28.4 A PRELIMINARY STUDY OF THE MINDFULNESS BASED COGNITIVE THERAPY ON BRAIN NETWORKS OF YOUTH WITH MOOD DYSREGULATION

AbstractVery little is known about the role of effective cognitive therapy in reversing imbalances in brain activity after trauma. We hypothesised that exaggerated threat perception characteristic of post-traumatic stress disorder (PTSD), and subsequent recovery from this disorder, are underpinned by changes in the dynamics of large-scale brain networks. Here, we use a novel data-driven approach with high temporal precision to find recurring brain networks from fMRI data and estimate when these networks become active during exposure to either trauma reminders or neutral pictures. We found that PTSD patients spend less time in two default mode sub-networks in contrast to trauma-exposed healthy controls, and that PTSD symptom severity correlates positively with time spent in the salience network during exposure to trauma reminders. The former are important for different aspects of self-referential processing and the latter for detection of threat. Importantly, the decreased time in the default mode sub-networks is rebalanced after successful cognitive therapy for PTSD. Our results show that remittance of PTSD through trauma-focused cognitive therapy is associated with the successful reinstatement of a healthy balance in self-referential and threat detection brain networks.

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Mindfulness-based cognitive therapy as a treatment for chronic depression: A preliminary study

Behaviour Research and Therapy ◽

10.1016/j.brat.2009.01.019 ◽

2009 ◽

Vol 47 (5) ◽

pp. 366-373 ◽

Cited By ~ 204

Author(s):

Thorsten Barnhofer ◽

Catherine Crane ◽

Emily Hargus ◽

Myanthi Amarasinghe ◽

Rosie Winder ◽

...

Keyword(s):

Cognitive Therapy ◽

Chronic Depression ◽

Preliminary Study

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Mindfulness-based cognitive therapy may reduce thought suppression in previously suicidal participants: Findings from a preliminary study

British Journal of Clinical Psychology ◽

10.1348/014466509x414970 ◽

2009 ◽

Vol 48 (2) ◽

pp. 209-215 ◽

Cited By ~ 31

Author(s):

Silvia R. Hepburn ◽

Catherine Crane ◽

Thorsten Barnhofer ◽

Danielle S. Duggan ◽

Melanie J. V. Fennell ◽

...

Keyword(s):

Cognitive Therapy ◽

Thought Suppression ◽

Preliminary Study

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Emotional Disorders and Metacognition: Innovative Cognitive Therapy. By A. Wells. (Pp. 236; £34.95.) John Wiley & Sons: Chichester. 2001.

Psychological Medicine ◽

10.1017/s0033291702225702 ◽

2002 ◽

Vol 32 (04) ◽

Author(s):

LEYLAND C. SHEPPARD

Keyword(s):

Cognitive Therapy ◽

Emotional Disorders

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The Ultrastructure of Metastatic Human Mammary Carcinoma After Prolonged Estrogen Therapy

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010006091x ◽

1967 ◽

Vol 25 ◽

pp. 180-181

Author(s):

John H.L. Watson ◽

John L. Swedo ◽

R.W. Talley

Keyword(s):

Mammary Carcinoma ◽

Osmium Tetroxide ◽

Estrogen Therapy ◽

Ultrastructural Level ◽

Uranyl Acetate ◽

Human Mammary Carcinoma ◽

Surgical Biopsy ◽

Lead Hydroxide ◽

Preliminary Study ◽

Hormonal Therapies

A preliminary study of human mammary carcinoma on the ultrastructural level is reported for a metastatic, subcutaneous nodule, obtained as a surgical biopsy. The patient's tumor had responded favorably to a series of hormonal therapies, including androgens, estrogens, progestins, and corticoids for recurring nodules over eight years. The pertinent nodule was removed from the region of the gluteal maximus, two weeks following stilbestrol therapy. It was about 1.5 cms in diameter, and was located within the dermis. Pieces from it were fixed immediately in cold fixatives: phosphate buffered osmium tetroxide, glutaraldehyde, and paraformaldehyde. Embedment in each case was in Vestopal W. Contrasting was done with combinations of uranyl acetate and lead hydroxide.

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Fine structure of early degenerating myofibers in the tibialis anterior of young ‘MDX’ mouse

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010010367x ◽

1988 ◽

Vol 46 ◽

pp. 322-323

Author(s):

H.D. Geissinger ◽

C.K. McDonald-Taylor

Keyword(s):

Fine Structure ◽

Muscle Regeneration ◽

Tibialis Anterior ◽

Genetic Defect ◽

Mdx Mouse ◽

Mdx Mice ◽

Histopathological Changes ◽

Electron Microscopic ◽

Dystrophic Mouse ◽

Preliminary Study

A new strain of mice, which had arisen by mutation from a dystrophic mouse colony was designated ‘mdx’, because the genetic defect, which manifests itself in brief periods of muscle destruction followed by episodes of muscle regeneration appears to be X-linked. Further studies of histopathological changes in muscle from ‘mdx’ mice at the light microscopic or electron microscopic levels have been published, but only one preliminary study has been on the tibialis anterior (TA) of ‘mdx’ mice less than four weeks old. Lesions in the ‘mdx’ mice vary between different muscles, and centronucleation of fibers in all muscles studied so far appears to be especially prominent in older mice. Lesions in young ‘mdx’ mice have not been studied extensively, and the results appear to be at variance with one another. The degenerative and regenerative aspects of the lesions in the TA of 23 to 26-day-old ‘mdx’ mice appear to vary quantitatively.

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Ultrastructural observations of the aorta of calves implanted with a mechanical left ventricular assist device

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100161734 ◽

1990 ◽

Vol 48 (3) ◽

pp. 834-835

Author(s):

J P Cassella ◽

V Salih ◽

T R Graham

Keyword(s):

Left Ventricular Assist Device ◽

Ventricular Assist Device ◽

Left Ventricular ◽

Aortic Tissue ◽

Assist Device ◽

Ventricular Assist ◽

Transmission Electron ◽

Left Ventricular Assist ◽

Preliminary Study

Left ventricular assist systems are being developed for eventual long term or permanent implantation as an alternative to heart transplantation in patients unsuitable for or denied the transplant option. Evaluation of the effects of these devices upon normal physiology is required. A preliminary study was conducted to evaluate the morphology of aortic tissue from calves implanted with a pneumatic Left Ventricular Assist device-LVAD. Two 3 month old heifer calves (calf 1 and calf 2) were electively explanted after 128 days and 47 days respectively. Descending thoracic aortic tissue from both animals was removed immediately post mortem and placed into karnovsky’s fixative. The tissue was subsequently processed for transmission electron microscopy (TEM). Some aortic tissue was fixed in neutral buffered formalin and processed for routine light microscopy.

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