HSP60 regulates the cigarette smoke-induced activation of TLR4-NF-κB-MyD88 signalling pathway and NLRP3 inflammasome

2022 ◽  
Vol 103 ◽  
pp. 108445
Author(s):  
Guochun Ou ◽  
Mingmei Zhu ◽  
Yufang Huang ◽  
Wen Luo ◽  
Jie Zhao ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Nlrp3 Inflammasome ◽  
Signalling Pathway

HSP60 Regulates the Cigarette Smoke-Induced Activation of TLR4-NF-κB-MyD88 Signaling Pathway and NLRP3 Inflammasome

2021 ◽  
Author(s):  
Guochun Ou ◽  
Mingmei Zhu ◽  
Yufang Huang ◽  
Wen Luo ◽  
Jie Zhao ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Cigarette Smoke ◽  
Nlrp3 Inflammasome ◽  
Myd88 Signaling

scholarly journals AVE 0991 Attenuates Pyroptosis and Liver Damage after Heatstroke by Inhibiting the ROS-NLRP3 Inflammatory Signalling Pathway

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Ming Zhang ◽  
Xintao Zhu ◽  
Huasheng Tong ◽  
Anni Lou ◽  
Yue Li ◽  
...  
Keyword(s):  
Heat Stress ◽  
Liver Damage ◽  
Nlrp3 Inflammasome ◽  
Hepatic Dysfunction ◽  
Signalling Pathway ◽  
Ang Ii ◽  
Caspase 1 ◽  
Angiotensin Peptides ◽  
Potential Biomarker ◽  
Inflammatory Signalling

We previously demonstrated that angiotensin-(1-7) (Ang-(1-7)), an essential endocrine factor, inhibits the NLRP3 inflammasome by regulating reactive oxygen species (ROS) in fibrotic livers. We also demonstrated that the NLRP3 inflammasome contributes to the liver damage induced by pyroptosis after heatstroke. However, the role of Ang-(1-7) in the hepatocytes under heat stress remains uncertain. We aimed to examine the change in angiotensin peptides in the livers affected by heatstroke and the effect on the ROS-NLRP3 inflammatory signalling pathway. In vivo, increased angiotensin II (Ang II) and decreased Ang-(1-7) in the serum of heatstroke patients suffering from hepatic dysfunction were observed. The change in angiotensin peptides was considered a potential biomarker that could be used to predict hepatic dysfunction. Enhanced Ang II and attenuated Ang-(1-7) levels were also observed in the liver tissue of heatstroke rats, which were consistent with their receptors and converting enzymes. Hepatic damage associated with increased ROS and protein expression levels of NOX4, NLRP3, caspase-1, and IL-1β was attenuated by AVE 0991, an analogue of Ang-(1-7). In vitro, pyroptosis, characterized by activated caspase-1 and IL-1β, was observed in hepatocytes under heat stress, which was enhanced by Ang II and attenuated by antioxidants, NOX4 siRNA, and AVE 0991. In summary, AVE 0991 attenuates pyroptosis and liver damage induced by heat stress by inhibiting the ROS-NLRP3 inflammatory signalling pathway.

scholarly journals Huoxue Qianyang Qutan recipe attenuates cardiac fibrosis by inhibiting the NLRP3 inflammasome signalling pathway in obese hypertensive rats

2021 ◽  
Vol 59 (1) ◽  
pp. 1045-1057
Author(s):  
Bo Lu ◽  
Jun Xie ◽  
Deyu Fu ◽  
Xiaozhe Chen ◽  
Mingyi Zhao ◽  
...  
Keyword(s):  
Nlrp3 Inflammasome ◽  
Cardiac Fibrosis ◽  
Signalling Pathway ◽  
Hypertensive Rats
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