Novel 2-(2,5-methoxy-phenyl) imidazo [4,5-f]-[1, 10] phenanthrolin platinum(II) complex display high anticancer activity via dysfunction of mitochondrial signaling pathway

2019 ◽  
Vol 101 ◽  
pp. 99-102
Author(s):  
Yi-Dong Bin ◽  
Yan Yang ◽  
Xu-Jian Luo ◽  
Hua-Xin Zhang
Keyword(s):  
Anticancer Activity ◽  
Signaling Pathway ◽  
Mitochondrial Signaling ◽  
Complex Display

Microcystin-LR induces angiodysplasia and vascular dysfunction through promoting cell apoptosis by the mitochondrial signaling pathway

Chemosphere ◽  
2019 ◽  
Vol 218 ◽  
pp. 438-448 ◽  
Author(s):  
Qilong Wang ◽  
Yuanli Liu ◽  
Jingsong Guo ◽  
Song Lin ◽  
Yeqi Wang ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Cell Apoptosis ◽  
Vascular Dysfunction ◽  
Mitochondrial Signaling

scholarly journals Deletion of Bmal1 Impairs Pancreatic β-Cell Function via Mitochondrial Signaling Pathway

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Lu Ye ◽  
Huaxiang Wu ◽  
Weihong Xu
Keyword(s):  
Signaling Pathway ◽  
Cell Function ◽  
Mitofusin 2 ◽  
Insulinoma Cell ◽  
Mitochondrial Signaling ◽  
Β Cell Function ◽  
Mrna And Protein Expression ◽  
Glucose Stimulated Insulin Secretion ◽  
Mitofusin 1 ◽  
Interfering Rna

Several studies have demonstrated that brain and muscle Arnt-like protein-1 (Bmal1) acts as a core clock gene for maintaining normal cell function, including hepatocytes and cardiomyocytes. Loss of Bmal1 is associated with type 2 diabetes due to pancreatic β-cell failure. However, little information is available about its role and mechanism in pancreatic β-cell. To address this, we investigated the consequences of Bmal1 inhibition in an insulinoma cell line (INS-1) by using small interfering RNA (siRNA). We observed that knockout of Bmal1 impaired glucose-stimulated insulin secretion in β-cell. Meanwhile, the depletion of Bmal1 in β-cell caused an adverse change in mitochondrial membrane potential and mitochondrial architecture. Deletion of Bmal1 attenuated mRNA and protein expression of mitofusin 1 (Mfn1) and mitofusin 2 (Mfn2) and enhanced the expression of fission 1 (Fis1). In summary, the deletion of Bmal1 impaired β-cell function may be via the mitochondrial signaling pathway in INS-1 cells.

3-O-(E)-p-Coumaroyl betulinic acid possess anticancer activity and inhibit Notch signaling pathway in breast cancer cells and mammosphere

2020 ◽  
Vol 328 ◽  
pp. 109200
Author(s):  
Prem Prakash Kushwaha ◽  
Atul Kumar Singh ◽  
Mohd Shuaib ◽  
Kumari Sunita Prajapati ◽  
Pothabathula Seshu Vardhan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Notch Signaling ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Betulinic Acid ◽  
Breast Cancer Cells ◽  
Notch Signaling Pathway

scholarly journals PACE4 regulates apoptosis in human pancreatic cancer Panc-1 cells via the mitochondrial signaling pathway

2016 ◽  
Vol 14 (6) ◽  
pp. 5205-5210
Author(s):  
Xiao-Feng Tian ◽  
Guo-Min Huang ◽  
Hong-Liang Zang ◽  
Hong Cao
Keyword(s):  
Pancreatic Cancer ◽  
Signaling Pathway ◽  
Human Pancreatic Cancer ◽  
Mitochondrial Signaling

scholarly journals Apoptosis is induced by shikonin through the mitochondrial signaling pathway

2016 ◽  
Vol 13 (4) ◽  
pp. 3668-3674 ◽  
Author(s):  
XUXIA TANG ◽  
CHEN ZHANG ◽  
JIONGZHOU WEI ◽  
YUTING FANG ◽  
RONGXIANG ZHAO ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Mitochondrial Signaling
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