a Potential Vaccine Candidate for Filariasis

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e77394 ◽  
Author(s):  
Gajalakshmi Dakshinamoorthy ◽  
Gnanasekar Munirathinam ◽  
Kristen Stoicescu ◽  
Maryada Venkatarami Reddy ◽  
Ramaswamy Kalyanasundaram
Keyword(s):  
Vaccine Candidate ◽  
Extracellular Loop ◽  
Potential Vaccine Candidate ◽  
Large Extracellular Loop ◽  
Potential Vaccine

scholarly journals Reverse vaccinology approach to design a novel multi-epitope vaccine candidate against COVID-19: an in silico study

2020 ◽  
pp. 1-16 ◽  
Author(s):  
Maryam Enayatkhani ◽  
Mehdi Hasaniazad ◽  
Sobhan Faezi ◽  
Hamed Gouklani ◽  
Parivash Davoodian ◽  
...  
Keyword(s):  
In Silico ◽  
Vaccine Candidate ◽  
Reverse Vaccinology ◽  
Epitope Vaccine ◽  
In Silico Study
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